scholarly journals Vitamin D and Colorectal Carcinogenesis

10.5772/67397 ◽  
2017 ◽  
Author(s):  
Argjira Juniku-Shkololli
Keyword(s):  
Vitamin D ◽  
Colorectal Carcinogenesis

scholarly journals Role of Vitamin D in Preventing Colorectal Carcinogenesis

2021 ◽  
Vol 11 ◽  
pp. 123-133
Author(s):  
Fauzan Herdian ◽  
Fahmi Radityamurti ◽  
Tiara Bunga Mayang Permata ◽  
Handoko Handoko ◽  
Henry Kodrat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Gene Transcription ◽  
Colorectal Adenoma ◽  
Relevant Literature ◽  
Colorectal Carcinogenesis ◽  
Signalling Pathways ◽  
Original Research ◽  
Metastatic Progression ◽  
Vitamin D Levels

Introduction: Colorectal carcinoma is one of the cancers with a high disease burden globally. Previous observational studies have found a connection between colorectal cancer incidence with sunlight exposure and vitamin D levels. Subsequent studies investigated this relationship further and found various anti-tumoral pathways regulated by vitamin D in colorectal tissue. This paper aims to elucidate the actions of those pathways in preventing the malignant transformation of the colorectal cell by reviewing relevant literature. Methods: A search was conducted on several medical literature electronic databases for original research studying the effects of vitamin D treatment on colorectal adenoma and colorectal cancer and its underlying anti-tumoral mechanism. A total of 122 studies were included for evaluation. Results: Twenty-seven studies passed for analysis. These in vitro and in vivo study reveals that vitamin D treatment can suppress cell proliferation, induce apoptosis, maintain cellular differentiation, reduce the pro-inflammatory response, inhibit angiogenesis, and hinder metastatic progression in colorectal cancer and colorectal adenoma cells by regulating associated gene transcription or directly prevents activation of selected signalling pathways. Five studies have also shown that adding calcium to vitamin D treatment increases the anti-tumoral activity of vitamin D through cross-talk between both of their pathways. Conclusion: Vitamin D could potentially impede colorectal cancer transformation and growth through interaction with various signalling pathways and regulating gene transcription. Further clinical studies are needed to confirm whether vitamin D can be used as the basis of targeted colorectal cancer therapy using its inherent anti-tumoral properties.

scholarly journals The Role of Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer Risk

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1379
Author(s):  
Ippokratis Messaritakis ◽  
Asimina Koulouridi ◽  
Maria Sfakianaki ◽  
Konstantinos Vogiatzoglou ◽  
Nikolaos Gouvas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bacillus Stearothermophilus ◽  
Receptor Gene ◽  
Stage Iv ◽  
Colorectal Carcinogenesis ◽  
Thermus Aquaticus ◽  
Vdr Gene

Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality. Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations. The aim of the study was the investigation of the relevance of rs731236; Thermus aquaticus I (TaqI), rs7975232; Acetobacter pasteurianus sub. pasteurianus I (ApaI), rs2228570; Flavobacterium okeanokoites I (FokI) and rs1544410, Bacillus stearothermophilus I (BsmI) polymorphisms of the VDR gene to colorectal carcinogenesis (CRC) and progression. Peripheral blood was obtained from 397 patients with early operable stage II/III (n = 202) and stage IV (n = 195) CRC. Moreover, samples from 100 healthy donors and 40 patients with adenomatous polyps were also included as control groups. Genotyping in the samples from patients and controls was performed using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). A significant association was revealed between all four polymorphisms and cancer. Individuals with homozygous mutant (tt, aa, ff or bb) genotypes were more susceptible to the disease (p < 0.001). All of the mutant genotypes detected were also significantly associated with stage IV (p < 0.001), leading to significantly decreased survival (p < 0.001). Moreover, all four polymorphisms were significantly associated with KRAS (Kirsten ras oncogene) mutations and Toll-like receptor (TLR2, TLR4 and TLR9) genetic variants. In multivariate analysis, tt, aa and ff genotypes emerged as independent factors associated with decreased overall survival (OS) (p = 0.001, p < 0.001 and p = 0.001, respectively). The detection of higher frequencies of the VDR polymorphisms in CRC patients highlights the role of these polymorphisms in cancer development and progression.

scholarly journals Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case - control study

1996 ◽  
Vol 74 (1) ◽  
pp. 145-151 ◽  
Author(s):  
M-C Boutron ◽  
J Faivre ◽  
P Marteau ◽  
C Couillault ◽  
P Senesse ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dairy Products ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Carcinogenesis ◽  
French Case ◽  
Calcium Phosphorus ◽  
Control Study

scholarly journals The role of Vitamin D Receptor gene polymorphisms in colorectal cancer risk

