scholarly journals Microbicides for the Prevention of HPV, HIV-1, and HSV-2: Sexually Transmitted Viral Infections

2017 ◽  
Author(s):  
Naveed Shahzad ◽  
Roman Farooq ◽  
Bilal Aslam ◽  
Muhammad Umer
Keyword(s):  
Viral Infections ◽  
Sexually Transmitted ◽  
Hiv 1

Musculoskeletal disorders: genitourinary medicine perspective

1996 ◽  
Vol 7 (6) ◽  
pp. 396-399
Author(s):  
Sarup C Tayal ◽  
Peter Watson
Keyword(s):  
Rheumatoid Arthritis ◽  
Sexually Transmitted Diseases ◽  
Musculoskeletal Disorders ◽  
Musculoskeletal System ◽  
Sexually Transmitted Infection ◽  
Viral Infections ◽  
Transmitted Infection ◽  
Medical Specialties ◽  
Sexually Transmitted ◽  
Genitourinary Medicine

Summary: The association of musculoskeletal disorders and genitourinary symptoms is reviewed. Reactive arthritis, Sjogren's syndrome and rheumatoid arthritis can present with a variety of genitourinary symptoms. Similarly sexually transmitted diseases including gonorrhoea, syphilis, HIV and other viral infections can affect the musculoskeletal system. Reiter's syndrome may be a consequence of a sexually transmitted infection although its presentation can suggest that also in postdysenteric cases. The fact that conditions may present to various medical specialties requires doctors outside departments of GUM to allow their patients an opportunity and the time to discuss sexual matters.

scholarly journals Settings for identifying recent HIV infections: the Portuguese experience

2008 ◽  
Vol 13 (36) ◽  
Author(s):  
H Cortes Martins ◽  
M T Paixão
Keyword(s):  
Hiv Infections ◽  
Cross Sectional Study ◽  
Western European Country ◽  
Reference Laboratory ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Aids Epidemic ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv 1

Portugal has been the western European country with the highest rate of notified acquired immunodeficiency syndrome (AIDS) cases since 1999 and human immunodeficiency virus (HIV) infection cases since 2000. Nonetheless, exact information on the magnitude and trends of recently acquired infections is missing. In a cross-sectional study we aimed to determine HIV prevalence, the proportion of recently acquired infections and the incidence among patients attending a Sexually Transmitted Infections (STI) clinic and among HIV positive cases tested at the AIDS Reference Laboratory (ARL), by using the Avidity Index (AI) of antibodies to identify recent HIV-1 seroconversions. Demographic and behavioural data were collected. At the STI clinic 253 patients were enrolled, 16 were found to be HIV infected (14 HIV-1, 2 HIV-2) and a prevalence of 6.3% was obtained. Four recent HIV-1 infections were identified and the HIV-1 incidence was 3.3% per year. At the ARL, 332 newly diagnosed cases of HIV-1 infection were studied, 59 (17.8%) were recent infections and an annual incidence of 4.1% was estimated. These findings support STI clinics as key sentinel sites for recently acquired HIV infections and illustrate the viability of testing for recent HIV infections in these settings and reinforce the value of this method in the surveillance for better monitoring current trends of the HIV/AIDS epidemic in Portugal.

scholarly journals Human immunodeficiency virus type 1-infected individuals make autoantibodies that bind to CD43 on normal thymic lymphocytes.

