scholarly journals Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

2017 ◽  
Author(s):  
Ángel Serrano-Aroca
Keyword(s):  
Biomedical Applications ◽  
Polymer Properties

Direct Molding of Polymers for Biomedical Applications

2014 ◽  
Vol 611-612 ◽  
pp. 685-692
Author(s):  
Loredana Santo ◽  
Denise Bellisario ◽  
Fabrizio Quadrini
Keyword(s):  
Biomedical Applications ◽  
Raw Materials ◽  
Main Process ◽  
Molding Process ◽  
Polymer Properties ◽  
Single Pellet ◽  
Dsc Analyses ◽  
Micro Molding ◽  
Mechanical Performances ◽  
Small Parts

. Direct molding is a simple molding process to produce small parts at low costs. A single pellet or few pellets are directly molded into a transparent mound by means of an IR lamp. A new micro-molding machine has been developed for this study and used to mould polymers for biomedical applications (PCL and PHBV). Due to the small amount of molded material, the proposed process is particular suitable for biomedical applications which are characterized by small numbers of parts and high costs of the raw materials. Moreover, direct molding is able to reduce material degradation and frozen stresses. The new machine has been used to mold small disks from single pellets. This way, the effect of the main process parameters on the molded polymer density has been evaluated. Moreover, DSC analyses have shown the effect of the molding process on the polymer properties. In conclusion, the micro-molding system has been used to produce small components which were tested in terms of dimensional stability and mechanical performances.

scholarly journals Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 40
Author(s):  
Jan Ozimek ◽  
Krzysztof Pielichowski
Keyword(s):  
Biomedical Applications ◽  
Surface Characteristics ◽  
Inorganic Materials ◽  
Polyhedral Oligomeric Silsesquioxanes ◽  
Cardiovascular Stents ◽  
Fundamental Properties ◽  
Polymer Properties ◽  
Recent Developments ◽  
Bio Imaging ◽  
Material Porosity

Advanced organic-inorganic materials-composites, nanocomposites, and hybrids with various compositions offer unique properties required for biomedical applications. One of the most promising inorganic (nano)additives are polyhedral oligomeric silsesquioxanes (POSS); their biocompatibility, non-toxicity, and phase separation ability that modifies the material porosity are fundamental properties required in modern biomedical applications. When incorporated, chemically or physically, into polyurethane matrices, they substantially change polymer properties, including mechanical properties, surface characteristics, and bioactivity. Hence, this review is dedicated to POSS-PU composites that have recently been developed for applications in the biomedical field. First, different modes of POSS incorporation into PU structure have been presented, then recent developments of PU/POSS hybrids as bio-active composites for scaffolds, cardiovascular stents, valves, and membranes, as well as in bio-imaging and cancer treatment, have been described. Finally, characterization and methods of modification routes of polyurethane-based materials with silsesquioxanes were presented.

Evaluation of Thermal Properties and Physical Aging as Function of the Pendent Chain Length in Tyrosine-Derived Polycarbonates, a Class of New Biomaterials

1995 ◽  
Vol 394 ◽  
Author(s):  
Varawut Tangpasuthadol ◽  
Adi Shefer ◽  
Kimberly A. Hooper ◽  
Joachim Kohn
Keyword(s):  
Thermal Properties ◽  
Chain Length ◽  
Biomedical Applications ◽  
Physical Aging ◽  
Polymer Structure ◽  
Model System ◽  
Relaxation Kinetics ◽  
Polymer Properties ◽  
Wide Range ◽  
Biomedical Polymers

Tyrosine-derived polycarbonates are currently in preclinical evaluations for biomedical applications. Although physical aging can significantly alter a wide range of polymer properties, physical aging is has rarely been investigated for biomedical polymers. A series of four tyrosinederived polycarbonates was used as a model system to study the effect of polymer structure on the enthalpy relaxation kinetics.

