scholarly journals Kallistatin in Sepsis: Protective Actions and Potential Therapeutic Applications

Sepsis ◽  
10.5772/67988 ◽  
2017 ◽  
Author(s):  
Julie Chao ◽  
Pengfei Li ◽  
Lee Chao
Keyword(s):  
Therapeutic Applications ◽  
Protective Actions

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Melatonin: Protection of the Intervertebral Disc

2019 ◽  
Vol 2 (3) ◽  
pp. 1-9
Author(s):  
Russel J Reiter ◽  
Sergio Rosales-Corral ◽  
Ramaswamy Sharma
Keyword(s):  
Intervertebral Disc ◽  
Molecular Mechanisms ◽  
Intervertebral Discs ◽  
Lumbar Pain ◽  
Low Back ◽  
Work Time ◽  
Protective Actions ◽  
Aging Populations ◽  
Definition Of ◽  
Endogenous Melatonin

     Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies.  The loss of work time as a result of this problem is massive.  Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actions. 

Detection, Identification and Structural Elucidation of Flavonoids using Liquid Chromatography Coupled to Mass Spectrometry

2020 ◽  
Vol 24 (1) ◽  
pp. 104-112 ◽  
Author(s):  
Krzysztof Kamil Wojtanowski ◽  
Tomasz Mroczek
Keyword(s):  
Mass Spectrometry ◽  
Central Nervous System ◽  
Nuclear Magnetic Resonance ◽  
Liquid Chromatography ◽  
High Performance ◽  
Short Review ◽  
Structural Elucidation ◽  
High Throughput Analysis ◽  
Protective Actions ◽  
The Central Nervous System

Flavonoids are one of the most common secondary metabolites occurring in plants. Their activity in the Central Nervous System (CNS) including sedative, anxiolytic, anti-convulsive, anti-depressant and neuro-protective actions is well known and documented. The most popular methods for detection, identification and structural elucidation of flavonoids are these based on Nuclear Magnetic Resonance (NMR) and mass spectrometry (MS). NMR allows rapid, high throughput analysis of crude extracts and also gives stereochemical details about identified substances. However, these methods are expensive and less sensitive than MS-based techniques. Combining High Performance Liquid Chromatography (HPLC) with MS detection gives the most powerful tool for analysis of flavonoids occurring in plants. There is a lot of different approaches to use LC/MS based techniques for identification of flavonoids and this short review shows the most important.

Pharmacology and Therapeutic Applications of A1 Adenosine Receptor Ligands

2003 ◽  
Vol 3 (4) ◽  
pp. 369-385 ◽  
Author(s):  
Arvinder Dhalla ◽  
John Shryock ◽  
Revati Shreeniwas ◽  
Luiz Belardinelli
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A1 Adenosine Receptor ◽  
Therapeutic Applications ◽  
Adenosine Receptor Ligands

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

2020 ◽  
Vol 16 ◽  
Author(s):  
Vitor F. Ferreira ◽  
Alcione S. de Carvalho ◽  
Patricia G. Ferreira ◽  
Carolina G. S. Lima ◽  
Fernando de C. da Silva
Keyword(s):  
Drug Combination ◽  
Medicinal Chemistry ◽  
Pharmaceutical Market ◽  
Important Class ◽  
Therapeutic Applications ◽  
New Applications ◽  
Pharmaceutical Uses

Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases. Objective: The aim of this review was to provide an overview on the quinones that have become drugs for several therapeutic applications. Method: We have comprehensively and critically discussed all the information available in the literature about quinonebased drugs. Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses. Conclusion: The number of studies related to quinone drugs for different pharmaceutical uses shows that the interest in new applications still increasing in recent years.

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