1990 ◽  
Vol 172 (4) ◽  
pp. 1151-1158 ◽  
Author(s):  
B Ardman ◽  
M A Sikorski ◽  
M Settles ◽  
D E Staunton
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
T Lymphocytes ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Lupus Erythematosus ◽  
Viral Infections ◽  
Immunodeficiency Virus ◽  
Hiv 1

Sera from human immunodeficiency virus type 1 (HIV-1)-infected and -noninfected individuals were screened for antibodies that could bind to native T cell differentiation antigens. Antibodies that could immunoprecipitate CD43 (sialophorin, leukosialin) from a T cell lymphoma line were detected in sera from 27% of patients, and antibodies that could bind specifically to transfected cells expressing CD43 were detected in 47% of patients. The anti-CD43 antibodies were related to HIV-1 infection in that no patients with other chronic viral infections or systemic lupus erythematosus contained such antibodies in their sera. The anti-CD43 autoantibodies bound to a partially sialylated form of CD43 expressed by normal human thymocytes, but not by normal, circulating T lymphocytes. However, the determinant(s) recognized by the anti-CD43 autoantibodies was present on a large proportion of circulating T lymphocytes, but masked from antibody recognition by sialic acid residues. These results demonstrate that HIV-1 infection is specifically associated with the production of autoantibodies that bind to a native T cell surface antigen.

Persistence of a sexually transmitted highly resistant HIV-1: pol quasispecies evolution over 33 months in the absence of treatment

AIDS ◽  
2006 ◽  
Vol 20 (17) ◽  
pp. 2231-2233 ◽  
Author(s):  
Stefan Neifer ◽  
Sybille Somogyi ◽  
Frank Schlote ◽  
Thomas Berg ◽  
Gabriele Poggensee ◽  
...  
Keyword(s):  
Sexually Transmitted ◽  
Quasispecies Evolution ◽  
Hiv 1

scholarly journals Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males

2019 ◽  
Vol 13 (1) ◽  
pp. 118-127
Author(s):  
Clive M. Gray ◽  
Kyle L. O’Hagan ◽  
Ramon Lorenzo-Redondo ◽  
Abraham J. Olivier ◽  
Sylvie Amu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sexually Transmitted Infections ◽  
Target Cell ◽  
Langerhans Cells ◽  
Medical Male Circumcision ◽  
Sexually Transmitted ◽  
T Cell Migration ◽  
Cell Changes ◽  
The Impact ◽  
Hiv 1

Abstract We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the impact of sexually transmitted infections (STIs) on the density and location of T and Langerhans cells. Chemokine C–C ligand 27 (CCL27) was expressed 6.94-fold higher in the inner foreskin when compared with the outer foreskin. We show that the density of CD4+CCR5+ cells/mm2 was higher in the epithelium of the inner foreskin, regardless of STI status, in parallel with higher CCL27 gene expression. In the presence of STIs, there were higher numbers of CD4+CCR5+ cells/mm2 cells in the sub-stratum of the outer and inner foreskin with concurrently higher number of CD207+ Langerhans cells (LC) in both tissues, with the latter cells being closer to the keratin surface of the outer FS in the presence of an STI. When we tested the ability of exogenous CCL27 to induce T-cell migration in foreskin tissue, CD4 + T cells were able to relocate to the inner foreskin epithelium in response. We provide novel insight into the impact CCL27 and STIs on immune and HIV-1 target cell changes in the foreskin.

scholarly journals Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives

2014 ◽  
Vol 2014 ◽  
pp. 1-24 ◽  
Author(s):  
P. J. Klasse
Keyword(s):  
Cellular Immunity ◽  
Neutralizing Antibodies ◽  
Viral Infections ◽  
Viral Proteins ◽  
Virus Neutralization ◽  
Virus Infectivity ◽  
Viral Pathogens ◽  
Enveloped Viruses ◽  
Vaccine Candidates ◽  
Hiv 1

