scholarly journals Arthroscopic Technique to Treat Articular Cartilage Lesions in the Patellofemoral Joint

2018 ◽  
Author(s):  
Anell Olivos-Meza ◽  
Antonio Madrazo-Ibarra ◽  
Clemente Ibarra Ponce de León
Keyword(s):  
Articular Cartilage ◽  
Patellofemoral Joint ◽  
Arthroscopic Technique ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

scholarly journals Comparative Outcomes for Treatment of Articular Cartilage Lesions in the Ankle with Particulated Juvenile Cartilage Allograft

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0000
Author(s):  
James Deal ◽  
Robert Turner ◽  
Paul Ryan ◽  
Claude Anderson ◽  
Adam Groth
Keyword(s):  
Articular Cartilage ◽  
Outcome Measures ◽  
Lesion Length ◽  
Open Approach ◽  
Osteochondral Defects ◽  
Open Technique ◽  
Arthroscopic Technique ◽  
Cartilage Lesions ◽  
Significant Difference ◽  
Articular Cartilage Lesions

Category: Ankle Introduction/Purpose: Treatment of osteochondral defects of the talus with particulated juvenile cartilage allograft is a relatively new procedure. Although other treatment options exist for large osteochondral defects of the talus, the potential advantage of particulated juvenile allograft is the ability to perform the procedure arthroscopically or through a minimal approach. No previous studies have looked at the results of an arthroscopic approach and no previous studies have compared an arthroscopic technique to an open approach. The purpose of this study was to compare the outcomes of an arthroscopic transfer technique to the previously published open technique. Methods: A total of 34 patients underwent treatment of talar cartilage lesions with juvenile particulated cartilage allograft. Twenty of these were done arthroscopically and 14 were done with an open arthrotomy. There was no statistically significant difference between the groups with respect to age, lesion width, lesion depth, lesion length, or operative time. Scores for 6 different validated outcome measures were recorded for patients in each group pre-operatively and subsequently at 6 months, 1 year, 18 months, and 2 years. Results: Comparing outcome measurements at each data point to baseline, there were no statistically significant post-operative differences found between open and arthroscopic approaches with regards to VAS Pain Scale, AOFAS Ankle-Hindfoot Scale, Foot and Ankle Ability Measure - Sport Scale, or SF12 Physical Health Scale. Conclusion: Treatment of talar articular cartilage lesions with particulated juvenile cartilage allograft is associated with improved outcomes at 2 years with regards to several validated outcome measures regardless of technique utilized. At 2 years follow up, there were no statistically significant differences in outcomes utilizing an arthroscopic technique versus open technique with the numbers given. This data supports the use of particulated juvenile cartilage allograft utilizing either arthroscopic or open techniques.

Articular Cartilage Lesions of the Patellofemoral Joint in Dogs With Naturally Occurring Cranial Cruciate Ligament Disease

2014 ◽  
Vol 43 (3) ◽  
pp. 308-315 ◽  
Author(s):  
Kimberly A. Agnello ◽  
Ian G. Holsworth ◽  
Ana Vanessa Caceres ◽  
Dorothy Cimino Brown ◽  
Jeffrey J. Runge ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Patellofemoral Joint ◽  
Cruciate Ligament ◽  
Cranial Cruciate Ligament ◽  
Cartilage Lesions ◽  
Naturally Occurring ◽  
Cranial Cruciate Ligament Disease ◽  
Articular Cartilage Lesions

scholarly journals POS0277 ANABOLIC EFFECT OF LNA043, A NOVEL DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE: RESULTS FROM AN IMAGING-BASED PROOF-OF-CONCEPT TRIAL IN PATIENTS WITH FOCAL ARTICULAR CARTILAGE LESIONS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 363.2-363
Author(s):  
S. Trattnig ◽  
C. Scotti ◽  
D. Laurent ◽  
V. Juras ◽  
S. Hacker ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Weight Bearing ◽  
Cartilage Lesion ◽  
Cartilage Volume ◽  
Lesion Volume ◽  
Proof Of Concept ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

