scholarly journals The New Pharmacological Approaches for the Regulation of Functional Activity of G Protein-Coupled Receptors

2018 ◽  
Author(s):  
Alexander O. Shpakov ◽  
Kira Viktorovna Derkach
Keyword(s):  
G Protein ◽  
Functional Activity ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Controlling receptor function from the extracellular vestibule of G-protein coupled receptors

2020 ◽  
Vol 56 (91) ◽  
pp. 14167-14170
Author(s):  
Attila Egyed ◽  
Katalin Domány-Kovács ◽  
Bence Koványi ◽  
Ferenc Horti ◽  
Dalma Kurkó ◽  
...  
Keyword(s):  
G Protein ◽  
Functional Activity ◽  
Binding Pocket ◽  
G Protein Coupled Receptors ◽  
D3 Receptor ◽  
Receptor Function ◽  
Receptor Ligands ◽  
Dopamine D2 ◽  
G Protein Coupled

Here we show that the functional activity and signalling of dopamine D2 and D3 receptor ligands can be fine tuned from the extracellular secondary binding pocket (SBP) located far from the signalling interface.

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