scholarly journals Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease

2018 ◽  
Author(s):  
Ozkan Ozden ◽  
Kevser Tural
Keyword(s):  
Cancer Cells ◽  
Cardiovascular Health ◽  
Sirtuin 3 ◽  
Health And Disease

scholarly journals Exploring the Role of Endothelial Cell Resilience in Cardiovascular Health and Disease

2020 ◽  
Author(s):  
Yunling Gao ◽  
Zorina S. Galis
Keyword(s):  
Risk Factors ◽  
Paradigm Shift ◽  
Cardiovascular Health ◽  
Research Effort ◽  
Future Research ◽  
Therapeutic Approaches ◽  
New Knowledge ◽  
Health And Disease ◽  
Disease Understanding

Traditionally, much research effort has been invested into focusing on disease, understanding pathogenic mechanisms, identifying risk factors, and developing effective treatments. A few recent studies unraveling the basis for absence of disease, including cardiovascular disease, despite existing risk factors, a phenomenon commonly known as resilience, are adding new knowledge and suggesting novel therapeutic approaches. Given the central role of endothelial function in cardiovascular health, we herein provide a number of considerations that warrant future research and considering a paradigm shift toward identifying the molecular underpinnings of endothelial resilience.

scholarly journals Pivotal role of α2 Na+pumps and their high affinity ouabain binding site in cardiovascular health and disease

2016 ◽  
Vol 594 (21) ◽  
pp. 6079-6103 ◽  
Author(s):  
Mordecai P. Blaustein ◽  
Ling Chen ◽  
John M. Hamlyn ◽  
Frans H. H. Leenen ◽  
Jerry B. Lingrel ◽  
...  
Keyword(s):  
Binding Site ◽  
Cardiovascular Health ◽  
Pivotal Role ◽  
Ouabain Binding ◽  
High Affinity ◽  
Health And Disease

scholarly journals Restoring of miR-193a-5p Sensitizes Breast Cancer Cells to Paclitaxel through P53 Pathway

2020 ◽  
Vol 10 (4) ◽  
pp. 595-601 ◽  
Author(s):  
Monireh Khordadmehr ◽  
Roya Shahbazi ◽  
Behzad Baradaran ◽  
Sanam Sadreddini ◽  
Dariush Shanebandi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Expression Level ◽  
Dapi Staining ◽  
Scratch Wound ◽  
Effective Therapeutic Strategy ◽  
Health And Disease ◽  
And Migration ◽  
Induced Apoptosis

Purpose : Recent evidence presented the important role of microRNAs in health and disease particularly in human cancers. Among those, miR-193 family contributes as a tumor suppressor in different benign and malignant cancers like breast cancer (BC) via interaction with specific targets. On the other hand, it was stated that miR-193 is able to modulate some targets in chemoresistant cancer cells. Therefore, the aim of this study was to evaluate the potential function of miR-193a-5p and paclitaxel in the apoptosis induction by targeting P53 in BC cells. Methods: At first, miR-193a-5p mimics were transfected to MDA-MB-231 BC cell line which indicated the lower expression level of miR-193a-5p. Subsequently, the transfected cells were treated with paclitaxel. Then, cell viability, apoptosis, and migration were evaluated by MTT, flow cytometry and DAPI staining, and scratch-wound motility assays, respectively. Moreover, the expression levels of P53 was evaluated by qRT-PCR. Results: The expression level of miR-193a-5p was restored in MDA-MB-231 cells which profoundly inhibited the proliferation (P<0.0001), induced apoptosis (P<0.0001) and harnessed migration (P<0.0001) in the BC cells and more effectiveness was observed in combination with paclitaxel. Interestingly, increased miR-193a-5p expression led to a reduction in P53 mRNA, offering that it can be a potential target of miR-193a. Conclusion: Taken together, it is concluded that the combination of miR-193a-5p restoration and paclitaxel could be potentially considered as an effective therapeutic strategy to get over chemoresistance during paclitaxel chemotherapy

The endoplasmic reticulum in cardiovascular health and disease

2012 ◽  
Vol 90 (9) ◽  
pp. 1209-1217 ◽  
Author(s):  
Robyn Millott ◽  
Elzbieta Dudek ◽  
Marek Michalak
Keyword(s):  
Cardiovascular Disease ◽  
Endoplasmic Reticulum ◽  
Cardiovascular Health ◽  
Integral Membrane Protein ◽  
Renal Diseases ◽  
Adaptive Responses ◽  
Progression Of Disease ◽  
Health And Disease ◽  
Set Up

The endoplasmic reticulum has an intricate network of pathways built to deal with the secretory and integral membrane protein synthesis demands of the cell, as well as adaptive responses set up for the endoplasmic reticulum to rely on when stressed. These pathways are both essential and complex, and because of these 2 factors, several situations can lead to a dysfunctional endoplasmic reticulum and result in a dysfunctional cell with the potential to contribute to the progression of disease. The endoplasmic reticulum has been implicated in several metabolic, neurodegenerative, inflammatory, autoimmune, and renal diseases and disorders, and in particular, cardiovascular diseases. The role of the endoplasmic reticulum in cardiovascular disease shows how the change in function of a particular microscopic organelle can lead to macroscopic changes in the form of disease.

scholarly journals The role of adipose tissue in cardiovascular health and disease

2018 ◽  
Vol 16 (2) ◽  
pp. 83-99 ◽  
Author(s):  
Evangelos K. Oikonomou ◽  
Charalambos Antoniades
Keyword(s):  
Adipose Tissue ◽  
Cardiovascular Health ◽  
Health And Disease

scholarly journals Tearin' Up My Heart: Proteolysis in the Cardiac Sarcomere

2011 ◽  
Vol 286 (12) ◽  
pp. 9929-9934 ◽  
Author(s):  
Andrea L. Portbury ◽  
Monte S. Willis ◽  
Cam Patterson
Keyword(s):  
Cardiovascular Health ◽  
Ubiquitin Proteasome System ◽  
Structure And Function ◽  
Cardiac Sarcomere ◽  
Ubiquitin Proteasome ◽  
Health And Disease ◽  
The Individual ◽  
And Function ◽  
Calpain System

Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three major pathways of proteolysis have been identified as being active within the cardiac sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain system. The role of ubiquitin-proteasome system-mediated proteolysis in cardiovascular health and disease has been known for some time; however, it is now apparent that other proteolytic systems also aid in the stabilization of cardiac sarcomere structure and function. This minireview focuses on the individual as well as cooperative involvement of each of these three major pathways of proteolysis within the cardiac sarcomere.

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