scholarly journals Influencing the Effect of Treatment of Diseases Related to Bone Remodelling by Dynamic Loading

10.5772/7082 ◽  
2010 ◽  
Author(s):  
Vclav Klika ◽  
Frantiek Mark ◽  
Ivo Mak
Bone ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 276
Author(s):  
A.G. Torrance ◽  
R. Suswillo ◽  
L.E. Lanyon ◽  
A. Boyde

1981 ◽  
Vol 96 (1) ◽  
pp. 24-29 ◽  
Author(s):  
L. G. Sobrinho ◽  
M. C. Nunes ◽  
C. Calhaz-Jorge ◽  
J. C. Maurício ◽  
M. A. Santos

Abstract. Eleven consecutive patients with large prolactinomas were treated for 6 months with bromocriptine, (7.5 mg/day). Nine had invasion of the sphenoidal sinus, one a visual field defect and one a secondary trigeminal neuralgia. At the end of the treatment period 8 of the first 9 patients showed radiographical signs of bone remodelling and/or actual reduction of the tumour size. The last 2 patients had complete disappearance of their symptoms. The remissions could be observed as early as 3 weeks after the start of the treatment. Two patients suffered acute, reversible (partial in one case) episodes of loss of vision during the study. During the treatment the prolactin values decreased in all patients to an average of 1.7% of the baseline levels. There was a steep rise in the serum prolactin concentrations after withdrawal of the drug. After one month there was a plateauing at a high level, although lower than basal level. Libido and potency were restored in all 3 males studied. Two of the females experienced orgasm for the first time in their lives after some years of primary frigidity. It is concluded that bromocriptine reproducibly reduces the size of prolactinomas. This effect can be observed shortly after the beginning of the treatment and is at least partially reversible. Episodes of pituitary apoplexy may occur during the treatment of large tumours despite an otherwise favourable response.


2004 ◽  
Vol 171 (4S) ◽  
pp. 294-294
Author(s):  
Yufeng Zhou ◽  
Charles G. Marguet ◽  
Michaella E. Maloney ◽  
Franklin H. Cocks ◽  
Glenn M. Preminger ◽  
...  

2012 ◽  
Vol 224 (03) ◽  
Author(s):  
JT Tauer ◽  
A Ulmer ◽  
LC Hofbauer ◽  
M Suttorp

1962 ◽  
Vol 02 (02) ◽  
pp. 165-172
Author(s):  
C Miras ◽  
G Lewis ◽  
J Mantzos

Summary1. Separated leukocytes or total blood from normal subjects, untreated leukaemic patients and from leukaemic patients treated with cytostatic agents were incubated with CH3COONa-l-C14. Radioactivity of mixed lipids was measured at standard time intervals.2. The time incorporation curve observed with leukocytes from treated leukaemic patients showed after an initial linear part, a more rapid levelling off than the curves observed with leukocytes from untreated and normal subjects.3. Therefore, an indirect effect of treatment on leukocyte lipid synthesis seems to be present.4. Phospholipid and neutral lipid synthesis by leukaemic leukocytes was also studied. The results give no evidence that these fractions as a whole have any precursor-product relation.


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