scholarly journals Mycobacterium tuberculosis: Macrophage Takeover and Modulation of Innate Effector Responses

2018 ◽  
Author(s):  
Khalid Hussain Bhat ◽  
Imtiyaz Yaseen
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Innate Effector

scholarly journals Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice

2021 ◽  
Author(s):  
Andrea C. Bohrer ◽  
Ehydel Castro ◽  
Zhidong Hu ◽  
Artur T.L. Queiroz ◽  
Claire E. Tocheny ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lung Tissue ◽  
Nonhuman Primate ◽  
Host Resistance ◽  
Protective Role ◽  
Genetic Models ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Effector Cells ◽  
Innate Effector

Host resistance to Mycobacterium tuberculosis infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. Influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, employing complementary genetic models of eosinophil deficiency, we demonstrate that, in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.

Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

2021 ◽  
Vol 218 (10) ◽  
Author(s):  
Andrea C. Bohrer ◽  
Ehydel Castro ◽  
Zhidong Hu ◽  
Artur T.L. Queiroz ◽  
Claire E. Tocheny ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lung Tissue ◽  
Nonhuman Primate ◽  
Host Resistance ◽  
Protective Role ◽  
Genetic Models ◽  
Lung Lesions ◽  
Effector Cells ◽  
Innate Effector ◽  
Bacterial Control

Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.

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