scholarly journals Body Mass Index and Colorectal Cancer

2019 ◽  
Author(s):  
Nuri Faruk Aykan ◽  
Mehmet Artac ◽  
Tahsin Özatli
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Mass

scholarly journals Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3592
Author(s):  
Chong-Chi Chiu ◽  
Chung-Han Ho ◽  
Chao-Ming Hung ◽  
Chien-Ming Chao ◽  
Chih-Cheng Lai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Survival Rates ◽  
Normal Weight ◽  
P Value ◽  
Administrative Claims ◽  
The Impact

It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients’ long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan–Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53–1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43–1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50–24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00–29.99 kg/m2), class I obesity (30.00–34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.

scholarly journals Analysis of Body Mass Index and Mortality in Patients With Colorectal Cancer Using Causal Diagrams

JAMA Oncology ◽  
2016 ◽  
Vol 2 (9) ◽  
pp. 1137 ◽  
Author(s):  
Candyce H. Kroenke ◽  
Romain Neugebauer ◽  
Jeffrey Meyerhardt ◽  
Carla M. Prado ◽  
Erin Weltzien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Causal Diagrams

Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis

2014 ◽  
Vol 25 (10) ◽  
pp. 1407-1418 ◽  
Author(s):  
Sabrina Schlesinger ◽  
Sabine Siegert ◽  
Manja Koch ◽  
Jessica Walter ◽  
Nils Heits ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Prospective Study ◽  
Cancer Survivors ◽  
Body Mass ◽  
Meta Analysis ◽  
Colorectal Cancer Survivors ◽  
Risk Of Mortality ◽  
A Prospective Study

scholarly journals Association between Body Mass Index and Prognosis of Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120706 ◽  
Author(s):  
Junga Lee ◽  
Jeffrey A. Meyerhardt ◽  
Edward Giovannucci ◽  
Justin Y. Jeon
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cohort Studies ◽  
Body Mass ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Prospective Cohort Studies

scholarly journals Body mass index (BMI) trajectories and risk of colorectal cancer in the PLCO cohort

2018 ◽  
Vol 119 (1) ◽  
pp. 130-132 ◽  
Author(s):  
Rui Zheng ◽  
Mulong Du ◽  
Baoguo Zhang ◽  
Junyi Xin ◽  
Haiyan Chu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Bmi Trajectories

scholarly journals Colorectal cancer risk based on extended family history and body mass index

2020 ◽  
Vol 44 (7) ◽  
pp. 778-784 ◽  
Author(s):  
Heather M. Ochs‐Balcom ◽  
Priyanka Kanth ◽  
James M. Farnham ◽  
Samir Abdelrahman ◽  
Lisa A. Cannon‐Albright
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Family History ◽  
Cancer Risk ◽  
Body Mass ◽  
Extended Family ◽  
Colorectal Cancer Risk

scholarly journals Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants

2020 ◽  
Vol 113 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Peter T Campbell ◽  
Yi Lin ◽  
Stephanie A Bien ◽  
Jane C Figueiredo ◽  
Tabitha A Harrison ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Statistical Tests ◽  
Single Step ◽  
Degree Of Freedom ◽  
Colorectal Cancer Risk ◽  
Cancer Case ◽  
Test Procedures

Abstract Background Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk. Methods We tested multiplicative statistical interactions between BMI (per 5 kg/m2) and approximately 2.7 million single nucleotide polymorphisms with colorectal cancer risk among 14 059 colorectal cancer case (53.2% women) and 14 416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included 2-step (ie, Cocktail method) and single-step (ie, case-control logistic regression and a joint 2-degree of freedom test) procedures. All statistical tests were two-sided. Results Each 5 kg/m2 increase in BMI was associated with higher risks of colorectal cancer, less so for women (odds ratio [OR] = 1.14, 95% confidence intervals [CI] = 1.11 to 1.18; P = 9.75 × 10–17) than for men (OR = 1.26, 95% CI = 1.20 to 1.32; P = 2.13 × 10–24). The 2-step Cocktail method identified an interaction for women, but not men, between BMI and a SMAD7 intronic variant at 18q21.1 (rs4939827; Pobserved = .0009; Pthreshold = .005). A joint 2-degree of freedom test was consistent with this finding for women (joint P = 2.43 × 10–10). Each 5 kg/m2 increase in BMI was more strongly associated with colorectal cancer risk for women with the rs4939827-CC genotype (OR = 1.24, 95% CI = 1.16 to 1.32; P = 2.60 × 10–10) than for women with the CT (OR = 1.14, 95% CI = 1.09 to 1.19; P = 1.04 × 10–8) or TT (OR = 1.07, 95% CI = 1.01 to 1.14; P = .02) genotypes. Conclusion These results provide novel insights on a potential mechanism through which a SMAD7 variant, previously identified as a susceptibility locus for colorectal cancer, and BMI may influence colorectal cancer risk for women.

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