scholarly journals The Role of Nucleotides in Glial Cells during Peripheral Nerve Trauma and Compressive Disorders

10.5772/68068 ◽  
2017 ◽  
Author(s):  
Marina Manhães ◽  
Marcelo Cesar ◽  
Rayssa Justo ◽  
Mauro Geller ◽  
Mendel Suchmacher ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Glial Cells ◽  
Peripheral Nerve Trauma ◽  
Nerve Trauma

Post-traumatic neuroma due to closed nerve injury. Is recovery after peripheral nerve trauma related to ultrasonographic neuroma size?

2015 ◽  
Vol 139 ◽  
pp. 314-318 ◽  
Author(s):  
Daniele Coraci ◽  
Costanza Pazzaglia ◽  
Pietro Emiliano Doneddu ◽  
Carmen Erra ◽  
Ilaria Paolasso ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Traumatic Neuroma ◽  
Post Traumatic ◽  
Peripheral Nerve Trauma ◽  
Nerve Trauma

scholarly journals Restoration of Neurological Function Following Peripheral Nerve Trauma

2020 ◽  
Vol 21 (5) ◽  
pp. 1808 ◽  
Author(s):  
Damien P. Kuffler ◽  
Christian Foy
Keyword(s):  
Peripheral Nerve ◽  
Functional Recovery ◽  
Recovery Of Function ◽  
Sensory Nerve ◽  
Standard Technique ◽  
Neurological Function ◽  
Neurological Recovery ◽  
Nerve Grafts ◽  
Peripheral Nerve Trauma ◽  
Nerve Trauma

Following peripheral nerve trauma that damages a length of the nerve, recovery of function is generally limited. This is because no material tested for bridging nerve gaps promotes good axon regeneration across the gap under conditions associated with common nerve traumas. While many materials have been tested, sensory nerve grafts remain the clinical “gold standard” technique. This is despite the significant limitations in the conditions under which they restore function. Thus, they induce reliable and good recovery only for patients < 25 years old, when gaps are <2 cm in length, and when repairs are performed <2–3 months post trauma. Repairs performed when these values are larger result in a precipitous decrease in neurological recovery. Further, when patients have more than one parameter larger than these values, there is normally no functional recovery. Clinically, there has been little progress in developing new techniques that increase the level of functional recovery following peripheral nerve injury. This paper examines the efficacies and limitations of sensory nerve grafts and various other techniques used to induce functional neurological recovery, and how these might be improved to induce more extensive functional recovery. It also discusses preliminary data from the clinical application of a novel technique that restores neurological function across long nerve gaps, when repairs are performed at long times post-trauma, and in older patients, even under all three of these conditions. Thus, it appears that function can be restored under conditions where sensory nerve grafts are not effective.

Surgical aspects of peripheral nerve trauma

1974 ◽  
Vol 11 (9) ◽  
pp. 1-62 ◽  
Author(s):  
Thomas B. Ducker ◽  
Warren B. Garrison
Keyword(s):  
Peripheral Nerve ◽  
Surgical Aspects ◽  
Peripheral Nerve Trauma ◽  
Nerve Trauma

Perifeer zenuwletsel en het effect van vitamines op het herstelproces

2021 ◽  
Author(s):  
M. DESCHRIJVER ◽  
K. BULKMANS ◽  
I. VANWALLEGHEM ◽  
S. GEERS
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Recovery Process ◽  
Surgical Reconstruction ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Peripheral Nerve Trauma ◽  
Nerve Trauma

Peripheral nerve injury and the effect of vitamins on the recovery process Although peripheral nerve injuries are usually not life-threatening, they can have a significant impact on the patient’s quality of life and daily functioning, with typical symptoms such as complete paralysis or severe neuropathic pain. The peripheral nervous system is capable of some regeneration and recovery, allowing conservative treatment in mild to moderate nerve damage. For severe peripheral nerve injuries surgical reconstruction remains the golden standard. However, despite the extensive knowledge of the pathophysiology of peripheral nerve trauma, a full functional recovery after a severe peripheral nerve injury is rare with the current therapeutic options. Success depends on a variety of factors: location and severity of the injury, age and physical condition of the patient, therapeutical approach, … Therefore, it is important to search for the best possible means to achieve maximal functional recovery. This article first discusses the current knowledge about the pathophysiology of peripheral nerve trauma, highlighting the most important factors that influence the recovery process. Subsequently, it will render a review of the influence of vitamins A/B/C/D/E/K on this recovery process: vit B and D seem to enhance the regeneration process of nerves and the functional recovery of the end organ, while vit C and E show an important antinociceptive effect.

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