Biotransformation of Bisphenol A and Its Adverse Effects on the Next Generation

Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation

Environment International ◽

10.1016/j.envint.2021.106730 ◽

2021 ◽

Vol 156 ◽

pp. 106730

Author(s):

Alexandra Schaffert ◽

Laura Krieg ◽

Juliane Weiner ◽

Rita Schlichting ◽

Elke Ueberham ◽

...

Keyword(s):

Adverse Effects ◽

Bisphenol A ◽

Adipocyte Differentiation ◽

Human Adipocyte

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Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

Toxicology ◽

10.1016/j.tox.2014.08.006 ◽

2014 ◽

Vol 325 ◽

pp. 133-143 ◽

Cited By ~ 56

Author(s):

Alice Marmugi ◽

Frederic Lasserre ◽

Diane Beuzelin ◽

Simon Ducheix ◽

Laurence Huc ◽

...

Keyword(s):

Adverse Effects ◽

Bisphenol A

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Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats

Human & Experimental Toxicology ◽

10.1177/09603271211053285 ◽

2021 ◽

pp. 096032712110532

Author(s):

Manigandan Nagarajan ◽

Boobalan Raja ◽

Jeganathan Manivannan

Keyword(s):

Adverse Effects ◽

Bisphenol A ◽

Thiobarbituric Acid ◽

Environmental Pollutant ◽

Ros Generation ◽

Thiobarbituric Acid Reactive Substances ◽

Hypertensive Rats ◽

Liver And Kidney ◽

Ace Activity ◽

Safe Dose

Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and “safe” dose of bisphenol A (BPA) under hypertensive conditions. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME, 40 mg/kg b.w/day) induced hypertensive Wistar rats to BPA (50 μg/kg b.w/day) by oral administration along with appropriate controls for 30 days period. The results illustrate that a ‘safe’ dose of BPA does not influence the systolic blood pressure (SBP) and levels of circulatory biomarkers of tissue damage. On the other hand, BPA exposure significantly ( p < 0.05) elevates the thiobarbituric acid reactive substances (TBARS) content in plasma and tissues (heart, aorta, liver and kidney) in hypertensive rats when compared with respective control (BPA alone exposed) rats. Similarly, a significant modulation of ROS generation in RBC, plasma nitric oxide (NO) level and angiotensin-converting enzyme (ACE) activity was observed only under hypertensive milieu. In conclusion, the observed adverse effects during ‘safe’ dose of BPA exposure are specific to the hypertensive condition. Therefore, a precise investigation to explore the effects of BPA exposure in vulnerable hypertensive populations is highly suggested.

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Adverse Effects of Bisphenol A on Male Reproductive Function

Reviews of Environmental Contamination and Toxicology - Reviews of Environmental Contamination and Toxicology Volume 228 ◽

10.1007/978-3-319-01619-1_3 ◽

2013 ◽

pp. 57-82 ◽

Cited By ~ 19

Author(s):

Faustin Pascal Tsagué Manfo ◽

Rajamanickam Jubendradass ◽

Edouard Akono Nantia ◽

Paul Fewou Moundipa ◽

Premendu Prakash Mathur

Keyword(s):

Adverse Effects ◽

Bisphenol A ◽

Reproductive Function ◽

Male Reproductive Function

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Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice

10.21203/rs.2.17347/v1 ◽

2019 ◽

Author(s):

Yann Malaisé ◽

Corinne Lencina ◽

Christel Cartier ◽

Maïwenn Olier ◽

Sandrine Ménard ◽

...

Keyword(s):

Adverse Effects ◽

Immune Responses ◽

Bisphenol A ◽

Low Dose ◽

Intestinal Barrier ◽

Female Offspring ◽

Oral Exposure ◽

Gut Barrier ◽

Cellular Immune Responses ◽

Cellular Immune

Abstract Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during perinatal period (gestation and/or lactation). We previously demonstrated that perinatal oral exposure to BPA (via gavage of mothers during gestation and lactation) has long-term consequences on immune response and intestinal barrier functions. Due to its adverse effects on several developmental and physiological processes, BPA was removed from consumer products and replaced by chemical substitutes such as BPS or BPF, that are structurally similar and not well studied compare to BPA. Here, we aimed to compare perinatal oral exposure to these bisphenols (BPs) at two doses (5 and 50 mg/kg body weight (BW)/day (d)) on gut barrier and immune system in female offspring mice at adulthood (Post Natal Day PND70). Methods Pregnant female mice were orally exposed to BPA, BPS or BPF at 5 or 50 μg/kg BW/d from 15th day of gravidity to weaning of pups at PostNatal Day (PND) 21. Gut barrier function and the humoral and cellular immune responses of adult offspring (PND70) were analysed at intestinal and systemic levels. Results In female offspring, perinatal oral BP exposure led to adverse effects on intestinal barrier and immune response that were dependant of the BP nature (A, S or F) and dose of exposure. Stronger impacts were observed with BPS at the dose of 5µg/kg BW/d on inflammatory markers in feces associated with an increase of anti-E. coli IgG, revealing a defect of gut barrier. BPA and BPF exposure induced prominent changes at low dose in offspring mice, in term of gut barrier functions and cellular immune responses, provoking an intestinal and systemic Th1/Th17 inflammation. Conclusion These findings provide, for the first time, a comparative study of long-time consequences of BPA, S and F perinatal exposure by oral route in offspring mice. This work warms that it is mandatory to consider immune markers and dose in risk assessment associated to new BPA’s alternatives. Keywords: Bisphenol A, Bisphenol S, Bisphenol F, Immune responses, Perinatal exposure, Intestine, Th1/Th17, immunoglobulin, cytokines

