scholarly journals Gateway Reflex: A Neuro-Immune Crosstalk for Organ-Specific Disease Development

2019 ◽  
Author(s):  
Daisuke Kamimura ◽  
Yuki Tanaka ◽  
Takuto Ohki ◽  
Masaaki Murakami
Keyword(s):  
Disease Development ◽  
Specific Disease ◽  
Organ Specific

scholarly journals Generation ofN-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models

2009 ◽  
Vol 94 (4) ◽  
pp. 412-421 ◽  
Author(s):  
Bernhard Aigner ◽  
Birgit Rathkolb ◽  
Matthias Klaften ◽  
Reinhard Sedlmeier ◽  
Martina Klempt ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Disease Models ◽  
Plasma Enzyme ◽  
Specific Disease ◽  
Mouse Mutants ◽  
Organ Specific

scholarly journals Organ-Specific Disease Provoked by Systemic Autoimmunity

Cell ◽  
1996 ◽  
Vol 87 (5) ◽  
pp. 811-822 ◽  
Author(s):  
Valérie Kouskoff ◽  
Anne-Sophie Korganow ◽  
Véronique Duchatelle ◽  
Claude Degott ◽  
Christophe Benoist ◽  
...  
Keyword(s):  
Specific Disease ◽  
Systemic Autoimmunity ◽  
Organ Specific

scholarly journals Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Xueli Fan ◽  
Hongliang Zhang ◽  
Yun Cheng ◽  
Xinmei Jiang ◽  
Jie Zhu ◽  
...  
Keyword(s):  
Animal Models ◽  
Immune Cells ◽  
Innate Immune System ◽  
Innate Immune ◽  
Disease Development ◽  
Cell Type ◽  
Organ Specific ◽  
Anti Inflammatory ◽  
Inflammatory Macrophages ◽  
Lines Of Evidence

Macrophages are important immune cells of the innate immune system that are involved in organ-specific homeostasis and contribute to both pathology and resolution of diseases including infections, cancer, obesity, atherosclerosis, and autoimmune disorders. Multiple lines of evidence point to macrophages as a remarkably heterogeneous cell type. Different phenotypes of macrophages exert either proinflammatory or anti-inflammatory roles depending on the cytokines and other mediators that they are exposed to in the local microenvironment. Proinflammatory macrophages secrete detrimental molecules to induce disease development, while anti-inflammatory macrophages produce beneficial mediators to promote disease recovery. The conversion of the phenotypes of macrophages can regulate the initiation, development, and recovery of autoimmune diseases. Human neuroimmune diseases majorly include multiple sclerosis (MS), neuromyelitis optica (NMO), myasthenia gravis (MG), and Guillain-Barré syndrome (GBS) and macrophages contribute to the pathogenesis of these neuroimmune diseases. In this review, we summarize the double roles of macrophage in neuroimmune diseases and their animal models to further explore the mechanisms of macrophages involved in the pathogenesis of these disorders, which may provide a potential therapeutic approach for these disorders in the future.

1329: Identification of Candidate Stromal Mesenchyme Cell Genes Associated With the Organ-Specific Differentiation of Epithelial

2004 ◽  
Vol 171 (4S) ◽  
pp. 350-350
Author(s):  
Young Ah Goo ◽  
Eugene Yi ◽  
Carrie M. Sorensen ◽  
Leroy E. Hood ◽  
Alvin Y. Liu
Keyword(s):  
Specific Differentiation ◽  
Organ Specific ◽  
Mesenchyme Cell
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