scholarly journals S6 Kinase: A Compelling Prospect for Therapeutic Interventions

2019 ◽  
Author(s):  
Sheikh Tahir Majeed ◽  
Rabiya Majeed ◽  
Ghazia Shah ◽  
Khurshid I Andrabi
Keyword(s):  
Therapeutic Interventions ◽  
S6 Kinase ◽  
Kinase A

scholarly journals Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver

2009 ◽  
Vol 297 (2) ◽  
pp. E410-E415 ◽  
Author(s):  
Jamie I. Baum ◽  
Scot R. Kimball ◽  
Leonard S. Jefferson
Keyword(s):  
Protein Metabolism ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Perfused Rat Liver ◽  
S6 Kinase ◽  
Akt Phosphorylation ◽  
Ribosomal Protein S6 ◽  
Mtorc1 Signaling ◽  
Kinase A

The opposing actions of insulin and glucagon on hepatic carbohydrate metabolism are well documented. In contrast, relatively little is known about how the two hormones interact to regulate hepatic protein metabolism. Previously, we reported that glucagon in the absence of insulin represses signaling through the mammalian target of rapamycin complex 1 (mTORC1). In the present study, we sought to determine whether or not the action of one hormone would dominate over the other in the regulation of mTORC1 signaling. Livers were perfused in situ with medium containing either no added hormones (control), 10 nM insulin, 100 nM glucagon, or a combination of the hormones. Compared with control livers, insulin stimulated Akt phosphorylation and mTORC1 signaling, as assessed by increased phosphorylation of the mTORC1 targets eIF4E-binding protein (4E-BP)1 and ribosomal protein S6 kinase (S6K)1, and promoted assembly of the eIF4G·eIF4E complex. Glucagon alone had no effect on mTORC1 signaling but stimulated the activity of protein kinase A (PKA). In the presence of a combination of insulin and glucagon, Akt and TSC2 phosphorylation and PKA activity were all increased compared with controls. However, mTORC1 signaling was repressed compared with livers perfused with medium containing insulin alone, and this effect was associated with reduced assembly of the mTORC1·eIF3 complex. Overall, the results suggest that glucagon acts in a dominant manner to repress insulin-induced mTORC1 signaling, which is in contrast to previous studies showing a dominant action of insulin in the control of hepatic gluconeogenesis.

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

2007 ◽  
Vol 25 (4) ◽  
pp. 209-226 ◽  
Author(s):  
Katarzyna Jastrzebski ◽  
Katherine M. Hannan ◽  
Elissaveta B. Tchoubrieva ◽  
Ross D. Hannan ◽  
Richard B. Pearson
Keyword(s):  
Ribosomal Protein ◽  
Ribosome Biogenesis ◽  
S6 Kinase ◽  
Coordinate Regulation ◽  
Ribosomal Protein S6 ◽  
And Function ◽  
Kinase A ◽  
Ribosomal Protein S6 Kinase

scholarly journals p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Noufira Poomakkoth ◽  
Aya Issa ◽  
Nabeel Abdulrahman ◽  
Somaia Gamal Abdelaziz ◽  
Fatima Mraiche
Keyword(s):  
Lung Cancer ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
S6 Kinase ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase ◽  
Kinase A

Drosophila S6 Kinase: A Regulator of Cell Size

Science ◽  
1999 ◽  
Vol 285 (5436) ◽  
pp. 2126-2129 ◽  
Author(s):  
J. Montagne
Keyword(s):  
Cell Size ◽  
S6 Kinase ◽  
Kinase A
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