Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

Marine Drugs ◽

10.3390/md8041469 ◽

2010 ◽

Vol 8 (4) ◽

pp. 1469-1481 ◽

Cited By ~ 47

Author(s):

Jian-ye Zhang ◽

Li-yang Tao ◽

Yong-ju Liang ◽

Li-ming Chen ◽

Yan-jun Mi ◽

...

Keyword(s):

Secondary Metabolites ◽

Endophytic Fungi ◽

Anticancer Agents

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Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

Molecules ◽

10.3390/molecules27010296 ◽

2022 ◽

Vol 27 (1) ◽

pp. 296

Author(s):

Md. Hridoy ◽

Md. Zobayer Hossain Gorapi ◽

Sadia Noor ◽

Nargis Sultana Chowdhury ◽

Md. Mustafizur Rahman ◽

...

Keyword(s):

Cost Effectiveness ◽

Antitumor Activity ◽

Genetic Engineering ◽

Endophytic Fungi ◽

Anticancer Agents ◽

Host Plants ◽

Purification And Characterization ◽

Anticancer Compounds ◽

Comprehensive Review ◽

Lung Cancers

Endophytic fungi are microorganisms that exist almost ubiquitously inside the various tissues of living plants where they act as an important reservoir of diverse bioactive compounds. Recently, endophytic fungi have drawn tremendous attention from researchers; their isolation, culture, purification, and characterization have revealed the presence of around 200 important and diverse compounds including anticancer agents, antibiotics, antifungals, antivirals, immunosuppressants, and antimycotics. Many of these anticancer compounds, such as paclitaxel, camptothecin, vinblastine, vincristine, podophyllotoxin, and their derivatives, are currently being used clinically for the treatment of various cancers (e.g., ovarian, breast, prostate, lung cancers, and leukemias). By increasing the yield of specific compounds with genetic engineering and other biotechnologies, endophytic fungi could be a promising, prolific source of anticancer drugs. In the future, compounds derived from endophytic fungi could increase treatment availability and cost effectiveness. This comprehensive review includes the putative anticancer compounds from plant-derived endophytic fungi discovered from 1990 to 2020 with their source endophytic fungi and host plants as well as their antitumor activity against various cell lines.

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Root Endophytic Fungi: Research Update

Journal of Biology and Life Science ◽

10.5296/jbls.v5i2.5960 ◽

2014 ◽

Vol 5 (2) ◽

pp. 135 ◽

Cited By ~ 14

Author(s):

Neha Chadha ◽

Manjita Mishra ◽

Ram Prasad ◽

Ajit Varma

Keyword(s):

Secondary Metabolites ◽

Endophytic Fungi ◽

Anticancer Agents ◽

Extracellular Enzymes ◽

Fungal Endophytes ◽

Stressed Condition ◽

Plant Tolerance ◽

Therapeutic Drugs ◽

Root Endophytic Fungi ◽

Metabolites Production

Fungal endophytes are group of microorganisms that reside asymptomatically within the healthy living tissue. Root endophytic fungi like dark septate endophytes (DSE), Piriformospora indica, and Trichoderma show mutualistic association with many plant species. The endophytes are known to produce a diverse group of secondary metabolites, extracellular enzymes, antibiotics, antifungal, anticancer agents that can be used as therapeutic drugs, agrochemicals or in industries. Plants associated with fungal endophytes play an important role in the survival of plants in extreme stressed condition. This review focuses on the functions of fungal root endophytes, their relationship with host plant, tolerance to abiotic stress and secondary metabolites production against various pathogens.

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