scholarly journals Animal Model of Parkinson Disease: Neuroinflammation and Apoptosis in the 6-Hydroxydopamine-Induced Model

2018 ◽  
Author(s):  
Daniel Hernandez-Baltazar ◽  
Rasajna Nadella ◽  
Maria de Jesus Rovirosa-Hernandez ◽  
Laura Mireya Zavala-Flores ◽  
Christian de Jesus Rosas Jarquin
Keyword(s):  
Animal Model ◽  
Parkinson Disease ◽  
6 Hydroxydopamine

A radiotracer method for the measurement of central nervous system catecholamines in vivo

1978 ◽  
Vol 56 (3) ◽  
pp. 535-538 ◽  
Author(s):  
S. W. Tang ◽  
H. C. Stancer ◽  
J. J. Warsh
Keyword(s):  
Central Nervous System ◽  
Animal Model ◽  
Nervous System ◽  
Specific Activity ◽  
Brain Catecholamines ◽  
Radiotracer Method ◽  
New Strategy ◽  
The Central Nervous System ◽  
6 Hydroxydopamine

A new strategy for measurement of brain catecholamines was tested in an animal model. [3H]Norepinephrine was infused intravenously in rabbits to label the peripheral norepinephrine pools. The specific activity of urinary 3-methoxy-4-hydroxymandelic acid was consistently higher than that for 3-methoxy-4-hydroxyphenylglycol (MHPG). Central sympathectomy with 6-hydroxydopamine abolished this difference. Using the formula we propose, it is estimated that 30–50% of urinary MHPG originates from the central nervous system.

scholarly journals Effect of Hydroalcoholic Extract of Ferulago angulata (Schlecht) Boiss on Motor and Memory Disorders in Animal Model of Parkinson Disease

2018 ◽  
Vol 12 (8) ◽  
pp. 36-47
Author(s):  
Razieh Mahmoudi ◽  
Maryam Rafieirad ◽  
Samira Goudarzi ◽  
◽  
◽  
...  
Keyword(s):  
Animal Model ◽  
Parkinson Disease ◽  
Memory Disorders ◽  
Hydroalcoholic Extract

Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia

2021 ◽  
Author(s):  
Ana E. Speck ◽  
Aderbal S. Aguiar ◽  
Samira G. Ferreira ◽  
Henrique B. Silva ◽  
Angelo R. Tomé ◽  
...  
Keyword(s):  
Animal Model ◽  
Physical Exercise ◽  
Long Term Potentiation ◽  
Moderate Intensity ◽  
Murine Models ◽  
Long Term Depression ◽  
Term Potentiation ◽  
Corticostriatal Plasticity ◽  
6 Hydroxydopamine

Physical exercise attenuates the development of L-DOPA-induced dyskinesia (LID) in 6-hydroxydopamine-induced hemiparkinsonian mice through unknown mechanisms. We now tested if exercise normalizes the aberrant corticostriatal neuroplasticity associated with experimental murine models of LID. C57BL/6 mice received two unilateral intrastriatal injections of 6-hydroxydopamine (12 μg) and were treated after three weeks with L-DOPA/benserazide (25/12.5 mg/kg) for four weeks, with individualized moderate-intensity running (60-70% V̇O2peak) or not (untrained). L-DOPA converted the pattern of plasticity in corticostriatal synapses from a long-term depression (LTD) into a long-term potentiation (LTP). Exercise reduced LID severity and decreased aberrant LTP. These results suggest that exercise attenuates abnormal corticostriatal plasticity to decrease LID.

scholarly journals Effects of Hypericum perforatum on turning behavior in an animal model of Parkinson's disease

2015 ◽  
Vol 51 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Débora Dalla Vecchia ◽  
Marissa Giovanna Schamne ◽  
Marcelo Machado Ferro ◽  
Ana Flávia Chaves dos Santos ◽  
Camila Lupepsa Latyki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Hypericum Perforatum ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Turning Behavior ◽  
Age Related ◽  
Lesion Side ◽  
6 Hydroxydopamine

Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-inflammatory properties. We evaluated the effects of H. perforatum on the turning behavior of rats submitted to a unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle as an animal model of PD. The animals were treated with H. perforatum (100, 200, or 400 mg/kg, v.o.) for 35 consecutive days (from the 28th day before surgery to the 7th day after). The turning behavior was evaluated at 7, 14 and 21 days after the surgery, and the turnings were counted as contralateral or ipsilateral to the lesion side. All tested doses significantly reduced the number of contralateral turns in all days of evaluation, suggesting a neuroprotective effect. However, they were not able to prevent the 6-OHDA-induced decrease of tyrosine hydroxylase expression in the lesioned striatum. We propose that H. perforatum may counteract the overexpression of dopamine receptors on the lesioned striatum as a possible mechanism for this effect. The present findings provide new evidence that H. perforatum may represent a promising therapeutic tool for PD.

scholarly journals Rho Kinase Inhibition by Fasudil in the Striatal 6-Hydroxydopamine Lesion Mouse Model of Parkinson Disease

2014 ◽  
Vol 73 (8) ◽  
pp. 770-779 ◽  
Author(s):  
Lars Tatenhorst ◽  
Lars Tönges ◽  
Kim-Ann Saal ◽  
Jan C. Koch ◽  
Éva M. Szegő ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
Rho Kinase ◽  
Kinase Inhibition ◽  
6 Hydroxydopamine

scholarly journals Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Hassan Dakik ◽  
Sarah Mantash ◽  
Ali Nehme ◽  
Firas Kobeissy ◽  
Masoud Zabet-Moghaddam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Systems Biology ◽  
Mouse Model ◽  
Cell Therapy ◽  
Parkinson Disease ◽  
Large Scale ◽  
Brain Regions ◽  
Nigrostriatal Pathway ◽  
Reconstruction Process

Advances in large-scale proteomics analysis have been very useful in understanding pathogenesis of diseases and elaborating therapeutic strategies. Proteomics has been employed to study Parkinson disease (PD); however, sparse studies reported proteome investigation after cell therapy approaches. In this study, we used liquid chromatography–tandem mass spectrometry and systems biology to identify differentially expressed proteins in a translational mouse model of PD after cell therapy. Proteins were extracted from five nigrostriatal-related brain regions of mice previously lesioned with 6-hydroxydopamine in the substantia nigra. Protein expression was compared in non-grafted brain to 1 and 7 days after intranigral grafting of E12.5 embryonic ventral mesencephalon (VM). We found a total of 277 deregulated proteins after transplantation, which are enriched for lipid metabolism, oxidative phosphorylation and PD, thus confirming that our animal model is similar to human PD and that the presence of grafted cells modulates the expression of these proteins. Notably, seven proteins (Acta1, Atp6v1e1, Eci3, Lypla2, Pip4k2a, Sccpdh, and Sh3gl2) were commonly down-regulated after engraftment in all studied brain regions. These proteins are known to be involved in the formation of lipids and recycling of dopamine (DA) vesicle at the synapse. Moreover, intranigral transplantation of VM cells decreased the expression of proteins related to oxidative stress, especially in the nigrostriatal pathway containing the DA grafted neurons. In the same regions, an up-regulation of several proteins including α-synuclein and tyrosine hydroxylase was observed, whereas expression of tetraspanin 7 was shut down. Overall, these results suggest that intranigral transplantation of VM tissue in an animal model of PD may induce a decrease of oxidative stress in the nigrostriatal pathway and a restoration of the machinery of neurotransmitters, particularly DA release to promote DA transmission through a decrease of D2 DA receptors endocytosis. Identification of new mechanistic elements involved in the nigrostriatal reconstruction process, using translational animal models and systems biology, is a promising approach to enhance the repair of this pathway in PD patients undergoing cell therapy.

activation of microglia lead to onset of Parkinson disease-like animal model

2010 ◽  
Vol 68 ◽  
pp. e192
Author(s):  
Atsuko Ishii ◽  
Sachiko Tanaka ◽  
Hirokazu Ohtaki ◽  
Seiji Shioda ◽  
Satoshi Numazawa ◽  
...  
Keyword(s):  
Animal Model ◽  
Parkinson Disease
Sign in / Sign up

Export Citation Format

Share Document