scholarly journals NeuroPharmacology: As Applied to Designing New Chemotherapeutic Agents

10.5772/67591 ◽  
2017 ◽  
Author(s):  
Andrew H. Rodgers ◽  
Lee Roy Morgan
Keyword(s):  
Chemotherapeutic Agents ◽  
New Chemotherapeutic Agents

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

scholarly journals Secondary Metabolites from Saccharomyces cerevisiae Species with Anticancer Potential

2021 ◽  
Author(s):  
Muhammad Jahangeer ◽  
Areej Riasat ◽  
Zahed Mahmood ◽  
Muhammad Numan ◽  
Naveed Munir ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Secondary Metabolites ◽  
Apoptotic Cell ◽  
Inhibitory Effect ◽  
Chemotherapeutic Agents ◽  
Chemotherapeutic Drugs ◽  
Central Metabolism ◽  
Biotic Stresses ◽  
Micro Organisms ◽  
New Chemotherapeutic Agents

Chemotherapeutic agents produce from numerous sources such as animals, plants and micro-organisms are derived from the natural products. Although the existing therapeutic pipeline lacks fungal-derived metabolites, but hundreds of secondary metabolites derived from fungi are known to be possible chemotherapies. Over the past three decades, several secondary metabolites such as flavonoids, alkaloids, phenolic and polyketides have been developed by Saccharomyces cerevisiae species with exciting activities that considered valued for the growth of new chemotherapeutic agents. Many secondary metabolites are protective compounds which prevent abiotic and biotic stresses, i.e. predation, infection, drought and ultraviolet. Though not taking part in a living cell’s central metabolism, secondary metabolites play an important role in the function of an organism. Nevertheless, due to slow biomass build-up and inadequate synthesis by the natural host the yield of secondary metabolites is low by direct isolation. A detailed comprehension of biosynthetic pathways for development of secondary metabolites are necessary for S. cerevisiae biotransformation. These metabolites have higher inhibitory effect, specificity among cancer and normal cells, and the mechanism of non-apoptotic cell killing. This study shows the significance of bioactive compounds produced by S. cerevisiae species with their possible activity and value in chemotherapeutic drugs pipeline. The isolation and alteration of these natural secondary metabolites would promote the development of chemotherapeutic drugs.

New Chemotherapeutic Agents in Enterohepatitis (Blackhead) of Turkeys

Science ◽  
1950 ◽  
Vol 111 (2896) ◽  
pp. 720-721 ◽  
Author(s):  
E. Waletzky ◽  
J. H. Clark ◽  
H. W. Marson
Keyword(s):  
Chemotherapeutic Agents ◽  
New Chemotherapeutic Agents
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