scholarly journals Vitamin D and Human Reproduction

10.5772/67394 ◽  
2017 ◽  
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Samira Behboudi-Gandevani
Keyword(s):  
Vitamin D ◽  
Human Reproduction

scholarly journals Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from COVID-19 risk

2021 ◽  
pp. 113-117
Author(s):  
M.S. Bezerra Espinola ◽  
M. Bertelli ◽  
M. Bizzarri
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Pregnant Women ◽  
Assisted Reproductive Technologies ◽  
Respiratory Infections ◽  
Phosphatidyl Inositol ◽  
Reproductive Technologies ◽  
Human Reproduction ◽  
Risk Category ◽  
Virus Species

In late 2019, the new Coronavirus has been identified in the city of Wuhan (China) then COVID-19 spreads like wildfire in the rest of the world. Pregnant women represent a risk category for increased abortion rates and vertical transmission with adverse events on the newborns has been recently confirmed. The scientific world is struggling for finding an effective cure for counteracting symptomatology. Today, there are many therapeutic proposes but none of them can effectively counteract the infection. Moreover, many of these compounds show important side effects not justifying their use. Scientific literature reports an immune system over-reaction through interleukins- 6 activation. In this regard, the possibility to control the immune system represents a possible strategy for counteracting the onset of COVID-19 symptomatology. Vitamin D deficiency shows increased susceptibility to acute viral respiratory infections. Moreover, Vitamin D seems involved in host protection from different virus species by modulating activation and release of cytokines. Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase pathway. Furthermore, myo-inositol is the precursor of phospholipids in the surfactant and it is applied for inducing surfactant synthesis in infants for treating respiratory distress syndrome. This review aims to summarize the evidence about COVID-19 infection in pregnant women and to encourage the scientific community to investigate the use of Vitamin D and Myo-inositol which could represent a possible preventive treatment for pregnant women or women undergoing assisted reproductive technologies.

Vitamin D in human reproduction: a narrative review

2013 ◽  
Vol 67 (3) ◽  
pp. 225-235 ◽  
Author(s):  
Panagiotis Anagnostis ◽  
Spyridon Karras ◽  
Dimitrios G. Goulis
Keyword(s):  
Vitamin D ◽  
Narrative Review ◽  
Human Reproduction

scholarly journals Vitamin D in Follicular Fluid Correlates With the Euploid Status of Blastocysts in a Vitamin D Deficient Population

2021 ◽  
Vol 11 ◽  
Author(s):  
Ana Arnanz ◽  
Neelke De Munck ◽  
Ibrahim El Khatib ◽  
Aşina Bayram ◽  
Andrea Abdala ◽  
...  
Keyword(s):  
Vitamin D ◽  
Follicular Fluid ◽  
Serum Levels ◽  
Human Reproduction ◽  
Serum Samples ◽  
Preimplantation Genetic Testing ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Metabolite Measurement ◽  
Deficient Group

ContextThe widespread distribution of the Vitamin D (VitD) receptor in reproductive tissues suggests an important role for VitD in human reproduction. The assessment of patient´s VitD is based on the 25-hydroxyvitamin D (25(OH)D) metabolite measurement. However, most of the circulating 25(OH)D is bound to either VitD-binding protein (VDBP) (88%) or albumin (12%) and less than 1% circulates free.ObjectiveTo determine a possible correlation between VitD levels in serum (S) and follicular fluid (FF) and blastocyst ploidy status in patients undergoing infertility treatment.MethodsA prospective observational study was performed including couples planned for preimplantation genetic testing for aneuploidies (PGT-A) from ART Fertility Clinics. Patients were classified according to their 25(OH)D-Serum levels: VitD deficient group <20 ng/ml and insufficient/replete ≥20 ng/ml defined as VitD non-deficient group.ResultsSerum samples and 226 FF from individual follicles were collected for 25(OH)D, bioavailable 25(OH)D, free 25(OH)D, and % free 25(OH)D measurement. 25(OH)D-Serum in VitD deficient and non-deficient were 13.2±4.0 ng/ml vs 32.3±9.2 ng/ml; p<0.001. FF from 40 and 74 biopsied blastocysts was analysed of which 52.5 and 60.8% were euploid (p = 0.428), respectively. In VitD deficient patients, mean 25(OH)D-FF, bioavailable 25(OH)D-FF, and free 25(OH)D-FF were higher in euploid vs aneuploid blastocysts (18.3±6.3 ng/ml vs 13.9±4.8 ng/ml; p = 0.040; 1.5±0.5 ng/ml vs 1.1±0.4 ng/ml; p = 0.015; 0.005±0.002 ng/ml vs 0.003±0.001 ng/ml; p = 0.023, respectively), whilst no differences were found in VitD non-deficient patients (37.9±12.3 ng/ml vs 40.6±13.7 ng/ml; p = 0.380; 3.1±1.1 ng/ml vs 3.3±1.2 ng/ml; p = 0.323; 0.01±0.003 ng/ml vs 0.01±0.004 ng/ml; p = 0.319, respectively).ConclusionVitD non-deficient patients have a significantly higher probability of obtaining a euploid blastocyst compared to VitD deficient patients (OR:33.36, p = 0.002).

scholarly journals Vitamin D in human reproduction—an evolving landscape

2016 ◽  
Vol 106 (7) ◽  
pp. 1650-1651 ◽  
Author(s):  
Jason M. Franasiak
Keyword(s):  
Vitamin D ◽  
Human Reproduction

Vitamin D: The secosteroid hormone and human reproduction

2007 ◽  
Vol 23 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Faustino R. Pérez-López
Keyword(s):  
Vitamin D ◽  
Human Reproduction

Is there a role for vitamin D in human reproduction?

