scholarly journals Physical Limitations to Tissue Engineering of Intervertabral Disc Cells

10.5772/8587 ◽  
2010 ◽  
Author(s):  
Shigeru Kobayashi ◽  
Hisatoshi Baba ◽  
Kenichi Takeno ◽  
Tsuyoshi Miyazaki ◽  
Adam Meir ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Disc Cells ◽  
Physical Limitations

Cell shape and gene expression in human intervertebral disc cells: in vitro tissue engineering studies

2003 ◽  
Vol 78 (2) ◽  
pp. 109-117 ◽  
Author(s):  
He Gruber ◽  
Ja Ingram ◽  
K Leslie ◽  
Hj Norton ◽  
En Hanley Jr
Keyword(s):  
Gene Expression ◽  
Tissue Engineering ◽  
Intervertebral Disc ◽  
Cell Shape ◽  
Engineering Studies ◽  
Disc Cells

Efficient Nonviral Transfection of Primary Intervertebral Disc Cells by Electroporation for Tissue Engineering Application

2017 ◽  
Vol 23 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Rahel D. May ◽  
Adel Tekari ◽  
Daniela A. Frauchiger ◽  
Anna Krismer ◽  
Lorin M. Benneker ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Intervertebral Disc ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Nonviral Transfection ◽  
Disc Cells

scholarly journals Clinically Relevant Cell Sources for TMJ Disc Engineering

2008 ◽  
Vol 87 (6) ◽  
pp. 548-552 ◽  
Author(s):  
D.E. Johns ◽  
M.E. Wong ◽  
K.A. Athanasiou
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Dermal Fibroblast ◽  
Dermal Fibroblasts ◽  
Compressive Properties ◽  
Tissue Engineering Approach ◽  
Tmj Disc ◽  
Cell Sources ◽  
Disc Cells ◽  
Costal Chondrocyte

Tissue-engineering of the temporomandibular joint (TMJ) disc aims to provide patients with TMJ disorders an option to replace diseased tissue with autologous, functional tissue. This study examined clinically relevant cell sources by comparing costal chondrocytes, dermal fibroblasts, a mixture of the two, and TMJ disc cells in a scaffoldless tissue-engineering approach. It was hypothesized that all constructs would produce matrix relevant to the TMJ disc, but the mixture constructs were expected to appear most like the TMJ disc constructs. Costal chondrocyte and mixture constructs were morphologically and biochemically superior to the TMJ disc and dermal fibroblast constructs, and their compressive properties were not significantly different. Costal chondrocyte constructs produced almost 40 times more collagen and 800 times more glycosaminoglycans than did TMJ constructs. This study demonstrates the ability of costal chondrocytes to produce extracellular matrix that may function in a TMJ disc replacement.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Thoughts on Grammar Intervention in AAC

2008 ◽  
Vol 17 (2) ◽  
pp. 43-49 ◽  
Author(s):  
Marc Fey
Keyword(s):  
Language Impairment ◽  
Specific Language Impairment ◽  
Augmentative And Alternative Communication ◽  
Communication Systems ◽  
Target Language ◽  
Alternative Communication ◽  
Physical Limitations ◽  
Communication Needs ◽  
Communication Interventions ◽  
Planning Intervention

Abstract In this article, I propose that, for several reasons, grammar should be an early focus of communication interventions for young children using augmentative and alternative communication (AAC) systems. The basic goals for such programs should be to facilitate the child's comprehension of the language of the community, or the target language, thus leading the way to literacy, and to foster the child's use of symbol combinations that mirror the grammatical patterns of speaking children acquiring the target language, even if they cannot be fully grammatically complete. I introduce five principles that underlie most successful approaches to grammar interventions with children with specific language impairment. My initial attempts to apply these principles to interventions with children with complex communication needs indicate that they may be of considerable value to clinicians planning intervention programs. On the other hand, the challenges posed by the intellectual and physical limitations of many AAC users and their communication systems make it necessary to modify at least Principle 5 if the basic goals of intervention are to be met.

New AAC Access Strategy for Gesture Tracking: A Technical Note

2012 ◽  
Vol 21 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Susan Fager ◽  
Tom Jakobs ◽  
David Beukelman ◽  
Tricia Ternus ◽  
Haylee Schley
Keyword(s):  
Augmentative And Alternative Communication ◽  
Technical Note ◽  
Head Tracking ◽  
Alternative Communication ◽  
Access Methods ◽  
Cord Injury ◽  
Physical Limitations ◽  
Gesture Tracking ◽  
Communication Needs ◽  
Tracking Device

Abstract This article summarizes the design and evaluation of a new augmentative and alternative communication (AAC) interface strategy for people with complex communication needs and severe physical limitations. This strategy combines typing, gesture recognition, and word prediction to input text into AAC software using touchscreen or head movement tracking access methods. Eight individuals with movement limitations due to spinal cord injury, amyotrophic lateral sclerosis, polio, and Guillain Barre syndrome participated in the evaluation of the prototype technology using a head-tracking device. Fourteen typical individuals participated in the evaluation of the prototype using a touchscreen.

Responding to Clinicians' Challenges in Working With Geriatric Patients

2011 ◽  
Vol 16 (1) ◽  
pp. 22-29
Author(s):  
Lisa Y. Milliken ◽  
Dawn Ralph ◽  
Sally Jones-McNamara
Keyword(s):  
Health Care ◽  
Geriatric Patients ◽  
Clinical Scenario ◽  
Medical Diagnoses ◽  
Communication Deficits ◽  
Resident Care ◽  
Physical Limitations

Clinicians work with older residents who have not only multiple physical limitations, but cognitive loss, communication deficits, dysphagia, and multiple medical diagnoses. They must work within procedural, regulatory, and reimbursement systems that challenge them to provide optimal resident care. In this article, the authors will discuss some specific challenges brought forth by clinicians in response to a clinical scenario and will provide information and feedback from several health-care consultants.

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