scholarly journals OCT in Lamellar Corneal Transplantation

2018 ◽  
Author(s):  
Mehmet Cüneyt Özmen ◽  
Hüseyin Baran Özdemir
Keyword(s):  
Corneal Transplantation

Autosomal recessive congenital hereditary corneal dystrophy associated with a novel SLC4A11 mutation in two consanguineous Tunisian families

2021 ◽  
pp. bjophthalmol-2020-318204
Author(s):  
Zohra Chibani ◽  
Imen Zone Abid ◽  
Peter Söderkvist ◽  
Jamel Feki ◽  
Mounira Hmani Aifa
Keyword(s):  
Autosomal Recessive ◽  
Corneal Transplantation ◽  
Gene Mutations ◽  
In Silico Analysis ◽  
Corneal Dystrophy ◽  
Solute Carrier Family ◽  
Transporter Protein ◽  
Bicarbonate Transporter ◽  
Corneal Clouding ◽  
Solute Carrier

BackgroundAutosomal recessive congenital hereditary corneal dystrophy (CHED) is a rare isolated developmental anomaly of the eye characterised by diffuse bilateral corneal clouding that may lead to visual impairment requiring corneal transplantation. CHED is known to be caused by mutations in the solute carrier family 4 member 11 (SLC4A11) gene which encodes a membrane transporter protein (sodium bicarbonate transporter-like solute carrier family 4 member 11).MethodsTo identify SLC4A11 gene mutations associated with CHED (OMIM: #217700), genomic DNA was extracted from whole blood and sequenced for all exons and intron-exon boundaries in two large Tunisian families.ResultsA novel deletion SLC4A11 mutation (p. Leu479del; c.1434_1436del) is responsible for CHED in both analysed families. This non-frameshift mutation was found in a homozygous state in affected members and heterozygous in non-affected members. In silico analysis largely support the pathogenicity of this alteration that may leads to stromal oedema by disrupting the osmolarity balance. Being localised to a region of alpha-helical secondary structure, Leu479 deletion may induce protein-compromising structural rearrangements.ConclusionTo the best of our knowledge, this is the first clinical and genetic study exploring CHED in Tunisia. The present work also expands the list of pathogenic genotypes in SLC4A11 gene and its associated clinical diagnosis giving more insights into genotype–phenotype correlations.

Incidence of Fungal Infection in Positive Donor Rim Cultures after Corneal Transplantation

2021 ◽  
pp. 1-5
Author(s):  
Julia Shatten ◽  
Roheena Kamyar ◽  
Deepinder Dhaliwal ◽  
Regis P. Kowalski ◽  
Vishal Jhanji
Keyword(s):  
Fungal Infection ◽  
Corneal Transplantation

Effects of anti-inflammatory and immunosuppressive drugs on the heterolamellar corneal transplantation in rabbits

1990 ◽  
Vol 9 (8) ◽  
pp. 749-757 ◽  
Author(s):  
Ajuan Guo ◽  
Ekanem Ohia ◽  
Jintang Xu ◽  
Parimal Bhattacherjee ◽  
Prasad Kulkarni
Keyword(s):  
Corneal Transplantation ◽  
Immunosuppressive Drugs ◽  
Anti Inflammatory

Prognosis and Management of Corneal Transplantation for Herpetic Keratitis

1980 ◽  
Vol 98 (10) ◽  
pp. 1755-1759 ◽  
Author(s):  
L. M. Cobo ◽  
D. J. Coster ◽  
N. S. C. Rice ◽  
B. R. Jones
Keyword(s):  
Corneal Transplantation ◽  
Herpetic Keratitis

Creutzfeldt-Jakob Disease Following Corneal Transplantation

Cornea ◽  
2004 ◽  
Vol 23 (4) ◽  
pp. 406-408 ◽  
Author(s):  
Kristin M Hammersmith ◽  
Elisabeth J Cohen ◽  
Christopher J Rapuano ◽  
Peter R Laibson
Keyword(s):  
Corneal Transplantation ◽  
Jakob Disease

Targeted corneal transplantation

2012 ◽  
Vol 23 (4) ◽  
pp. 324-329 ◽  
Author(s):  
Vishal Jhanji ◽  
Jod S. Mehta ◽  
Namrata Sharma ◽  
Bhavana Sharma ◽  
Rasik B. Vajpayee
Keyword(s):  
Corneal Transplantation
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