scholarly journals Frameworks for Evaluating Qualitative and Quantitative Information on Adverse Drug Events throughout Development through to Marketing

Author(s):  
Kaori Nomura ◽  
Brian David Edwards
Author(s):  
Jerrold L. Abraham

Inorganic particulate material of diverse types is present in the ambient and occupational environment, and exposure to such materials is a well recognized cause of some lung disease. To investigate the interaction of inhaled inorganic particulates with the lung it is necessary to obtain quantitative information on the particulate burden of lung tissue in a wide variety of situations. The vast majority of diagnostic and experimental tissue samples (biopsies and autopsies) are fixed with formaldehyde solutions, dehydrated with organic solvents and embedded in paraffin wax. Over the past 16 years, I have attempted to obtain maximal analytical use of such tissue with minimal preparative steps. Unique diagnostic and research data result from both qualitative and quantitative analyses of sections. Most of the data has been related to inhaled inorganic particulates in lungs, but the basic methods are applicable to any tissues. The preparations are primarily designed for SEM use, but they are stable for storage and transport to other laboratories and several other instruments (e.g., for SIMS techniques).


Land ◽  
2013 ◽  
Vol 2 (3) ◽  
pp. 508-533 ◽  
Author(s):  
Anette Reenberg ◽  
Issoufou Maman ◽  
Ibrahim Bouzou Moussa ◽  
Bjarne Fog

2017 ◽  
Vol 4 (1) ◽  
pp. 79-85
Author(s):  
Sabina Villón Perero ◽  
Brusela Vásquez Farfán ◽  
Tannia Aguirre Suárez

Las actividades turísticas, en especial los servicios de alojamiento y restauración han mantenido una importante participación en la economía del Ecuador durante los últimos años, a partir de esta premisa se consideró relevante realizar el presente estudio que consiste en el análisis de la evolución del sector en mención y su contribución al desarrollo económico de la comuna Ayangue ubicada en la provincia de Santa Elena. Para ejecutar la investigación de campo se tomó una muestra de establecimientos dedicados a las mencionadas actividades, así como también se realizó un estudio socioeconómico mediante la aplicación de  encuestas y entrevistas las mismas que permitieron  obtener información cualitativa y cuantitativa, cuyos resultados evidenciaron cómo ha  evolucionado este sector y el impacto que ha generado en el desarrollo de la comunidad a través del tiempo, los mismos que reflejaron el incentivo de emprendimientos, la  generación de plazas de trabajo y el mejoramiento del nivel económico y social de los comuneros.  AbstractTourist activities, specially Accommodation and provision of food and beverages services, have had an important participation in the economy of Ecuador in the last years, based on this premise it was considered relevant to carry out the present study, which is an analysis of the sector in question and their contribution to economic development of the Ayangue Commune, in Province of Santa Elena. For perform field investigations, it took a sample of establishments and was performed a socio-economic study, using surveys and interviews, which they allowed to obtain qualitative and quantitative information, whose results showed the evolution of this sector and the impact generated in the community development through time, resulting incentive enterprises, generating jobs and improving the economic and social level of the community members. 


2021 ◽  
Vol 51 (2) ◽  
pp. 311-342
Author(s):  
Thales Augusto Zamberlan Pereira

Abstract The commercial treaty with Britain in 1810, along the authorization of foreign trade in ports in 1808, are among the most important institutional changes in nineteenth century Brazil. The 1810 treaty lowered tariffs for British manufactures while maintaining high tariffs in Britain for Brazilian sugar and coffee. These terms are generally viewed as disastrous for the Brazilian economy, although there is still limited quantitative information about how much the tariff affected the demand for British imports. This paper provides new qualitative and quantitative evidence on the operation and effect of Brazil’s imports tariffs in the period. I find that the effect of the tariffs is different from what traditional literature assumes. First, the monetary instability in the 1820s and conflicts over product price assessment often led the de facto tariff to be higher than the 15 percent established by the treaty. Second, even with higher rates, quantitative analysis shows they did not have decrease imports of British textiles.


