scholarly journals Brain Gangliosides and Their Function as Natural Adaptogenes

2018 ◽  
Author(s):  
Natalia F. Avrova ◽  
Yulia A. Vlasova
Keyword(s):  
Brain Gangliosides

Influence of Brain Gangliosides on the Formation and Properties of Supported Lipid Bilayers for Binding Kinetics Studies

2018 ◽  
Author(s):  
Luke Jordan ◽  
Nathan Wittenberg
Keyword(s):  
Lipid Bilayers ◽  
Binding Kinetics ◽  
Supported Lipid Bilayers ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Supported Lipid Bilayer ◽  
Head Groups ◽  
Lipid Diffusion ◽  
Kinetics Of ◽  
Brain Gangliosides

This is a comprehensive study of the effects of the four major brain gangliosides (GM1, GD1b, GD1a, and GT1b) on the adsorption and rupture of phospholipid vesicles on SiO2 surfaces for the formation of supported lipid bilayer (SLB) membranes. Using quartz crystal microbalance with dissipation monitoring (QCM-D) we show that gangliosides GD1a and GT1b significantly slow the SLB formation process, whereas GM1 and GD1b have smaller effects. This is likely due to the net ganglioside charge as well as the positions of acidic sugar groups on ganglioside glycan head groups. Data is included that shows calcium can accelerate the formation of ganglioside-rich SLBs. Using fluorescence recovery after photobleaching (FRAP) we also show that the presence of gangliosides significantly reduces lipid diffusion coefficients in SLBs in a concentration-dependent manner. Finally, using QCM-D and GD1a-rich SLB membranes we measure the binding kinetics of an anti-GD1a antibody that has similarities to a monoclonal antibody that is a hallmark of a variant of Guillain-Barre syndrome.

Ganglioside syndrome, a new autoimmune neurologic disorder, experimentally induced with brain gangliosides

1976 ◽  
Vol 2 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Yoshitaka Nagai ◽  
Takashi Momoi ◽  
Masaki Saito ◽  
Eizo Mitsuzawa ◽  
Sugishi Ohtani
Keyword(s):  
Neurologic Disorder ◽  
Brain Gangliosides ◽  
Experimentally Induced

Hormonal effects on the development of rat brain gangliosides—I. Cortisol

1979 ◽  
Vol 28 (6) ◽  
pp. 881-895 ◽  
Author(s):  
Alan J. Horowitz ◽  
Saul M. Schanberg
Keyword(s):  
Rat Brain ◽  
Hormonal Effects ◽  
Brain Gangliosides

Chip-based nanoelectrospray mass spectrometry of brain gangliosides

2011 ◽  
Vol 1811 (9) ◽  
pp. 513-535 ◽  
Author(s):  
Corina Flangea ◽  
Alina Serb ◽  
Eugen Sisu ◽  
Alina D. Zamfir
Keyword(s):  
Mass Spectrometry ◽  
Brain Gangliosides

Brain Gangliosides and Neurological Mutants

1987 ◽  
pp. 391-407 ◽  
Author(s):  
Nicole A. Baumann ◽  
M. L. Harpin ◽  
A. Baron-Van Evercooren ◽  
M. Iwamori ◽  
Yves Maurin
Keyword(s):  
Brain Gangliosides

scholarly journals Preparation of Ganglioside GM1 by Supercritical CO2 Extraction and Immobilized Sialidase

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3732
Author(s):  
Li Ji ◽  
Zhonghui Qiao ◽  
Xin Zhang ◽  
Xiaolei Cheng ◽  
Weiyang Wang ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Supercritical Co2 ◽  
Brain Diseases ◽  
High Yield ◽  
Acetone Powder ◽  
Supercritical Co2 Extraction ◽  
Ganglioside Gm1 ◽  
Pig Brain ◽  
Optimum Extraction ◽  
Brain Gangliosides

Monosialotetrahexosylganglioside (GM1) has good activity on brain diseases and was developed to be a drug applied in clinics for neurological disorders and nerve injury. It is difficult to isolate GM1 in industry scale from the brains directly. In this work, a simple and highly efficient method with high yield was developed for the isolation, conversion, and purification of GM1 from a pig brain. Gangliosides (GLS) were first extracted by supercritical CO2 (SCE). The optimum extraction time of GLS by SCE was 4 h, and the ratio of entrainer to acetone powder from the pig brain was 3:1 (v/w). GM1 was then prepared from GLS by immobilized sialidase and purified by reverse-phase silica gel. Sodium alginate embedding was used for the immobilization of sialidase. Under the optimized method, the yield of high-purity GM1 was around 0.056%. This method has the potential to be applied in the production of GM1 in the industry.

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