scholarly journals Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

2018 ◽  
Author(s):  
Lawrence Madikizela ◽  
Nikita Tavengwa ◽  
Vusumzi Pakade
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Pharmaceutical Compounds ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Analytical Applications

scholarly journals Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers

Polymers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 974 ◽  
Author(s):  
In-Hyuk Baek ◽  
Hyung-Seop Han ◽  
Seungyun Baik ◽  
Volkhard Helms ◽  
Youngjun Kim
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Quartz Crystal ◽  
Pharmaceutical Compounds ◽  
Binding Activity ◽  
Significant Loss ◽  
Chemical Probes ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Chemical Pollutant

Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a chemical pollutant. Adsorption and quartz crystal microbalance with dissipation monitoring experiments showed that the phage-functionalized MIP had a good binding affinity for CA, compared with the non-imprinted polymer and MIP. In addition, the reusability of the phage-functionalized MIP was demonstrated for at least five repeated cycles, without significant loss in the binding activity. The results indicate that the exposed amino acids of the phage, together with the polymer matrix, create functional binding cavities that provide higher affinity to acidic pharmaceutical compounds.

Preparation of Benzonic Acid Molecularly Imprinted Polymers and Its Adsorption Property

2010 ◽  
Vol 38 (3) ◽  
pp. 401-404
Author(s):  
Da-Wei LOU ◽  
Ying-Jie YANG ◽  
Guang HUANG ◽  
Ping-Li PU ◽  
Xin-Qing LEE ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Adsorption Property ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Adsorption Capacity and Selectivity of Molecularly Imprinted Polymers towards β-Sitosterol

2019 ◽  
Vol 31 (11) ◽  
pp. 2527-2531
Author(s):  
St. Fauziah ◽  
N.H. Soekamto ◽  
P. Budi ◽  
P. Taba
Keyword(s):  
Adsorption Capacity ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Polymerization Reaction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Sample Extract ◽  
Uv Visible ◽  
Adsorption Desorption ◽  
Isothermal Equation

Molecularly imprinted polymers (MIP) as an adsorbent has been synthesized using β-sitosterol as molecule template on free radical polymerization reaction. The capacity and selectivity of the adsorption from MIP to β-sitosterol was studied in this study. The β-sitosterol concentration in the adsorption-desorption test and the MIP selectivity test were analyzed by UV-visible and HPLC. The MIP obtained from the synthesis results in a high adsorption capacity. Based on the Freundlich adsorption isothermal equation, the adsorption capacity (k) was found to be 1.24 mg/g. The MIP can adsorb 100 % β-sitosterol while cholesterol was only 3 %. The MIP is most selective to β-sitosterol, therefore, has high potential to apply as adsorbent at solid phase extraction method to isolate β-sitosterol from sample extract.

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