Neutralizing antibodies (NAbs) can be both sufficient and necessary for protection against viral infections, although they sometimes act in concert with cellular immunity. Successful vaccines against viruses induce NAbs but vaccine candidates against some major viral pathogens, including HIV-1, have failed to induce potent and effective such responses. Theories of how antibodies neutralize virus infectivity have been formulated and experimentally tested since the 1930s; and controversies about the mechanistic and quantitative bases for neutralization have continually arisen. Soluble versions of native oligomeric viral proteins that mimic the functional targets of neutralizing antibodies now allow the measurement of the relevant affinities of NAbs. Thereby the neutralizing occupancies on virions can be estimated and related to the potency of the NAbs. Furthermore, the kinetics and stoichiometry of NAb binding can be compared with neutralizing efficacy. Recently, the fundamental discovery that the intracellular factor TRIM21 determines the degree of neutralization of adenovirus has provided new mechanistic and quantitative insights. Since TRIM21 resides in the cytoplasm, it would not affect the neutralization of enveloped viruses, but its range of activity against naked viruses will be important to uncover. These developments bring together the old problems of virus neutralization—mechanism, stoichiometry, kinetics, and efficacy—from surprising new angles.

Prevalence of HIV-1, HIV-2 and HTLV antibody, in Fortaleza, Ceara, Brazil, 1993-1994

1996 ◽  
Vol 7 (5) ◽  
pp. 365-369 ◽  
Author(s):  
N. Broutet ◽  
A. de Queiroz Sousa ◽  
F. Placido Basilio ◽  
H. Luis Sa ◽  
F. Simon
Keyword(s):  
Pregnant Women ◽  
Sex Workers ◽  
Transmitted Disease ◽  
Risk Groups ◽  
Northeastern Brazil ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
T Lymphotropic Virus ◽  
Commercial Enzyme Immunoassay ◽  
Hiv 1

To evaluate the respective part of HIV-1, HIV-2 and human T lymphotropic virus (HTLV) infection in Fortaleza, the principal city of the Ceara state (Northeast of Brazil), a cross-sectional seroepidemiological survey was conducted from July 1993 to February 1994 in 6 selected groups: pregnant women, tuberculosis (Tb) patients, sexually transmitted disease (STD) patients, female and male commercial sex workers (CSWs) and prisoners. Sera were screened by Mixt HIV-1/HIV-2 commercial enzyme immunoassay and ELISA HTLV I/II. Each serum found positive by ELISA was confirmed by Western blot. A total of 2917 persons were interviewed, of whom 2754 (94.4%) agreed to participate and gave a blood sample. Twenty-eight were found to be HIV-1 antibody positive. The prevalence ranged from 0.25% in pregnant women to 2.9% in male CSWs. The prevalence was 1% in STD patients and 0.44% in Tb patients. None of the sera was found positive for HIV-2. The prevalence of antibodies to HTLV-I varied from 0.12% in pregnant women to 1.21% in female CSWs. Five sera were positive for HTLV-II. These results confirm the hypothesis that the HIV epidemic in Northeastern Brazil is still limited to high risk groups. Repeated cross-sectional surveys of this type should be performed as a surveillance tool to study the dynamics of this epidemic in low prevalence areas. Defining risk factors should allow targeting of intervention strategies.

scholarly journals Male sex workers in Moscow, Russia: a pilot study of demographics, substance use patterns, and prevalence of HIV-1 and sexually transmitted infections

AIDS Care ◽  
2009 ◽  
Vol 22 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Stefan Baral ◽  
Darya Kizub ◽  
Nicole Franck Masenior ◽  
Alena Peryskina ◽  
Julie Stachowiak ◽  
...  
Keyword(s):  
Substance Use ◽  
Pilot Study ◽  
Sexually Transmitted Infections ◽  
Sex Workers ◽  
Male Sex Workers ◽  
Sexually Transmitted ◽  
Use Patterns ◽  
Male Sex ◽  
Hiv 1

Treatment: infectious diseases

2018 ◽  
Author(s):  
David A. Warrell ◽  
Matthew Dryden ◽  
Alastair Miller ◽  
Clare Morgan ◽  
David A. Warrell
Keyword(s):  
Infectious Diseases ◽  
Sexually Transmitted Infections ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Emerging Infections ◽  
Sexually Transmitted

Introduction: infectious diseases - Viral infections - Bacterial infections - Malaria - Other protozoal infections - Filarial worms - Worm infections - Flukes - Emerging infections - Sexually transmitted infections

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