Background:LNA043 is a modified, recombinant version of the human angiopoietin-like 3 (ANGPTL3) protein acting directly on cartilage-resident cells to transmit its cartilage anabolic effect. A first-in-human study previously demonstrated the favourable safety profile and the modulation of several pathways involved in cartilage homeostasis and osteoarthritis (OA)1. A previous proof-of-mechanism imaging study used high field (7 Tesla) magnetic resonance imaging (MRI) to show formation of hyaline-like tissue after a single injection of 20 mg LNA043 (unpublished data).Objectives:To evaluate non-invasively the chondro-regenerative capacity of multiple intra-articular (i.a.) injections of LNA043 in patients with articular cartilage lesions in the knee (NCT03275064).Methods:This was a randomised, double-blind, placebo (PBO)-controlled, proof-of-concept study in patients with a partial thickness cartilage lesion. In total, 58 patients (43 [20 mg LNA043]; 15 [PBO]), stratified by lesion type (condylar or patellar) were treated with 4 weekly i.a. injections. The primary endpoint was T2 relaxation time measurement as a marker of collagen fiber network, and cartilage lesion-volume was a secondary endpoint, both using 3-Tesla MRI. Assessments were performed at baseline, weeks (wks) 8, 16, 28 and 52 (the latter in 23/58 patients). While lesion-volume for the secondary endpoint was determined from manually segmented images, the cartilage volume of 21 sub-regions spanning the entire knee was also measured from 3D isotropic MR images employing an automated segmentation prototype software (MR Chondral Health 2.1 [MRCH], Siemens Healthcare)2. An exploratory analysis evaluated the treatment effect for the additive volume of the 3 subregions in the weight-bearing area of the medial femur.Results:No change in T2 relaxation time was detected between treatment and PBO groups. Manual segmentation showed continuous filling of the cartilage lesions up to wk 28 in LNA043-treated patients with femoral lesions (p=0.08, vs PBO) while no effect was detected for patients with patellar lesions. Given the limitations of measuring small, irregularly shaped lesions with manual image-analysis, the MRCH approach was used (Figure 1). In the medial femoral weight-bearing region, refilling was detected over time (Δ=123 mm3 at wk 28, N= 37, p= 0.05). No overgrowth was detected in the lateral femoral condyles without cartilage damage. The overall safety profile was favourable; only mild/moderate local reactions were reported, including a higher incidence of joint swelling (9.3% vs 0%) and arthralgia (11.6% vs 6.7%) for LNA043 vs PBO resolving spontaneously or with paracetamol/NSAIDs. No anti-drug antibodies were detected.Conclusion:Treatment with 4 weekly i.a. injections of 20 mg LNA043 resulted in regeneration of damaged cartilage in patients with femoral articular cartilage lesions. Automated measurement of cartilage volume in the femoral index region was able to detect a relevant treatment effect and was found to be more sensitive than the manual segmentation method. No sign of cartilage overgrowth was observed in healthy femoral regions. A Phase 2b study in patients with mild to moderate knee OA is in preparation.References:[1]Scotti et al. ACR Convergence 2020; Abstract #1483[2]Juras et al. Cartilage 2020; Sep 29:1-12Disclosure of Interests:Siegfried Trattnig: None declared, Celeste Scotti Shareholder of: Novartis, Employee of: Novartis, Didier Laurent Shareholder of: Novartis, Employee of: Novartis, Vladimir Juras: None declared, Scott Hacker Grant/research support from: Novartis, Brian Cole: None declared, Libor Pasa: None declared, Roman Lehovec: None declared, Pavol Szomolanyi: None declared, Esther Raithel Employee of: Siemens Healthcare GmbH, Franziska Saxer Shareholder of: Novartis, Employee of: Novartis, Jens Praestgaard Shareholder of: Novartis, Employee of: Novartis, Fabiola La Gamba Shareholder of: Novartis, Employee of: Novartis, José L. Jiménez Employee of: Novartis, David Sanchez Ramos Shareholder of: Novartis, Employee of: Novartis, Ronenn Roubenoff Shareholder of: Novartis, Employee of: Novartis, Matthias Schieker Shareholder of: Novartis, Employee of: Novartis

Articular cartilage lesions of the knee following immobilisation or destabilisation for 6 or 12 weeks in rabbits

1998 ◽  
Vol 17 (3) ◽  
pp. 227-233 ◽  
Author(s):  
L. L. K. Fu ◽  
N. Maffulli ◽  
K. M. H. Yip ◽  
K. M. Chan
Keyword(s):  
Articular Cartilage ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

scholarly journals P35 Articular cartilage lesions: a review of 25,124 knee arthroscopies

2007 ◽  
Vol 15 ◽  
pp. B96
Author(s):  
W. Widuchowski ◽  
J. Widuchowski ◽  
T. Trzaska ◽  
R. Faltus ◽  
P. àukasik ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

The Evaluation of Articular Cartilage Lesions of the Knee With a 3-Tesla Magnet

2007 ◽  
Vol 23 (5) ◽  
pp. 496-502 ◽  
Author(s):  
Lars Victor von Engelhardt ◽  
Clayton N. Kraft ◽  
Peter H. Pennekamp ◽  
Hans Heinz Schild ◽  
Alfred Schmitz ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
3 Tesla ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions
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