scholarly journals Clinical Application of Macroporous Ceramic to Promote Bone Healing in Veterinary Clinical Cases

2017 ◽  
Author(s):  
Pedro Olivério Pinho ◽  
José Miguel Campos ◽  
Carla Mendonça ◽  
Ana Rita Caseiro ◽  
José Domingos Santos ◽  
...  
Keyword(s):  
Clinical Application ◽  
Bone Healing ◽  
Clinical Cases

scholarly journals Cell therapy in bone healing disorders

2010 ◽  
Vol 2 (2) ◽  
pp. 20 ◽  
Author(s):  
Marcus Jäger ◽  
Philippe Hernigou ◽  
Christoph Zilkens ◽  
Monika Herten ◽  
Xinning Li ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Therapy ◽  
Bone Regeneration ◽  
Progenitor Cells ◽  
Clinical Application ◽  
Bone Healing ◽  
Bone Marrow Cells ◽  
Cell Based Therapy ◽  
Local Bone ◽  
Autologous Bone

In addition to osteosynthetic stabilizing techniques and autologous bone transplantations, so-called orthobiologics play an increasing role in the treatment of bone healing disorders. Besides the use of various growth factors, more and more new data suggest that cell-based therapies promote local bone regeneration. For ethical and biological reasons, clinical application of progenitor cells on the musculoskeletal system is limited to autologous, postpartum stem cells. Intraoperative one-step treatment with autologous progenitor cells, in particular, delivered promising results in preliminary clinical studies. This article provides an overview of the rationale for, and characteristics of the clinical application of cell-based therapy to treat osseous defects based on a review of existing literature and our own experience with more than 100 patients. Most clinical trials report successful bone regeneration after the application of mixed cell populations from bone marrow. The autologous application of human bone marrow cells which are not expanded ex vivo has medico-legal advantages. However, there is a lack of prospective randomized studies including controls for cell therapy for bone defects. Autologous bone marrow cell therapy seems to be a promising treatment option which may reduce the amount of bone grafting in future.

scholarly journals Clinical application of bone morphogenetic proteins for bone healing: a systematic review

2017 ◽  
Vol 41 (6) ◽  
pp. 1073-1083 ◽  
Author(s):  
Gopal Shankar Krishnakumar ◽  
Alice Roffi ◽  
Davide Reale ◽  
Elizaveta Kon ◽  
Giuseppe Filardo
Keyword(s):  
Systematic Review ◽  
Clinical Application ◽  
Bone Morphogenetic Proteins ◽  
Bone Healing

scholarly journals Extracorporeal magnetic stimulation of the pelvic floor neuromuscular system in urological practice

2021 ◽  
Vol 18 (4) ◽  
pp. 264-276
Author(s):  
Dmitry Yu. Pushkar ◽  
Alexander G. Kulikov ◽  
Gevorg R. Kasyan ◽  
Yuriy A. Kupriyanov ◽  
Viktoriya V. Romikh ◽  
...  
Keyword(s):  
Pelvic Floor ◽  
Clinical Application ◽  
Magnetic Stimulation ◽  
Scientific Data ◽  
Neuromuscular System ◽  
Historical Aspects ◽  
Urological Diseases ◽  
Stimulation Of ◽  
Clinical Cases

This study aimed to systematize data on the possibility of using extracorporeal magnetic stimulation of the pelvic floor neuromuscular system in urological practice. Materials and methods. Based on the available scientific data and our own clinical cases, information regarding the use of extracorporeal magnetic stimulation in the treatment of urological diseases has been summarized. The historical aspects of the application of magnetic stimulation are presented, along with the physical and biological essence of the method, and indications and contraindications to the procedures. The principles of prescribing extracorporeal magnetic stimulation of the pelvic floor neuromuscular system have also been described in detail, and international and Russian data concerning the clinical application of this method in urological practice have been summarized.

scholarly journals CLINICAL APPLICATION OF BONE MORPHOGENETIC PROTEIN ON FRACTURE HEALING PROCESS

2019 ◽  
Vol 6 (2) ◽  
pp. 48
Author(s):  
Riko Febrian Kunta Adjie
Keyword(s):  
Fracture Healing ◽  
Clinical Application ◽  
Bone Morphogenetic Proteins ◽  
Bone Healing ◽  
Healing Process ◽  
Delayed Union ◽  
Non Union ◽  
Morphogenetic Protein ◽  
Number Of Patients ◽  
And Function

Delayed union or non-union often occurs in bone healing fracture process. The clinical application of Bone Morphogenetic Proteins (BMPs) has helped an increasing number of patients achieve bone regeneration in clinical area lacking simple solutions for difficult bone healing situations. Many researches has proved that BMPs improved fracture healing regeneration. In this review article, introduction and current clinical issues are summarized on efficacy and function of BMPs. Currently, rhBMP-2 and rhBMP-7 have shown clinical significance but other subfamily members of BMPs still lacked of evidence.

scholarly journals Research Progress of Yupingfeng Powder in Clinical Application

2020 ◽  
Vol 3 (3) ◽  
pp. 6
Author(s):  
Qing Guo ◽  
Li Sun
Keyword(s):  
Clinical Application ◽  
Research Progress ◽  
Animal Pharmacology ◽  
Clinical Cases

Yupingfeng Powder is widely used in the treatment of respiratory, digestive, urinary, dermatological and ENT diseases. The author reviewed the animal pharmacology experiments and clinical cases in recent years, and summarized and analyzed the diseases he treated, providing ideas and methods for clinical users.

Strontium Ranelate in the Healing of Fractures Complicated with Delayed Union. It is Really Effective?

2017 ◽  
Vol 68 (8) ◽  
pp. 1825-1828 ◽  
Author(s):  
Paul Dan Sirbu ◽  
Razvan Tudor ◽  
Vlad Veringa ◽  
Bogdan Mihnea Ciuntu ◽  
Valentin Radu ◽  
...  
Keyword(s):  
Bone Healing ◽  
Strontium Ranelate ◽  
Bone Fractures ◽  
Bone Microarchitecture ◽  
Delayed Union ◽  
Long Bone ◽  
Open Label ◽  
Long Bone Fractures ◽  
Increased Risk ◽  
Clinical Cases

Osteoporosis is a systemic skeletal disease characterized by low bone strength, which leads to an increased risk of fracture. The primary objective of osteoporosis treatment is the prevention of fragility fractures and the secondary objective is their rapid healing if they occur. Strontium ranelate is an antiosteoporotic therapeutic agent with a double action mechanism: the increase of bone formation and the decrease of bone resorption, contributing thus to the improvement of bone healing. Preclinical studies have demonstrated the efficacy of strontium ranelate for the improvement of bone healing and bone microarhitecture, as well as of the osteointegration of implants. Some clinical cases have been reported regarding the efficacy of strontium ranelate in the healing of long bone fractures complicated by nonunion or delayed union. In the present study we have reported 2 clinical cases that demonstrate the effectiveness of the treatment with strontium ranelate (Osseor) for 3-6 months in the healing of complicated long bone fractures with delayed union. Our cases confirm the results of the open label study CL3-12911-036 (delayed union and non-union fracture study), where the treatment with 2 g/day of strontium ranelate improved healing and led to a better quality of life. Even if there are some cardiovascular contraindications, strontium ranelate is proven to reduce vertebral and non-vertebral fracture risk in osteoporosis and in the same time improves bone microarchitecture and accelerates fracture healing.

Echocardiography. Clinical application in mitral stenosis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 161-166 ◽  
Author(s):  
B. L. Segal
Keyword(s):  
Clinical Application ◽  
Mitral Stenosis
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