scholarly journals Long-Term Survivors of Childhood Cancer: The Late Effects of Therapy

10.5772/67366 ◽  
2017 ◽  
Author(s):  
Nupur Mittal ◽  
Paul Kent
Keyword(s):  
Childhood Cancer ◽  
Late Effects ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

scholarly journals No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment

Cancer ◽  
2018 ◽  
Vol 124 (17) ◽  
pp. 3576-3585 ◽  
Author(s):  
Fabiën N. Belle ◽  
Rahel Kasteler ◽  
Christina Schindera ◽  
Murielle Bochud ◽  
Roland A. Ammann ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Glucocorticoid Treatment ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Abstract 5949: Abnormal NT-Pro-BNP Levels in Asymptomatic Long Term Survivors of Childhood Cancer Treated with Anthracyclines

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Annelies M Mavinkurve-Groothuis ◽  
Jacqueline Groot-Loonen ◽  
Louise Bellersen ◽  
Milanthy S Pourier ◽  
Ton Feuth ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Late Onset ◽  
Troponin T ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Internal Diameter ◽  
List Type ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Objectives : to document plasma concentrations of cardiac Troponin T (cTnT) and NT-pro-brain natriuretic peptide (NT-pro-BNP) in a large group of asymptomatic long term survivors of childhood cancer treated with anthracyclines, to study the relation of the abnormal biomarker levels with different risk factors for anthracycline-induced cardiotoxicity and conventional echocardiographic parameters. Methods : 122 asymptomatic survivors of childhood cancer underwent a detailed echocardiography. Blood samples were taken to determine the levels of NT-pro-BNP and cTnT. Results : None of the survivors had abnormal cTnT levels. The mean NT-pro-BNP level of our survivor group was 10 pmol/l (SD±9) with a range of 1–55 pmol/l. Thirteen percent of the survivors had abnormal NT-pro-BNP levels. Abnormal NT-pro-BNP levels were significantly related to cumulative anthracycline dosage (p<0.003). Eleven of 31 (35%) survivors treated with cumulative anthracycline dose of 300 mg/m 2 or more, had abnormal NT-pro-BNP levels which were significantly related to end-diastolic left ventricular internal diameter (LVIDd) indexed for body surface area (BSA) (p<0.01). Conclusion : Cardiac TnT does not contribute to the early detection of late onset anthracyline-induced cardiotoxicity. Abnormal levels of NT-pro-BNP were frequently detected in asymptomatic, long term survivors of childhood cancer. Follow up of these survivors, with both echocardiography and NT-pro-BNP, is essential to answer the question whether NT-pro-BNP is an early marker for late onset anthracycline-induced cardiotoxicity.

Neuropsychological Late Effects

2006 ◽  
Author(s):  
Raymond K. Mulhern ◽  
Robert W. Butler
Keyword(s):  
Brain Tumors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Lymphoblastic Leukemia ◽  
Future Research ◽  
Cognitive Changes ◽  
Neuropsychological Status ◽  
Neurobiological Substrates ◽  
Long Term Survivors

This chapter reviews neuropsychological late effects associated with childhood cancer and its treatment. The study of late effects presupposes that patients are long-term survivors, if not permanently cured, of their disease. Late effects are temporally defined as occurring after the successful completion of medical therapy, usually 2 or more years from the time of diagnosis, and it is generally assumed that late effects are chronic, if not progressive, in their course. This definition serves to separate late effects from those effects of disease and treatment that are acute or subacute and time limited, such as chemotherapy-induced nausea and vomiting or temporary cognitive changes induced by cancer therapy. Research interest in neuropsychological outcomes, as well as neurological and other functional late effects, has shown an increase commensurate with improvements in effective therapy. For example, 30 years ago when few children were cured of acute lymphoblastic leukemia (ALL), questions related to the ultimate academic or vocational performance of long-term survivors were trivial compared to the need for improved therapy. In contrast, today more than 80% of children diagnosed with ALL can be cured, and issues related to their quality of life as long-term survivors have now received increased emphasis. There is at least comparable attention to neuropsychological status in primary brain tumors. We first provide a brief medical background on the two most frequent forms of childhood cancer, ALL and malignant brain tumors, followed by a review of the current neuropsychological literature. The literature review provides an in-depth analysis of the types of cognitive impairments observed and known or suspected risk factors for impairments. When neurobiological substrates are known, particularly from neuroimaging studies, they are discussed. Finally, we conclude the review with sections that discuss current recommendations for a core battery of neuropsychological assessment of survivors and recommendations for future research. Approximately 20,000 children and adolescents under the age of 20 years were diagnosed with cancer in 1999 (Steen & Mirro, 2000). The most commonly diagnosed cancer in this age group is ALL, a malignant disorder of lymphoid cells found in the bone marrow that migrates to virtually every organ system, including the central nervous system (CNS), via the circulatory system. ALL accounts for one fourth of all childhood cancers and 75% of all cases of childhood leukemia (Margolin, Steuber, & Poplack, 2002).

scholarly journals Diabetes Mellitus in Long-term Survivors of Childhood Cancer

2009 ◽  
Vol 169 (15) ◽  
pp. 1381 ◽  
Author(s):  
Lillian R. Meacham ◽  
Charles A. Sklar ◽  
Suwen Li ◽  
Qi Liu ◽  
Nora Gimpel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Childhood Cancer ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors
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