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Hydrogen Is Promising for Medical Applications

Clean Technologies ◽

10.3390/cleantechnol2040033 ◽

2020 ◽

Vol 2 (4) ◽

pp. 529-541

Author(s):

Shin-ichi Hirano ◽

Yusuke Ichikawa ◽

Bunpei Sato ◽

Fumitake Satoh ◽

Yoshiyasu Takefuji

Keyword(s):

Energy Source ◽

Adverse Effects ◽

Wide Spectrum ◽

Current Medical ◽

The Body ◽

Medical Applications ◽

Water Production ◽

Next Generation ◽

Living Body ◽

Highly Active

Hydrogen (H2) is promising as an energy source for the next generation. Medical applications using H2 gas can be also considered as a clean and economical technology. Since the H2 gas based on electrolysis of water production has potential to expand the medical applications, the technology has been developed in order to safely dilute it and to supply it to the living body by inhalation, respectively. H2 is an inert molecule which can scavenge the highly active oxidants including hydroxyl radical (·OH) and peroxynitrite (ONOO−), and which can convert them into water. H2 is clean and causes no adverse effects in the body. The mechanism of H2 is different from that of traditional drugs because it works on the root of many diseases. Since H2 has extensive and various effects, it may be called a “wide spectrum molecule” on diseases. In this paper, we reviewed the current medical applications of H2 including its initiation and development, and we also proposed its prospective medical applications. Due to its marked efficacy and no adverse effects, H2 will be a next generation therapy candidate for medical applications.

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Adverse effects of bisphenol A (BPA) on the dopamine system in two distinct cell models and corpus striatum of the Sprague-Dawley rat

Journal of Toxicology and Environmental Health Part A ◽

10.1080/15287394.2016.1204577 ◽

2016 ◽

Vol 79 (20) ◽

pp. 912-924 ◽

Cited By ~ 4

Author(s):

Brittney A. Nowicki ◽

Matt A. Hamada ◽

Gina Y. Robinson ◽

Douglas C. Jones

Keyword(s):

Adverse Effects ◽

Bisphenol A ◽

Corpus Striatum ◽

Cell Models ◽

Sprague Dawley ◽

Dopamine System ◽

Sprague Dawley Rat ◽

Distinct Cell

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AMELIORATIVE EFFECT OF PUMPKIN SEED OIL AGAINST THE BISPHENOL-A ADVERSE EFFECTS IN MALE MICE.

Al-Azhar Journal of Pharmaceutical Sciences ◽

10.21608/ajps.2018.6641 ◽

2018 ◽

Vol 54 (2) ◽

pp. 159-173

Keyword(s):

Adverse Effects ◽

Bisphenol A ◽

Seed Oil ◽

Male Mice ◽

Pumpkin Seed ◽

Ameliorative Effect ◽

Pumpkin Seed Oil

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Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

The Open Biotechnology Journal ◽

10.2174/1874070701610010122 ◽

2016 ◽

Vol 10 (1) ◽

pp. 122-130 ◽

Cited By ~ 7

Author(s):

Ciro Menale ◽

Damiano G. Mita ◽

Nadia Diano ◽

Sabrina Diano

Keyword(s):

Insulin Resistance ◽

Glucose Metabolism ◽

Adverse Effects ◽

Bisphenol A ◽

Estrogenic Activity ◽

Endocrine Function ◽

Peripheral Tissues ◽

Metabolism Regulation

Bisphenol A (BPA) is used as basic chemical compound in the production of polycarbonate food containers or epoxy resins coating metallic cans for food and beverages conservation. Its xeno-estrogenic activity alters endocrine-metabolic pathways modulating glucose metabolism and increasing the risk of developing diabetes, insulin resistance, and obesity. Based on in vitro and in vivo experimental research, here we report some of the major BPA adverse effects on tissues that play a key role in the regulation on the whole body’s metabolism. Evidences have shown that BPA is able to exert its endocrine disrupting action altering glucose metabolism and contributing to the onset of metabolic disorders, acting on liver functions and affecting insulin production by the pancreas. Exposure to BPA has been reported also to modulate glucose utilization in muscles, as well as to interfere with adipose tissue endocrine function. In addition, to peripheral tissues, recent studies have shown that BPA by acting in the Central Nervous System affects neuroendocrine regulation of glucose metabolism, promoting glucose metabolism dysfunction such as glucose intolerance and insulin resistance. Thus, exposure to BPA seems to be an important risk factor in the onset of obesity and metabolic syndrome. However, its mechanisms of action need to be further investigated to provide a major evaluation of risk assessment.

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