2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Justina Namukombo

Zambia’s 2012 report on the United Nations Conference on Sustainable Development (RIO +20) identifies existing opportunities on the country’s transitioning to green economy. The RIO +20 conference of 2012 has resulted in new momentum in addressing problems of sustainable development. However, this article argues that there are practical challenges that require paying attention to, especially those involving women. The article addressed one key question: To what extent can women participate in the transitioning process to green economy in Zambia and what opportunities and challenges exists? The study used document analysis to answer the above question. National policy documents were reviewed to understand interventions on environmental management. Whilst going through the documents, the study used gender analysis frameworks (education, skills, roles in family and society, access to infrastructure) to bring out qualitative and quantitative information on women. Using suggested green economy interventions in the literature as benchmark, qualitative analysis was used to project possible participation of women in green economy activities and possible challenges to be faced. The study found that participation of women will be limited despite existing opportunities because of challenges of access to information and communication technology infrastructures, low educational levels and skills and financial constraints. As Zambia undergoes a transitioning process, these limitations should be addressed in planned green economy policies and interventions to maximise benefits.Keywords: Green economy; Gender; Policies; Strategies; ICT; Zambia


Author(s):  
B. Tourniaire ◽  
J. M. Seiler ◽  
J. M. Bonnet ◽  
M. Amblard

Corium coolability after a severe PWR accident involving core meltdown and RPV failure is one of the main items in nuclear safety. The case considered here is a situation in which the corium is supposed to spread over a concrete floor and is flooded by water. In this frame, many researches are performed to study the physical phenomena which may enhance the heat transfer between the corium and the water pool. Among them, the melt entrainment above the corium crust by the sparging gas released by the concrete ablation appears as a potentially efficient cooling mechanism. The main target of the experimental program PERCOLA is to provide qualitative and quantitative information on this entrainment phenomenon. The first part of this paper is devoted to a general description of the experimental program and to the presentation of the main results. In a second part, the attention is focused on the modelling of the liquid entrainment phenomenon and to the comparison between the experimental data and the calculation results of two different entrainment models.


2001 ◽  
Vol 42 (2) ◽  
pp. 391-428 ◽  
Author(s):  
PATRICK PERETTI-WATEL

Car driving has received little attention from sociologists. Existing analyses highlight the irrationality of drivers, victims of an ‘illusion of control’, a ‘bias of optimism’ or influenced by social and cultural factors. Using qualitative and quantitative information, this article suggests a new perspective, in which driving is regarded as a ‘social activity’ (in the Weberian sense) and it is presumed that drivers operate on a cognitive rationality.


2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Matteo Sofia ◽  
Mauro Maniscalco ◽  
Guglielmo de Laurentiis ◽  
Debora Paris ◽  
Dominique Melck ◽  
...  

There is increasing evidence that biomarkers of exhaled gases or exhaled breath condensate (EBC) may help in detecting abnormalities in respiratory diseases mirroring increased, oxidative stress, airways inflammation and endothelial dysfunction. Beside the traditional techniques to investigate biomarker profiles, “omics” sciences have raised interest in the clinical field as potentially improving disease phenotyping. In particular, metabonomics appears to be an important tool to gain qualitative and quantitative information on low-molecular weight metabolites present in cells, tissues, and fluids. Here, we review the potential use of EBC as a suitable matrix for metabonomic studies using nuclear magnetic resonance (NMR) spectroscopy. By using this approach in airway diseases, it is now possible to separate specific EBC profiles, with implication in disease phenotyping and personalized therapy.


1990 ◽  
Vol 185 ◽  
Author(s):  
Carol A. Handwerker ◽  
Heather N. Lechtman ◽  
Ryna B. Marinenko ◽  
David S. Bright ◽  
Dale E. Newbury

AbstractPlatinum and platinum-gold metallurgy was fully developed by smiths in the Esmeraldas-Tumaco Pacific coast area of present day Ecuador and Colombia long before the arrival of Europeans in South America and centuries before platinum metallurgy became practicable in the Western world. Using gold to sinter together nuggets of native placer platinum, then alternately working and annealing the resultant solid, these South American smiths produced hard, fairly homogeneous platinum-gold alloys of a range of colors for fabrication into items of adornment, and small tools, such as needles, tweezers, awls, and fishhooks.The microstructures and compositions of sintered Pt-Au objects from La Tolita, Ecuador, and of experimentally simulated Pt-Au alloy samples were analyzed using new electron microprobe microanalysis (EPMA) techniques and data from the Pt-Au phase diagram in an effort to determine the fabrication temperatures used by Pre-Hispanic South American smiths. A comparison of EPMA results from the simulated materials with the corresponding results from the La Tolita Pt-Au objects suggests that the Pt-Au objects were never heated as high as 1100°C and probably never contained a liquid phase. As illustrated by this comparison, the qualitative and quantitative information provided by these new digital acquisition and display techniques far exceeds what conventional line scan and x-ray dot maps could provide.


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