2019 ◽  
Author(s):  
Ippokratis Messaritakis ◽  
Asimina Koulouridi ◽  
Maria Sfakianaki ◽  
Nikolaos Gouvas ◽  
Elias Athanasakis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Stage Iv ◽  
Colorectal Carcinogenesis ◽  
Vdr Gene ◽  
Kras Mutations ◽  
Receptor Gene Polymorphisms

Abstract Background: Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality. Vitamin D mediates its action through binding of the vitamin D receptor (VDR) and polymorphisms of the VDR might explain these inverse associations. Methods: The aim of the study was the investigation of TaqI, ApaI, FokI and BsmI polymorphisms of the VDR gene for their relevance to colorectal carcinogenesis and progression. Peripheral blood was obtained from 397 patients with early operable stage II/III (n=202) and stage IV (n=195) CRC. Moreover, samples from 100 healthy donors and 40 patients with adenomatous polyps were also included as control groups. Genotyping in samples from patients and controls was performed using PCR-RFLP. Results: A significant association revealed between all four polymorphisms and cancer. Individuals with homozygous mutant (tt, aa, ff or bb) genotype are more susceptible to the disease (p<0.001). All mutant genotypes detected were also significantly associated with the stage IV disease (p<0.001) leading to significantly decreased survival (p<0.001). Moreover, all four polymorphisms were significantly associated with KRAS mutations and with TLR2, TLR4 and TLR9 genetic variants. In multivariate analysis, tt, aa and ff genotypes emerged as independent factors associated with decreased OS (p=0.001, p<0.001 and p=0.001, respectively). Conclusions: The detection of higher frequencies of the VDR polymorphisms in CRC patients highlights the role of these polymorphisms in cancer development and progression.

scholarly journals Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis

2013 ◽  
Vol 136 ◽  
pp. 284-288 ◽  
Author(s):  
Doris Maria Hummel ◽  
Ursula Thiem ◽  
Julia Höbaus ◽  
Ildiko Mesteri ◽  
Lukas Gober ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mouse Model ◽  
Colorectal Carcinogenesis ◽  
Dietary Vitamin ◽  
Preneoplastic Lesions ◽  
Dietary Vitamin D

scholarly journals Association between Vitamin D Receptor Single-Nucleotide Polymorphisms and Colorectal Cancer in the Thai Population: A Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Sirinporn Suksawatamnuay ◽  
Supachaya Sriphoosanaphan ◽  
Prapimphan Aumpansub ◽  
Satimai Aniwan ◽  
Kessarin Thanapirom ◽  
...  
Keyword(s):  
Vitamin D ◽  
Single Nucleotide Polymorphisms ◽  
Vitamin D Receptor ◽  
Colorectal Carcinogenesis ◽  
Nucleotide Polymorphisms ◽  
Control Groups ◽  
Thai Population ◽  
Single Nucleotide ◽  
And Control ◽  
Control Study

Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. A large number of studies demonstrated the association of low vitamin D levels and variations in five common single nucleotide polymorphisms (SNPs), FokI, BsmI, Tru9I, ApaI, and TaqI, with the risk of several cancers, including colorectal cancers. However, these associations vary among different populations. This case-control study was aimed at analysing whether common single-nucleotide polymorphisms (SNPs) and haplotypes of the vitamin D receptor (VDR) gene contribute to colorectal carcinogenesis in the Thai population. We enrolled 364 Thai participants from King Chulalongkorn Memorial Hospital between 2014 and 2015. Half of the participants underwent colonoscopy and showed a normal colon without polyps (control group) and another half were newly diagnosed patients with colorectal cancer (CRC) by colonoscopy during the index period, were under treatment, or were followed up at the outpatient clinic (case group). Differences in allele and genotype frequencies of five common VDR SNPs, between the case and control groups, were the primary outcome measures. Differences in haplotype frequencies of the five SNPs between the case and control groups were the secondary outcome measures. Among the 364 participants, baseline characteristics were not significantly different between the case and control groups, except for the higher proportion of males in the CRC group. The mean vitamin D level was also not significantly different between the case and control groups (24.6±9.1 vs. 25.3±10.6 ng/mL, p=0.52). None of the five VDR SNPs was associated with CRC development (p>0.05). However, haplotype analysis of these polymorphisms demonstrated that the AGGT haplotype was associated with a decreased risk of CRC (odds ratio 0.24, 95% confidence interval 0.07-0.81, p=0.01). The AGGT haplotype was associated with a lower risk of CRC in the Thai population. This genetic linkage might support the role of vitamin D in colorectal carcinogenesis. However, this finding requires further study within a larger population and a multivariate analysis of other established risk factors.

Association of vitamin D receptor genotypes with early onset rheumatoid arthritis

2001 ◽  
Vol 28 (1) ◽  
pp. 89-93 ◽  
Author(s):  
J. R. Garcia-Lozano ◽  
M. F. Gonzalez-Escribano ◽  
A. Valenzuela ◽  
A. Garcia ◽  
A. Nunez-Roldan
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Early Onset
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