scholarly journals Economic Evaluations in Health from the Perspective of the Costs Associated with Diabetes Mellitus Treatment

2018 ◽  
Author(s):  
Maurílio de Souza Cazarim ◽  
Ana Carolina de Oliveira Gonçalves ◽  
Leonardo Régis Leira Pereira ◽  
André de Oliveira Baldoni
Keyword(s):  
Diabetes Mellitus ◽  
Economic Evaluations ◽  
Diabetes Mellitus Treatment

Patient Perspectives on the Burden of Type 2 Diabetes Mellitus Treatment

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 726-P
Author(s):  
KRISTINA YU-ISENBERG ◽  
GEOF D. GRAY ◽  
CATHERINE FOLEY ◽  
JONATHAN T. STOKES ◽  
ALAN SHIELDS ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Patient Perspectives ◽  
Diabetes Mellitus Treatment

90-LB: Treatments and Trends in Glycemic Control for Patients with Type 2 Diabetes Mellitus Treatment following Metformin

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 90-LB
Author(s):  
SANJAY K. BAJPAI ◽  
RADHIKA NAIR ◽  
TICH CHANGAMIRE ◽  
RICHARD SHEER ◽  
QIANQIAN WANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetes Mellitus Treatment

SGLT2 Inhibitors in Diabetes Mellitus Treatment

2017 ◽  
Vol 12 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Juan Rosas-Guzman ◽  
Juan Rosas-Saucedo ◽  
Alma Romero-Garcia
Keyword(s):  
Diabetes Mellitus ◽  
Sglt2 Inhibitors ◽  
Diabetes Mellitus Treatment

scholarly journals Three-Year Outcomes of Bariatric Surgery vs Lifestyle Intervention for Type 2 Diabetes Mellitus Treatment

JAMA Surgery ◽  
2015 ◽  
Vol 150 (10) ◽  
pp. 931 ◽  
Author(s):  
Anita P. Courcoulas ◽  
Steven H. Belle ◽  
Rebecca H. Neiberg ◽  
Sheila K. Pierson ◽  
Jessie K Eagleton ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Type 2 Diabetes Mellitus ◽  
Lifestyle Intervention ◽  
Diabetes Mellitus Treatment

Insulin therapy for diabetes mellitus: Treatment regimens and associated costs

2012 ◽  
Vol 38 (2) ◽  
pp. 156-163 ◽  
Author(s):  
B. Charbonnel ◽  
A. Penfornis ◽  
M. Varroud-Vial ◽  
O. Kusnik-Joinville ◽  
B. Detournay
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Therapy ◽  
Treatment Regimens ◽  
Diabetes Mellitus Treatment

scholarly journals Factors Associated with Type 2 Diabetes Mellitus Treatment Choice Across Four European Countries

2017 ◽  
Vol 39 (11) ◽  
pp. 2296-2310.e14 ◽  
Author(s):  
Edith M. Heintjes ◽  
Jetty A. Overbeek ◽  
Gillian C. Hall ◽  
Daniel Prieto-Alhambra ◽  
Francesco Lapi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Choice ◽  
European Countries ◽  
Factors Associated ◽  
Diabetes Mellitus Treatment

scholarly journals The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Natural Products ◽  
Promising Therapeutic Target ◽  
Prevalent Disease ◽  
Bibliographic Search ◽  
Treatment Of Diabetes ◽  
Definition Of ◽  
Diabetes Mellitus Treatment

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.

scholarly journals Exosome-Mediated Insulin Delivery for the Potential Treatment of Diabetes Mellitus

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1870
Author(s):  
Belén Rodríguez-Morales ◽  
Marilena Antunes-Ricardo ◽  
José González-Valdez
Keyword(s):  
Diabetes Mellitus ◽  
Human Insulin ◽  
Insulin Delivery ◽  
Dermal Fibroblasts ◽  
Therapeutic Drug ◽  
Extracellular Medium ◽  
Glucose Levels ◽  
Wide Range ◽  
Diabetes Mellitus Treatment

Exosomes are extracellular nanovesicles between 30 and 150 nm that serve as essential messengers for different biological signaling and pathological processes. After their discovery, a wide range of applications have been developed, especially in therapeutic drug delivery. In this context, the aim of this work was to test the efficiency of exosome-mediated human insulin delivery using exosomes extracted from three different cell lines: hepatocellular carcinoma (HepG2); primary dermal fibroblasts (HDFa) and pancreatic β cells (RIN-m); all are related to the production and/or the ability to sense insulin and to consequently regulate glucose levels in the extracellular medium. The obtained results revealed that the optimal insulin loading efficiency was achieved by a 200 V electroporation, in comparison with incubation at room temperature. Moreover, the maximum in vitro exosome uptake was reached after incubation for 6 h, which slightly decreased 24 h after adding the exosomes. Glucose quantification assays revealed that exosome-mediated incorporation of insulin presented significant differences in HDFa and HepG2 cells, enhancing the transport in HDFa, in comparison with free human insulin effects in the regulation of extracellular glucose levels. No significant differences were found between the treatments in RIN-m cells. Hence, the results suggest that exosomes could potentially become a valuable tool for stable and biocompatible insulin delivery in diabetes mellitus treatment alternatives.

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