scholarly journals Multidisciplinary Approach of Malignant Tumors of the Biliary Tree

2018 ◽  
Author(s):  
Jesus Rodriguez-Pascual ◽  
Michael Tyler Babbitt ◽  
Enrique Sanz ◽  
Antonio Cubillo
Keyword(s):  
Multidisciplinary Approach ◽  
Malignant Tumors ◽  
Biliary Tree

scholarly journals Rheumatic Immune-Related Adverse Events—A Consequence of Immune Checkpoint Inhibitor Therapy

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 561
Author(s):  
Anca Bobircă ◽  
Florin Bobircă ◽  
Ioan Ancuta ◽  
Alesandra Florescu ◽  
Vlad Pădureanu ◽  
...  
Keyword(s):  
Immune System ◽  
Adverse Events ◽  
Immune Checkpoint ◽  
Multidisciplinary Approach ◽  
Malignant Tumors ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Cancer Cell Growth ◽  
Inhibitory Mechanisms ◽  
Checkpoint Inhibitor Therapy

The advent of immunotherapy has changed the management and therapeutic methods for a variety of malignant tumors in the last decade. Unlike traditional cytotoxic chemotherapy, which works by interfering with cancer cell growth via various pathways and stages of the cell cycle, cancer immunotherapy uses the immune system to reduce malignant cells’ ability to escape the immune system and combat cell proliferation. The widespread use of immune checkpoint inhibitors (ICIs) over the past 10 years has presented valuable information on the profiles of toxic adverse effects. The attenuation of T-lymphocyte inhibitory mechanisms by ICIs results in immune system hyperactivation, which, as expected, is associated with various adverse events defined by inflammation. These adverse events, known as immune-related adverse events (ir-AEs), may affect any type of tissue throughout the human body, which includes the digestive tract, endocrine glands, liver and skin, with reports of cardiovascular, pulmonary and rheumatic ir-AEs as well. The adverse events that arise from ICI therapy are both novel and unique compared to those of the conventional treatment options. Thus, they require a multidisciplinary approach and continuous updates on the diagnostic approach and management.

scholarly journals А сlinical case report of mediastinal teratoma in an adolescent patient with Klinefelter syndrome

2020 ◽  
Vol 19 (4) ◽  
pp. 143-149
Author(s):  
S. S. Saliyeva ◽  
R. Z. Boranbayeva ◽  
B. M. Zhumadullayev ◽  
K. E. Khairov ◽  
E. V. Krivenko ◽  
...  
Keyword(s):  
Clinical Case ◽  
Multidisciplinary Approach ◽  
Klinefelter Syndrome ◽  
Malignant Tumors ◽  
Complete Removal ◽  
Cell Tumor ◽  
Growing Teratoma Syndrome ◽  
Mediastinal Teratoma ◽  
Mature Type ◽  
Derivatives Of

Teratoma is a germ cell tumor, which consists of derivatives of three germ layers and has various malignant potentials – from benign mature forms to immature embryonic forms with a somatic type of malignancy. Even the mature type of teratoma is biologically unpredictable providing for an ability to grow locally with invasion. Necessity for complete removal of tumors, wherever they are located, is explained by the fact that there is a risk of a possible development of growing teratoma syndrome or transformation into malignant tumors. This article describes the clinical case of growing teratoma syndrome of mediastinal localization in a teenager with Klinefelter syndrome, also as an example of the multidisciplinary approach of pediatric oncologists, surgeons, radiotherapists and pathomorphologists in decision-making for optimal treatment. The patients' parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

scholarly journals Leiomyosarcoma of Prostate

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Abdeljalil Heddat ◽  
Younes Houry ◽  
Redouane Rabii
Keyword(s):  
Therapeutic Approach ◽  
Multidisciplinary Approach ◽  
Malignant Tumors ◽  
Survival Rates ◽  
Multicenter Trial ◽  
Advanced Stage ◽  
Rare Tumor ◽  
Actuarial Survival ◽  
Term Survival

Prostate leiomyosarcoma is an extremely rare and very aggressive neoplasm that represents less than 0.1% of primary malignant tumors of the prostate. We present a patient with primary leiomyosarcoma of  prostate and examine the cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this rare tumor. Median survival was estimated at 17 months (95% CI 20.7–43.7 months) and the actuarial survival rates at 1, 3 and 5 years were 68%, 34% and 26%, respectively. The only predictors of long-term survival were negative surgical margins and the absence of metastatic disease at presentation. A multidisciplinary approach is necessary for the proper management of this terrible entity. Surgery with or without chemotherapy seems to be the main therapeutic method for operable leimyosarcomas, but in general there is no consensus on the best therapeutic approach. Most cases are diagnosed at an advanced stage of the disease. A global multicenter trial is needed to find therapies that would improve the prognosis.

