scholarly journals Therapeutic Strategies of Secretome of Mesenchymal Stem Cell

Author(s):  
Daniel Ascencio González ◽  
Rogelio Hernández Pando ◽  
Miguel Ángel Gómez Lim ◽  
Sergio Ayala Fraustro ◽  
Aaron Torres Garcia
2020 ◽  
Vol 12 (8) ◽  
pp. 814-840
Author(s):  
Zhan-Jun Ma ◽  
Jing-Jing Yang ◽  
Yu-Bao Lu ◽  
Zhao-Yang Liu ◽  
Xue-Xi Wang

2017 ◽  
Vol 18 (9) ◽  
pp. 1852 ◽  
Author(s):  
Francisco Vizoso ◽  
Noemi Eiro ◽  
Sandra Cid ◽  
Jose Schneider ◽  
Roman Perez-Fernandez

2020 ◽  
Vol 13 (12) ◽  
pp. 423
Author(s):  
Amerigo Giudice ◽  
Alessandro Antonelli ◽  
Emanuela Chiarella ◽  
Francesco Baudi ◽  
Tullio Barni ◽  
...  

Bisphosphonates-related osteonecrosis of the jaw (BRONJ) was firstly reported by Marx in 2003. Since 2014, the term medication-related osteonecrosis of the jaw (MRONJ) is recommended by the American Association of Oral and Maxillofacial Surgeons (AAOMS). Development of MRONJ has been associated to the assumption of bisphosphonates but many MRONJ-promoting factors have been identified. A strong involvement of immunity components has been suggested. Therapeutic intervention includes surgical and non-surgical treatments, as well as regenerative medicine procedures for the replacement of the lost tissues. The literature confirms that the combination of mesenchymal stem cells (MSCs), biomaterials and local biomolecules can support the regeneration/repair of different structures. In this review, we report the major open topics in the pathogenesis of MRONJ. Then, we introduce the oral tissues recognized as sources of MSCs, summing up in functional terms what is known about the exosomes release in physiological and pathological conditions.


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