scholarly journals Quorum Sensing Inhibition and Anti-Biofilm Activity of Traditional Chinese Medicines

2018 ◽  
Author(s):  
Xihong Zhao ◽  
Fenghuan Zhao ◽  
Nanjing Zhong
Keyword(s):  
Quorum Sensing ◽  
Traditional Chinese Medicines ◽  
Quorum Sensing Inhibition ◽  
Chinese Medicines

Exploiting Quorum Sensing Inhibition for the Control of Pseudomonas aeruginosa and Acinetobacter baumannii Biofilms

2017 ◽  
Vol 17 (17) ◽  
pp. 1915-1927 ◽  
Author(s):  
Israel Castillo-Juarez ◽  
Luis Esau Lopez-Jacome ◽  
Gloria Soberon-Chavez ◽  
Maria Tomas ◽  
Jintae Lee ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Acinetobacter Baumannii ◽  
Quorum Sensing Inhibition

Quorum Sensing Inhibition by Phenothiazines and Related Compounds

2011 ◽  
Vol 8 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Zoltan Gabor Varga ◽  
Mira Agnes Szabo ◽  
Zsuzsanna Schelz ◽  
Erno Szegedi ◽  
Leonard Amaral ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Quorum Sensing Inhibition ◽  
Related Compounds

scholarly journals In Silico Molecular Docking and Interaction Analysis of Traditional Chinese Medicines Against SARS-CoV-2 Receptor

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110150
Author(s):  
Gang Li ◽  
Wei Zhou ◽  
Xiurong Zhao ◽  
Ying Xie
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Interaction Analysis ◽  
Herbal Remedies ◽  
Receptor Protein ◽  
Stable Complex ◽  
Traditional Chinese Medicines ◽  
Ligand Interaction ◽  
Chinese Medicines ◽  
In Silico Molecular Docking

The novel coronavirus, 2019-nCoV, has led to a major pandemic in 2020 and is responsible for more than 2.9 million officially recorded deaths worldwide. As well as synthetic anti-viral drugs, there is also a need to explore natural herbal remedies. The Traditional Chinese Medicines (TCMs) system has been used for thousands of years for the prevention, diagnosis, and treatment of several chronic diseases. In this paper, we performed an in silico molecular docking and interaction analysis of TCMs against SARS-CoV-2 receptor RNA-dependent RNA polymerase (RdRp). We obtained the 5 most effective plant compounds which had a better binding affinity towards the target receptor protein. These compounds areforsythoside A, rutin, ginkgolide C, icariside II, and nolinospiroside E. The top-ranked compound, based on docking score, was nolinospiroside, a glycoside found in Ophiopogon japonicas that has antioxidant properties. Protein-ligand interaction analysis discerned that nolinospiroside formed a strong bond between ARG 349 of the protein receptor and the carboxylate group of the ligand, forming a stable complex. Hence, nolinospiroside could be deployed as a lead compound against SARS-CoV-2 infection that can be further investigated for its potential benefits in curbing the viral infection.

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