scholarly journals Gene Polymorphisms Associated with Atrial Fibrillation

2018 ◽  
Author(s):  
Nevra Alkanli ◽  
Arzu Ay ◽  
Suleyman Serdar Alkanli
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphisms

scholarly journals Influence of ABCB1 and CYP3A5 gene polymorphisms on pharmacokinetics of apixaban in patients with atrial fibrillation and acute stroke

2018 ◽  
Vol Volume 11 ◽  
pp. 43-49 ◽  
Author(s):  
Alexander Valerevich Kryukov ◽  
Dmitry Alekseevich Sychev ◽  
Denis Anatolevich Andreev ◽  
Kristina Anatolievna Ryzhikova ◽  
Elena Anatolievna Grishina ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Acute Stroke ◽  
Gene Polymorphisms ◽  
Em Gene

MMP-2 and TIMP-2 gene polymorphisms and susceptibility to atrial fibrillation in Chinese Han patients with hypertensive heart disease

2010 ◽  
Vol 411 (9-10) ◽  
pp. 719-724 ◽  
Author(s):  
Xiaobo Gai ◽  
Zhigang Zhang ◽  
Yonggang Liang ◽  
Zheming Chen ◽  
Xiangyue Yang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Gene Polymorphisms ◽  
Hypertensive Heart Disease ◽  
Chinese Han

Renin-angiotensin system–related gene polymorphisms are associated with risk of atrial fibrillation

2010 ◽  
Vol 160 (3) ◽  
pp. 496-505 ◽  
Author(s):  
Peilin Xiao ◽  
Zhiyu Ling ◽  
Kamsang Woo ◽  
Huaan Du ◽  
Li Su ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphisms ◽  
Renin Angiotensin System ◽  
Related Gene ◽  
Angiotensin System ◽  
Renin Angiotensin

Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population

2021 ◽  
pp. 109980042110293
Author(s):  
Ilhem Gouissem ◽  
Fatma Midani ◽  
Hayet Soualmia ◽  
Meryem Bouchemi ◽  
Sana Ouali ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Genotype Distribution ◽  
Confounding Factors ◽  
Pcr Rflp ◽  
Study Population ◽  
Polymerase Chain ◽  
And Control ◽  
T Haplotype

Background: This study investigated the association of angiotensin–converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin–angiotensin–aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population. Materials and Methods: The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively. Results: The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants ( p < 0.01 and p < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39–8.34]; p < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48–21.98]; p < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62–8.27]; p < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22–5.86]; p < 0.01). After adjusting for confounding factors (age, diabetes, hypertension and dyslipidemia), the risk remained higher for the TT genotype (OR = 3.58; 95% CI [1.08–11.77]; p < 0.03). Furthermore, the haplotype–based association of the ACE I/D and CYP11B2-344C/T polymorphisms showed that the D-T haplotype increased the risk for AF. Conclusion: Our study suggests a significant association of the ACE (I/D) and CYP11B2-344C/T polymorphisms with AF in the Tunisian population.

Sign in / Sign up

Export Citation Format

Share Document