Chemical structure and polymer properties of wheat and cabbage lignins – Valuable biopolymers for biomedical applications

Polymer ◽  
2021 ◽  
Vol 220 ◽  
pp. 123571
Author(s):  
Anatoly Petrovich Karmanov ◽  
Albert Vladimirovich Kanarsky ◽  
Lyudmila Sergeevna Kocheva ◽  
Vladimir Aleksandrovich Belyy ◽  
Eduard Ilyasovich Semenov ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Chemical Structure ◽  
Polymer Properties

Applications of Scanning Microscopy in Biomedical Research

1968 ◽  
Vol 26 ◽  
pp. 354-355
Author(s):  
T. L. Hayes
Keyword(s):  
Information Content ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Dental Enamel ◽  
Resolving Power ◽  
Whole Mount ◽  
Two Parameters ◽  
Content Information ◽  
Sectioned Tissue

Biomedical applications of the scanning electron microscope (SEM) have increased in number quite rapidly over the last several years. Studies have been made of cells, whole mount tissue, sectioned tissue, particles, human chromosomes, microorganisms, dental enamel and skeletal material. Many of the advantages of using this instrument for such investigations come from its ability to produce images that are high in information content. Information about the chemical make-up of the specimen, its electrical properties and its three dimensional architecture all may be represented in such images. Since the biological system is distinctive in its chemistry and often spatially scaled to the resolving power of the SEM, these images are particularly useful in biomedical research.In any form of microscopy there are two parameters that together determine the usefulness of the image. One parameter is the size of the volume being studied or resolving power of the instrument and the other is the amount of information about this volume that is displayed in the image. Both parameters are important in describing the performance of a microscope. The light microscope image, for example, is rich in information content (chemical, spatial, living specimen, etc.) but is very limited in resolving power.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

Biomedical applications: Pitfalls in the practice

1994 ◽  
Vol 52 ◽  
pp. 378-379
Author(s):  
J. D. Shelburne ◽  
Peter Ingram ◽  
Victor L. Roggli ◽  
Ann LeFurgey
Keyword(s):  
Operating Room ◽  
Liquid Nitrogen ◽  
Lung Tissue ◽  
Biomedical Applications ◽  
Microprobe Analysis ◽  
Tissue Sample ◽  
Cellular Level ◽  
Tissue Samples ◽  
Asbestos Fibers

At present most medical microprobe analysis is conducted on insoluble particulates such as asbestos fibers in lung tissue. Cryotechniques are not necessary for this type of specimen. Insoluble particulates can be processed conventionally. Nevertheless, it is important to emphasize that conventional processing is unacceptable for specimens in which electrolyte distributions in tissues are sought. It is necessary to flash-freeze in order to preserve the integrity of electrolyte distributions at the subcellular and cellular level. Ideally, biopsies should be flash-frozen in the operating room rather than being frozen several minutes later in a histology laboratory. Electrolytes will move during such a long delay. While flammable cryogens such as propane obviously cannot be used in an operating room, liquid nitrogen-cooled slam-freezing devices or guns may be permitted, and are the best way to achieve an artifact-free, accurate tissue sample which truly reflects the in vivo state. Unfortunately, the importance of cryofixation is often not understood. Investigators bring tissue samples fixed in glutaraldehyde to a microprobe laboratory with a request for microprobe analysis for electrolytes.

Biological and biomedical applications of collagenous biomaterials

1990 ◽  
Vol 48 (3) ◽  
pp. 856-857
Author(s):  
Yasushi P. Kato ◽  
Michael G. Dunn ◽  
Frederick H. Silver ◽  
Arthur J. Wasserman
Keyword(s):  
Biomedical Applications ◽  
Soft Tissues ◽  
Collagen Fibers ◽  
Bone Collagen ◽  
Cover Slip ◽  
Fibroblast Migration ◽  
Cellular Expression ◽  
Defect Repair

Collagenous biomaterials have been used for growing cells in vitro as well as for augmentation and replacement of hard and soft tissues. The substratum used for culturing cells is implicated in the modulation of phenotypic cellular expression, cellular orientation and adhesion. Collagen may have a strong influence on these cellular parameters when used as a substrate in vitro. Clinically, collagen has many applications to wound healing including, skin and bone substitution, tendon, ligament, and nerve replacement. In this report we demonstrate two uses of collagen. First as a fiber to support fibroblast growth in vitro, and second as a demineralized bone/collagen sponge for radial bone defect repair in vivo.For the in vitro study, collagen fibers were prepared as described previously. Primary rat tendon fibroblasts (1° RTF) were isolated and cultured for 5 days on 1 X 15 mm sterile cover slips. Six to seven collagen fibers, were glued parallel to each other onto a circular cover slip (D=18mm) and the 1 X 15mm cover slip populated with 1° RTF was placed at the center perpendicular to the collagen fibers. Fibroblast migration from the 1 x 15mm cover slip onto and along the collagen fibers was measured daily using a phase contrast microscope (Olympus CK-2) with a calibrated eyepiece. Migratory rates for fibroblasts were determined from 36 fibers over 4 days.

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

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