scholarly journals A Novel Functional In Vitro Model that Recapitulates Human Muscle Disorders

2018 ◽  
Author(s):  
Iván Toral-Ojeda ◽  
Garazi Aldanondo ◽  
Jaione Lasa-Elgarresta ◽  
Haizpea Lasa-Fernandez ◽  
Camila Vesga-Castro ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Human Muscle ◽  
Muscle Disorders ◽  
Vitro Model

scholarly journals Effect of MAPK Inhibition on the Differentiation of a Rhabdomyosarcoma Cell Line Combined With CRISPR/Cas9 Technology: An In Vitro Model of Human Muscle Diseases

2018 ◽  
Vol 77 (10) ◽  
pp. 964-972 ◽  
Author(s):  
Noemí De Luna ◽  
Xavier Suarez-Calvet ◽  
Maialen Garicano ◽  
Esther Fernandez-Simon ◽  
Ricardo Rojas-García ◽  
...  
Keyword(s):  
Cell Line ◽  
In Vitro Model ◽  
Human Muscle ◽  
Muscle Diseases ◽  
Rhabdomyosarcoma Cell Line ◽  
Rhabdomyosarcoma Cell ◽  
Vitro Model

Modelling FUS Mislocalisation in an In Vitro Model of Innervated Human Muscle

2017 ◽  
Vol 62 (3-4) ◽  
pp. 318-328 ◽  
Author(s):  
Sonja Prpar Mihevc ◽  
Mojca Pavlin ◽  
Simona Darovic ◽  
Marko Živin ◽  
Matej Podbregar ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Human Muscle ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

A new in vitro model for pre-transplantation diagnosis of frozen/thawed human ovarian tissue

2011 ◽  
Vol 71 (05) ◽  
Author(s):  
M Salama ◽  
K Winkler ◽  
KF Murach ◽  
S Hofer ◽  
L Wildt ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Ovarian Tissue ◽  
Human Ovarian Tissue ◽  
Vitro Model
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