scholarly journals Small Non-Coding RNAs in Regulation of Course and Therapeutic Efficacy in Acute Myeloid Leukemia

2018 ◽  
Author(s):  
Oxana V. Klimenko
Keyword(s):  
Acute Myeloid Leukemia ◽  
Therapeutic Efficacy ◽  
Myeloid Leukemia ◽  
Non Coding Rnas ◽  
Acute Myeloid

Lipid Nanosystems Enhance the Bioavailability and the Therapeutic Efficacy of FTY720 in Acute Myeloid Leukemia

2015 ◽  
Vol 11 (4) ◽  
pp. 691-701 ◽  
Author(s):  
A. Estella-Hermoso de Mendoza ◽  
R. Castello-Cros ◽  
E. Imbuluzqueta ◽  
C. Cirauqui ◽  
R. Pippa ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Therapeutic Efficacy ◽  
Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia

2019 ◽  
Vol 11 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Andrew E. Shouksmith ◽  
Justyna M. Gawel ◽  
Nabanita Nawar ◽  
Diana Sina ◽  
Yasir S. Raouf ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Hdac Inhibitor ◽  
Oral Bioavailability ◽  
Therapeutic Efficacy ◽  
Myeloid Leukemia ◽  
Class I ◽  
Acute Myeloid

scholarly journals Noncoding RNAs in Acute Myeloid Leukemia: From Key Regulators to Clinical Players

Scientifica ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Alessandro Fatica
Keyword(s):  
Acute Myeloid Leukemia ◽  
Tumor Suppressor Genes ◽  
Myeloid Leukemia ◽  
Hematological Malignancies ◽  
Aberrant Expression ◽  
Genetic Abnormalities ◽  
Non Coding Rnas ◽  
Recent Demonstration ◽  
Acute Myeloid

Recent analyses have shown that human cells transcribe almost their entire genomes, implying the existence of a huge mass of ncRNAs. At the present, microRNAs are the most investigated regulative non-coding RNAs. Several studies have demonstrated that microRNAs play a crucial role in hematopoietic differentiation and hematological malignancies, including acute myeloid leukemia (AML). Aberrant expression of microRNAs has been associated with specific genetic abnormalities and clinical outcome of patients with AML. In addition, since microRNAs can function as either oncogenes or tumor suppressor genes, the potential of using these molecules as therapeutic targets opens up new opportunities in the future of AML therapy. The recent demonstration that other regulatory ncRNAs, in addition to microRNAs, are involved in hematopoietic cell differentiation and diseases, suggests that they may also have a biological relevance in AML. This paper will describe the role of ncRNAs in AML and discuss the expectations for the use of ncRNAs in diagnosis, prognosis, and therapy of AML.

scholarly journals Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia

Haematologica ◽  
2021 ◽  
Author(s):  
Dimitrios Papaioannou ◽  
Hatice G. Ozer ◽  
Deedra Nicolet ◽  
Amog P. Urs ◽  
Tobias Herold ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Clinical Outcome ◽  
Rna Sequencing ◽  
Clinical Significance ◽  
Genetic Variants ◽  
Myeloid Leukemia ◽  
Sequencing Data ◽  
Younger Adults ◽  
Non Coding Rnas ◽  
Acute Myeloid

Expression levels of long non-coding RNAs (lncRNAs) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNAs in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged

CRISPRi/a screening to identify functional long non-coding RNAs in pediatric acute myeloid leukemia

2016 ◽  
Vol 228 (03) ◽  
Author(s):  
M Ng ◽  
L Santer ◽  
S Emmrich ◽  
A Schwarzer ◽  
D Reinhardt ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Pediatric Acute Myeloid Leukemia ◽  
Non Coding Rnas ◽  
Acute Myeloid

scholarly journals Correction to: MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia

2018 ◽  
Vol 97 (7) ◽  
pp. 1299-1299
Author(s):  
Xiaolu Zhang ◽  
Bingnan Li ◽  
Jingya Yu ◽  
Jenny Dahlström ◽  
Anh Nhi Tran ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Therapeutic Efficacy ◽  
Myeloid Leukemia ◽  
Flt3 Inhibitors ◽  
Acute Myeloid
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