scholarly journals Introductory Chapter: Invitation for Peripheral Membrane Proteins

2018 ◽  
Author(s):  
Shihori Tanabe
Keyword(s):  
Membrane Proteins ◽  
Peripheral Membrane Proteins

scholarly journals Basic Residue Clusters in Intrinsically Disordered Regions of Peripheral Membrane Proteins: Modulating 2D Diffusion on Cell Membranes

Physchem ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 152-162
Author(s):  
Miquel Pons
Keyword(s):  
Membrane Proteins ◽  
Electrostatic Interactions ◽  
Lipid Membrane ◽  
Conformational Ensemble ◽  
Basic Residue ◽  
Intrinsically Disordered ◽  
Intrinsically Disordered Regions ◽  
Peripheral Membrane Proteins ◽  
Charged Residues ◽  
Disordered Regions

A large number of peripheral membrane proteins transiently interact with lipids through a combination of weak interactions. Among them, electrostatic interactions of clusters of positively charged amino acid residues with negatively charged lipids play an important role. Clusters of charged residues are often found in intrinsically disordered protein regions, which are highly abundant in the vicinity of the membrane forming what has been called the disordered boundary of the cell. Beyond contributing to the stability of the lipid-bound state, the pattern of charged residues may encode specific interactions or properties that form the basis of cell signaling. The element of this code may include, among others, the recognition, clustering, and selective release of phosphatidyl inositides, lipid-mediated protein-protein interactions changing the residence time of the peripheral membrane proteins or driving their approximation to integral membrane proteins. Boundary effects include reduction of dimensionality, protein reorientation, biassing of the conformational ensemble of disordered regions or enhanced 2D diffusion in the peri-membrane region enabled by the fuzzy character of the electrostatic interactions with an extended lipid membrane.

Peripheral Membrane Proteins

1996 ◽  
pp. 355-403 ◽  
Author(s):  
Barbara A. Seaton ◽  
Mary F. Roberts
Keyword(s):  
Membrane Proteins ◽  
Peripheral Membrane Proteins

scholarly journals Contrast-Matched Isotropic Bicelles: A Versatile Tool to Specifically Probe the Solution Structure of Peripheral Membrane Proteins Using SANS

Langmuir ◽  
2017 ◽  
Vol 33 (26) ◽  
pp. 6572-6580 ◽  
Author(s):  
Raphael Dos Santos Morais ◽  
Olivier Delalande ◽  
Javier Pérez ◽  
Liza Mouret ◽  
Arnaud Bondon ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Solution Structure ◽  
Peripheral Membrane Proteins ◽  
Versatile Tool

scholarly journals A Proline-rich Region and Nearby Cysteine Residues Target XLαs to the Golgi Complex Region

2000 ◽  
Vol 11 (4) ◽  
pp. 1421-1432 ◽  
Author(s):  
Ozlem Ugur ◽  
Teresa L. Z. Jones
Keyword(s):  
Membrane Proteins ◽  
G Protein ◽  
Splice Variant ◽  
Fluorescent Protein ◽  
Cysteine Residues ◽  
Rich Region ◽  
Peripheral Membrane Proteins ◽  
Golgi Membranes ◽  
Membrane Attachment ◽  
Proline Rich Region

XLαs is a splice variant of the heterotrimeric G protein, Gαs, found on Golgi membranes in cells with regulated and constitutive secretion. We examined the role of the alternatively spliced amino terminus of XLαs for Golgi targeting with the use of subcellular fractionation and fluorescence microscopy. XLαs incorporated [3H]palmitate, and mutation of cysteines in a cysteine-rich region inhibited this incorporation and lessened membrane attachment. Deletion of a proline-rich region abolished Golgi localization of XLαs without changing its membrane attachment. The proline-rich and cysteine-rich regions together were sufficient to target the green fluorescent protein, a cytosolic protein, to Golgi membranes. The membrane attachment and Golgi targeting of the fusion protein required the putative palmitoylation sites, the cysteine residues in the cysteine-rich region. Several peripheral membrane proteins found at the Golgi have proline-rich regions, including a Gαi2 splice variant, dynamin II, βIII spectrin, comitin, and a Golgi SNARE, GS32. Our results suggest that proline-rich regions can be a Golgi-targeting signal for G protein α subunits and possibly for other peripheral membrane proteins as well.

scholarly journals Peripheral membrane proteins: FYVE sticky fingers

1999 ◽  
Vol 9 (22) ◽  
pp. R857-R860 ◽  
Author(s):  
Paul C. Driscoll ◽  
Anne-Lise Vuidepot
Keyword(s):  
Membrane Proteins ◽  
Peripheral Membrane Proteins

scholarly journals Dynamic Structure Formation of Peripheral Membrane Proteins

2011 ◽  
Vol 7 (6) ◽  
pp. e1002067 ◽  
Author(s):  
Diana Morozova ◽  
Gernot Guigas ◽  
Matthias Weiss
Keyword(s):  
Membrane Proteins ◽  
Structure Formation ◽  
Dynamic Structure ◽  
Peripheral Membrane Proteins
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