scholarly journals Polymeric Scaffolds for Bioartificial Cardiovascular Prostheses

2017 ◽  
Author(s):  
Marcel Ricklefs ◽  
Sotiris Korossis ◽  
Axel Haverich ◽  
Tobias Schilling
Keyword(s):  
Polymeric Scaffolds

The optimization of porous polymeric scaffolds for chondrocyte/atelocollagen based tissue-engineered cartilage

Biomaterials ◽  
2010 ◽  
Vol 31 (16) ◽  
pp. 4506-4516 ◽  
Author(s):  
Yoko Tanaka ◽  
Hisayo Yamaoka ◽  
Satoru Nishizawa ◽  
Satoru Nagata ◽  
Toru Ogasawara ◽  
...  
Keyword(s):  
Polymeric Scaffolds ◽  
Engineered Cartilage

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

2021 ◽  
Vol 17 (1) ◽  
pp. 015003
Author(s):  
Lya Piaia ◽  
Simone S Silva ◽  
Joana M Gomes ◽  
Albina R Franco ◽  
Emanuel M Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Cellular Proliferation ◽  
Mechanical Performance ◽  
Tissue Growth ◽  
Polymeric Scaffolds ◽  
Bioactive Agents

Abstract Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable materials for bone regeneration solutions. The present work aimed to create chitosan/beta-tricalcium phosphate-based scaffolds coated with silk fibroin and evaluate their potential for bone tissue engineering. Results showed that the obtained scaffolds have porosities up to 86%, interconnectivity up to 96%, pore sizes in the range of 60–170 μm, and a stiffness ranging from 1 to 2 MPa. Furthermore, when cultured with MC3T3 cells, the scaffolds were able to form apatite crystals after 21 d; and they were able to support cell growth and proliferation up to 14 d of culture. Besides, cellular proliferation was higher on the scaffolds coated with silk. These outcomes further demonstrate that the developed structures are suitable candidates to enhance bone tissue engineering.

Fabrication of porous polymeric structures using a simple sonication technique for tissue engineering

2017 ◽  
Vol 37 (9) ◽  
pp. 943-951 ◽  
Author(s):  
Alan Saúl Álvarez-Suarez ◽  
Eduardo Alberto López-Maldonado ◽  
Olivia A. Graeve ◽  
Fabián Martinez-Pallares ◽  
Luis Enrique Gómez-Pineda ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Poly Vinyl Alcohol ◽  
Porous Structures ◽  
Average Pore ◽  
Ultrasonic Probe ◽  
Polymeric Scaffolds ◽  
Before And After ◽  
Water Absorption Test ◽  
Sonication Technique ◽  
Polymeric Structures

AbstractPorous polymeric scaffolds have been applied successfully in the biomedical field. This work explores the use of an ultrasonic probe to generate cavitation in a polymeric solution, thus producing pores in the polymeric scaffolds. Porous polymeric structures with average pore sizes ranging from 5 to 63 μm and porosity of 6–44% were fabricated by a process consisting of sonication, flash freezing, and lyophilization of poly(lactic-co-glycolic acid) (PLGA), gelatin (GEL), chitosan (CS) and poly(vinyl alcohol) (PVAL) solutions. Pore structure was characterized by scanning electron microscopy (SEM) and image analysis software. The infrared spectra were analyzed before and after the fabrication process to observe any change in the chemical structure of the polymers. A water absorption test indicated the susceptibility of the samples to retain water in their structure. TGA results showed that GEL experienced degradation at 225°C, CS had a decomposition peak at 280°C, the thermal decomposition of PLGA occurred at 375°C, and PVAL showed two degradation regions. The DSC analysis showed that the glass transition temperature (Tg) of GEL, CS, PLGA and PVAL occurred at 70°C, 80°C, 60°C and 70°C, respectively. The fabricated porous structures demonstrated similar physical characteristics to those found in bone and cartilage.

Nanostructuring of PEG–fibrinogen polymeric scaffolds

2010 ◽  
Vol 6 (7) ◽  
pp. 2518-2524 ◽  
Author(s):  
Ilya Frisman ◽  
Dror Seliktar ◽  
Havazelet Bianco-Peled
Keyword(s):  
Polymeric Scaffolds

Polymeric scaffolds as stem cell carriers in bone repair

2013 ◽  
Vol 9 (10) ◽  
pp. 1093-1119 ◽  
Author(s):  
Filippo Rossi ◽  
Marco Santoro ◽  
Giuseppe Perale
Keyword(s):  
Stem Cell ◽  
Bone Repair ◽  
Polymeric Scaffolds ◽  
Cell Carriers

Polymeric Scaffolds for Regenerative Medicine

2009 ◽  
pp. 467-495
Author(s):  
Paul De Bank ◽  
Matthew Jones ◽  
Marianne Ellis
Keyword(s):  
Regenerative Medicine ◽  
Polymeric Scaffolds

scholarly journals Polyvalent transition-state analogues of sialyl substrates strongly inhibit bacterial sialidases.

2020 ◽  
Author(s):  
coralie assailly ◽  
clarisse bridot ◽  
amélie saumonneau ◽  
paul lottin ◽  
Benoit Roubinet ◽  
...  
Keyword(s):  
Transition State ◽  
Important Class ◽  
Inhibitory Potency ◽  
Polymeric Scaffolds ◽  
Transition State Analogues

<div>Conjugation of the transitionstate-cation analogue DANA to polymeric scaffolds led to highly potent inhibitors of bacterial sialidases. Each clustered DANA on the polymers saw its inhibitory potency for S. pneumoniae or B. thetaiotaomicron sialidases improved by more than four orders of magnitude. This extends the multivalent concept to this important class of enzymes.</div><div><br></div>

Glycerol-Mediated Nanostructure Modification Leading to Improved Transparency of Porous Polymeric Scaffolds for High Performance 3D Cell Imaging

2014 ◽  
Vol 15 (7) ◽  
pp. 2521-2531 ◽  
Author(s):  
Shan Zhao ◽  
Zhiyuan Shen ◽  
Jingyu Wang ◽  
Xiaokang Li ◽  
Yang Zeng ◽  
...  
Keyword(s):  
High Performance ◽  
Cell Imaging ◽  
Polymeric Scaffolds
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