Iatrogenic Lesions of the Biliary Tree: The Role of a Multidisciplinary Approach

2021 ◽  
pp. 169-174
Author(s):  
Sergio Calamia ◽  
Duilio Pagano ◽  
Salvatore Gruttadauria
Keyword(s):  
Multidisciplinary Approach ◽  
Biliary Tree

scholarly journals A Multidisciplinary Approach to the Treatment of COVID-Associated Complications After Pancreatoduodenal Resection (Case Report)

2021 ◽  
Vol 10 (3) ◽  
pp. 469-476
Author(s):  
T. E. Kim ◽  
D. A. Lebedev ◽  
M. M. Magomedbekov ◽  
K. A. Nugumanova ◽  
S. S. Petrikov ◽  
...  
Keyword(s):  
Postoperative Period ◽  
Infection Prevention ◽  
Multidisciplinary Approach ◽  
Clinical Observation ◽  
Malignant Tumors ◽  
Pancreatic Head ◽  
Thromboembolic Complications ◽  
Distal Common Bile Duct ◽  
Coronavirus Infection ◽  
Extensive Surgery

We report a clinical case of treatment of a complicated postoperative course in a patient who underwent pancreatoduodenal resection associated with coronavirus infection. Prevention and treatment of such complications have been suggested.Pancreatoduodenal resection (PDR) is indicated for malignant tumors of the pancreatic head, duodenum or its large papilla, distal common bile duct, as well as in chronic pancreatitis with a predominant lesion of the pancreatic head with severe pain syndrome.The given clinical observation describes an example of treatment of a patient who developed a series of thromboembolic complications in the early stages after PDR performed for a neuroendocrine tumor of the pancreatic head. The oncology disease, extensive surgery such as PDR, and the postoperative period itself are risk factors for the development of various thromboembolic complications. According to the literature, the incidence of thromboembolic complications after PDR is 3–3.3%.The reason for the atypical course of the postoperative period when performing pancreatoduodenal resection in patients with tumor of the pancreas may be conditions that are not directly related to either the pathology of the pancreas or the features of the surgical intervention. When analyzing the patient’s condition, one should take into account the conditions of treatment. In such situations, proper detection of COVID-19 and adequate correction of therapy can fundamentally change the outcome of the disease.

Upper gastrointestinal cancers

2019 ◽  
pp. 351-364
Author(s):  
Anne Margrethe Phillips
Keyword(s):  
Gall Bladder ◽  
Metastatic Disease ◽  
Multidisciplinary Approach ◽  
Early Stage ◽  
Biliary Tree ◽  
Gastrointestinal Cancers ◽  
Nursing Management ◽  
Malignant Tumours ◽  
Management Of Dysphagia ◽  
Upper Gastrointestinal

This chapter examines the aetiology, diagnosis, and management of malignant tumours of the oesophagus, stomach, liver, pancreas, gall bladder, and biliary tree. Surgical, radiotherapy, and chemotherapy treatments are mentioned, in relation to both early-stage and metastatic disease. It highlights the multidisciplinary approach to these tumours. Nursing management of dysphagia and other complex nutritional issues is also covered.

Endocrine cancers

2015 ◽  
Author(s):  
Jim Cassidy ◽  
Donald Bissett ◽  
Roy A. J. Spence OBE ◽  
Miranda Payne ◽  
Gareth Morris-Stiff
Keyword(s):  
Small Intestine ◽  
Multidisciplinary Approach ◽  
Biliary Tree ◽  
Malignant Tumours ◽  
Diagnosis And Management

This chapter examines the aetiology, diagnosis, and management of malignant tumours of the oesophagus, stomach, and small intestine as well as those of the liver, pancreas, gallbladder and the biliary tree. It highlights the multidisciplinary approach to these tumours and illustrates the improved results now being seen through this approach.

Solid Tumors in the Neonatal Period

NeoReviews ◽  
2014 ◽  
Vol 15 (2) ◽  
pp. e56-e68
Author(s):  
Karen S. Fernández
Keyword(s):  
Solid Tumors ◽  
Multidisciplinary Approach ◽  
Neonatal Period ◽  
Malignant Tumors ◽  
Diagnostic Evaluation ◽  
Therapeutic Interventions ◽  
Benign Tumors ◽  
Newborn Period ◽  
General Overview

Solid tumors discovered at birth or during the first month after delivery are rare. Neonatal tumors are often benign. Malignant tumors in neonates represent only 2% of all malignancies in childhood. Some tumors that appear histologically malignant may show benign behavior, whereas apparently benign tumors may be fatal by virtue of their site of origin, which makes neonatal tumors one of the most difficult diagnostic and therapeutic challenges in the neonatal units. Planning the diagnostic evaluation and therapeutic interventions necessitates a multidisciplinary approach that involves the neonatology, radiology, surgery, pathology, hematology, and oncology services. Here we provide a general overview of the most common tumors seen in the newborn period.

scholarly journals Gastrointestinal Stromal Tumors (GISTs) and Extragastrointestinal Stromal Tumors (E-GISTs) - A Review

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Sunil Vitthalrao Jagtap
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumors ◽  
Multidisciplinary Approach ◽  
Malignant Tumors ◽  
Tumor Type ◽  
Stromal Tumors ◽  
Long Term Follow Up

GISTs (Gastrointestinal Stromal Tumors) are the most frequently encountered mesenchymal tumor of the gastrointestinal tract. Gastrointestinal stromal tumors have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). GISTs present 0.1%-3.0% of gastrointestinal malignant tumors. The goals in treating patients with GIST are to maximize the chance of cure, minimize recurrence. A multidisciplinary approach to patients with GISTs is necessary to optimize the timing of medical and surgical therapy as they have unpredictable behavior. Also long term follow up is essential for all patients, independent of their benign or malignant characteristics. This review highlight on clinical, diagnostic imaging, histopatholpgical, immunohistochemical ,new markers and management modalities for Gastrointestinal Stromal Tumors (GISTs) and Extragastrointestinal stromal tumors (E-GISTs).

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