Flavonoids: Promising Natural Products for Treatment of Skin Cancer (Melanoma)

Natural Products and Cancer Drug Discovery ◽

10.5772/67573 ◽

2017 ◽

Author(s):

Raimundo Gonçalves de Oliveira Júnior ◽

Christiane Adrielly Alves Ferraz ◽

Mariana Gama e Silva ◽

Érica Martins de Lavor ◽

Larissa Araújo Rolim ◽

...

Keyword(s):

Natural Products ◽

Skin Cancer

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A Novel Marine Natural Product Derived Pyrroloiminoquinone with Potent Activity against Skin Cancer Cells

Marine Drugs ◽

10.3390/md17080443 ◽

2019 ◽

Vol 17 (8) ◽

pp. 443 ◽

Cited By ~ 4

Author(s):

Jaden Cowan ◽

Mohammad Shadab ◽

Dwayaja H. Nadkarni ◽

Kailash KC ◽

Sadanandan E. Velu ◽

...

Keyword(s):

Natural Products ◽

Side Effects ◽

Skin Cancer ◽

Cancer Cells ◽

Natural Product ◽

The United States ◽

Marine Natural Product ◽

Migration And Invasion ◽

Migration Assay ◽

Lead Compounds

Non-melanoma skin cancer is one of the major ailments in the United States. Effective drugs that can cure skin cancers are limited. Moreover, the available drugs have toxic side effects. Therefore, skin cancer drugs with less toxic side effects are urgently needed. To achieve this goal, we focused our work on identifying potent lead compounds from marine natural products. Five lead compounds identified from a class of pyrroloiminoquinone natural products were evaluated for their ability to selectively kill squamous cell carcinoma (SCC13) skin cancer cells using an MTT assay. The toxicity of these compounds was also evaluated against the normal human keratinocyte HaCaT cell line. The most potent compound identified from these studies, C278 was further evaluated for its ability to inhibit cancer cell migration and invasion using a wound-healing assay and a trans-well migration assay, respectively. To investigate the molecular mechanism of cell death, the expression of apoptotic and autophagy proteins was studied in C278 treated cells compared to untreated cells using western blot. Our results showed that all five compounds effectively killed the SCC13 cells, with compound C278 being the most effective. Compound C278 was more effective in killing the SCC13 cells compared to HaCaT cells with a two-fold selectivity. The migration and the invasion of the SCC13 cells were also inhibited upon treatment with compound C278. The expression of pro-apoptotic and autophagy proteins with concomitant downregulation in the expression of survival proteins were observed in C278 treated cells. In summary, the marine natural product analog compound C278 showed promising anticancer activity against human skin cancer cells and holds potential to be developed as an effective anticancer agent to combat skin cancer.

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Medicinal plants towards modeling skin cancer

Current Drug Targets ◽

10.2174/1389450121666201005103521 ◽

2020 ◽

Vol 21 ◽

Author(s):

Mohammad El-Harakeh ◽

Sara Al-Ghadban ◽

Rémi Safi

Keyword(s):

Squamous Cell Carcinoma ◽

Natural Products ◽

Skin Cancer ◽

Medicinal Plants ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Chemopreventive Agents ◽

Melanoma Cancer ◽

Crude Extracts ◽

Novel Approach

: Skin cancer remains a major cause of mortality worldwide. It can be divided into melanoma and non-melanoma cancer which comprises mainly squamous cell carcinoma and basal cell carcinoma. Although conventional therapies have ameliorated the management of skin cancer, the search for chemopreventive compounds is still the most effective and safer strategy to treat cancer. Nowadays, chemoprevention is recognized as a novel approach to prevent or inhibit carcinogenesis steps by the use of natural products. Crude extracts of plants and isolated phytocompounds are considered chemopreventive agents since they harbor anti-inflammatory, antioxidant and anti-oncogenic properties against many types of diseases and cancers. In this review, we will discuss the therapeutic effect and preventive potential of selected medicinal plants used as crude extracts or as phytocompounds against melanoma and non-melanoma cutaneous cancers.

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