scholarly journals Update on Bone Grafting Materials Used in Dentistry in the Bone Healing Process: Our Experience from Translational Studies to Their Clinical Use

2018 ◽  
Author(s):  
Gretel G. Pellegrini ◽  
Andrea S. Mattiuzzi ◽  
Miguel A. Pellegrini ◽  
Luis A. Corso ◽  
Cintya P. Contreras Morales ◽  
...  
Keyword(s):  
Bone Healing ◽  
Bone Grafting ◽  
Healing Process ◽  
Clinical Use ◽  
Bone Grafting Materials ◽  
Bone Healing Process ◽  
Translational Studies ◽  
Materials Used ◽  
Grafting Materials

scholarly journals Effect of platelet-rich plasma on implant bone defects in rabbits through the FAK/PI3K/AKT signaling pathway

2019 ◽  
Vol 14 (1) ◽  
pp. 311-317
Author(s):  
Wei Liu ◽  
Ben Chen ◽  
Youyang Zheng ◽  
Yuehua Shi ◽  
Zhuojin Shi
Keyword(s):  
Growth Factor ◽  
Bone Healing ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Bone Defects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Tissue Healing ◽  
Bone Healing Process

AbstractPlatelet-rich plasma (PRP) has been shown to be a beneficial growth factor for bone tissue healing and is used in implantology. The aim of this study was to investigate the effects of PRP on bone defects in rabbits. Twenty rabbits were used to establish the implant bone defect model in this study. An intrabony defect (5mm × 5mm × 3mm) was created in alveolar bone in the lower jar of each rabbit. The wound was treated with PRP. The expression of platelet-derived growth factor BB (PDGFBB) was assessed by enzyme-linked immunosorbent assay (ELISA). Focal adhesion kinase (FAK) and related phosphatidylinositol 3-kinase (PI3K)/AKT (protein kinase B) levels were measured by Western blot. The results show that PRP could significantly improve the bone healing process when compared with control, and 10% PRP could markedly increase fibroblast proliferation 48-h post treatment. PDGFBB was higher in the PRP group than that in the control group. PRP treatment also could elevate the phosphorylation of FAK and PI3K/AKT, although the inhibitor of PDGFR could reverse this trend. These results suggest that PRP treatment improves the bone healing process through the FAK/PI3K/AKT pathway.

Maxillofacial Bone Grafting Materials

2021 ◽  
Vol 65 (1) ◽  
pp. 167-195
Author(s):  
Nabil Moussa ◽  
Yijiao Fan ◽  
Harry Dym
Keyword(s):  
Bone Grafting ◽  
Bone Grafting Materials ◽  
Grafting Materials
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