scholarly journals Antidiabetic and Safety Properties of Ethanolic Leaf Extract of Corchorus olitorius in Alloxan-Induced Diabetic Rats

2018 ◽  
Author(s):  
Arise Rotimi Olusanya ◽  
Bankole S. Ifeoluwa ◽  
Aboyewa Jumoke A. ◽  
Bobbo Khadijat
Keyword(s):  
Leaf Extract ◽  
Diabetic Rats ◽  
Corchorus Olitorius ◽  
Safety Properties ◽  
Ethanolic Leaf Extract

scholarly journals EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT EFFECTS OF ETHANOLIC LEAF EXTRACT OF ERYTHRINA ABBYSINICA LAM, EX DC

2018 ◽  
Vol 11 (8) ◽  
pp. 300
Author(s):  
Kamadyaapa Davie Rexon ◽  
Gondwe Mavuto Masopera ◽  
Shauli Mathulo ◽  
Sewani Rusike Constance ◽  
Nkeh Chungag Benedicta
Keyword(s):  
Blood Glucose ◽  
Leaf Extract ◽  
Antioxidant Properties ◽  
Diabetic Rats ◽  
Control Group ◽  
Oral Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Ethanolic Leaf Extract ◽  
Antioxidant Effects

  Objective: This study was conducted to scientifically evaluate the antidiabetic and antioxidant effects of ethanolic leaf extract of Erythrina abbysinica (EEA).Methods: Acute and sub-chronic effects of EEA at 100, 200, and 400 mg/kg/bwt and glibenclamide (GL) at 5 mg/kg/bwt. were evaluated in both normal and streptozotocin (STZ)-induced diabetic male Wistar rats (250–300 g). The acute studies were performed using oral glucose tolerance test (OGTT). In sub-chronic studies, animals were orally administered with EEA and GL daily for 6 w. Brine shrimp assay was used to determine the toxicity of EEA. 1, 1-diphenyl-2-picrylhydrazyl, ferric reducing capacity of plasma, and thiobarbituric acid reactive substances assays were used to determine antioxidant properties of EEA.Results: Following OGTT, EEA significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in both normal and STZ-induced diabetic rats when compared with positive and negative control counterparts at all-time points, whereas GL significantly (p<0.05) decreased blood glucose only in normal rats but not in diabetic rats. Daily, oral administration of EEA for 6 w significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in STZ-induced diabetic rats when compared with the diabetic control group. EEA revealed weak toxicity with a lethal concentration50 value of 997 μg/ml). Furthermore, EEA showed significant free radical scavenging, total antioxidant, and anti-lipid peroxidative capacities.Conclusion: The study has shed more light on the scientific basis for the use of E. abbysinica in management of diabetes in some communities of Eastern Cape of South Africa.

scholarly journals ANNONA MURICATA LINN. ETHANOLIC LEAF EXTRACT AMELIORATES REPRODUCTIVE COMPLICATIONS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

2020 ◽  
Vol 18 (1) ◽  
pp. 166-175
Author(s):  
O. E. ADELEYE ◽  
N. A. ABOAJAH ◽  
A. I. ADELEYE ◽  
E. A.O. SOGEBI ◽  
F. M. MSHELBWALA ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Sperm Count ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Male Rats ◽  
Annona Muricata ◽  
Major Health Problem ◽  
Ethanolic Leaf Extract

Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annona muricata ethanolic leaf extract (AMELE) on fertility of male diabetic rats and levels of blood glucose. Twenty male Wistar rats (150-200g) were randomly distributed into 4 groups (n=5) treated thus: CTRL (control), DNT, DT1 and DT2 (diabetic, single intraperitoneal injection, streptozotocin, 60 mg/kg). Group DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks via thiopental injection and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. The results showed that oral administration of AMELE at 100 mg/kg and 200 mg/kg to diabetic male rats for fourteen days significantly decreased blood glucose level and also ameliorated diabetes-induced decreases in sperm functions in streptozotocin-induced diabetic male rats.    

scholarly journals Effect of ethanolic leaf extract of Vinca major L. on biochemical parameters and glucose level of alloxan induced diabetic rats

2019 ◽  
Vol 18 (32) ◽  
pp. 1054-1068 ◽  
Author(s):  
Comfort Monago-Ighorodje ◽  
Majesty Duru ◽  
Eze Adindu ◽  
Kelechi Nwauche ◽  
Ahamefula Ezekwe ◽  
...  
Keyword(s):  
Glucose Level ◽  
Biochemical Parameters ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Vinca Major ◽  
Ethanolic Leaf Extract

scholarly journals Lipid profile status of streptozotocin induced diabetic rats treated with ethanolic leaf extract of Solenostemon monostachyus

2015 ◽  
Vol 9 (8) ◽  
pp. 289-293 ◽  
Author(s):  
Amaechi Dennis ◽  
O. Udosen E. ◽  
E. Edet E. ◽  
E. Asanga E. ◽  
E. Mbakwe I.
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Ethanolic Leaf Extract
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