2016 ◽  
Vol 25 (1) ◽  
Author(s):  
Anindita Nandi ◽  
Nandita Sinha ◽  
Erwyn Ong ◽  
Halis Sonmez ◽  
Leonid Poretsky
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Human Reproduction ◽  
Bone Modeling ◽  
Metabolizing Enzymes ◽  
Vitro Fertilization ◽  
Vitamin D Levels ◽  
Autoimmune Conditions

AbstractVitamin D is a steroid hormone with canonical roles in calcium metabolism and bone modeling. However, in recent years there has been a growing body of literature presenting associations between vitamin D levels and a variety of disease processes, including metabolic disorders such as diabetes and prediabetes and autoimmune conditions such as thyroid disease. This review focuses on the potential role of vitamin D in both male and female reproductive function. The vitamin D receptor (VDR) is expressed throughout central and peripheral organs of reproduction. VDR is often co-localized with its metabolizing enzymes, suggesting the importance of tissue specific modulation of active vitamin D levels. Both animal and human studies in males links vitamin D deficiency with hypogonadism and decreased fertility. In females, there is evidence for its role in polycystic ovary syndrome (PCOS), endometriosis, leiomyomas, in-vitro fertilization, and pregnancy outcomes. Studies evaluating the effects of replacing vitamin D have shown variable results. There remains some concern that the effects of vitamin D on reproduction are not direct, but rather secondary to the accompanying hypocalcemia or estrogen dysregulation.

scholarly journals Inositol and vitamin D may naturally protect human reproduction and women undergoing assisted reproduction from Covid-19 risk

2021 ◽  
pp. 103271
Author(s):  
Maria Salome Bezerra Espinola ◽  
Matteo Bertelli ◽  
Mariano Bizzarri ◽  
Vittorio Unfer ◽  
Antonio Simone Laganà ◽  
...  
Keyword(s):  
Vitamin D ◽  
Assisted Reproduction ◽  
Human Reproduction

scholarly journals Vitamin D receptor gene polymorphisms and the effectiveness of assisted reproductive technology

2021 ◽  
pp. 360-364
Author(s):  
A. Yu. Romanov ◽  
A. G. Syrkasheva ◽  
A. E. Donnikov ◽  
N. V. Dolgushina
Keyword(s):  
Vitamin D ◽  
Pregnancy Rate ◽  
Assisted Reproduction ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Active Form ◽  
Human Reproduction ◽  
Perivitelline Space ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms

Introduction. Vitamin D administration is recommended for women with vitamin D insufficiency, who are planning to undergo assisted reproductive treatment (ART). The action of the active form of vitamin D is mediated through its vitamin D receptor (VDR). The presence of VDR in the cells and tissues of the female reproductive system suggests that vitamin D plays an important role in human reproduction. However, the effect of VDR gene polymorphisms on human reproduction has not been adequately studied.Aim. To assess the effect of VDR gene polymorphisms on the folliculogenesis, embryogenesis and clinical outcomes of assisted reproduction programs.Materials and methods. The cross-sectional study included 300 patients without complications during the assisted reproduction cycle. The number of follicles, oocyte-cumulus complexes, mature and immature oocytes, the presence of oocyte dysmorphisms, number of zygotes, fertilization rate, and the number of obtained blastocysts were evaluated. The determination of three polymorphisms of the VDR gene (FokI – rs2228570, BsmI – rs1544410, TaqI – rs731236) was performed by real-time polymerase chain reaction.Results. The incidence of perivitelline space pathology of oocytes in FokI A/A genotype patients was 5.7%, in A/G genotype patients  – 14.7%, in  G/G genotype patients  – 16.3% (p  =  0.041  when comparing A/A  genotype with A/G + G/G genotypes). Depending on the genotype, the pregnancy rate ranged from 38.5 to 52.8%, but no statistically significant differences were found.Conclusion. It was shown that the perivitelline space pathology of oocytes in the FokI A/G genotype patients is 2.6 times higher, and in the G/G genotype patients – 2.9 times higher than in the A/A genotype patients. However, there were no differences in pregnancy rate among patients with different genotypes of FokI, BsmI and TaqI gene polymorphisms of VDR. 

scholarly journals The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1567
Author(s):  
Irene Moridi ◽  
Alice Chen ◽  
Oded Tal ◽  
Reshef Tal
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Ovarian Reserve ◽  
Potential Benefit ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Human Reproduction ◽  
Female Reproduction ◽  
The Relationship

Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

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