scholarly journals Coronary Collateral Growth: Clinical Perspectives and Recent Insights

10.5772/67164 ◽  
2017 ◽  
Author(s):  
Bhamini Patel ◽  
Peter Hopmann ◽  
Mansee Desai ◽  
Kanithra Sekaran ◽  
Kathleen Graham ◽  
...  
Keyword(s):  
Coronary Collateral ◽  
Collateral Growth ◽  
Coronary Collateral Growth

scholarly journals Sprouting Angiogenesis Contributes to Coronary Collateral Growth Induced by Repetitive Ischemia in Adult Mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Anurag Jamaiyar ◽  
Cody Juguilon ◽  
Devan Richardson ◽  
James Gadd ◽  
Tao Wang ◽  
...  
Keyword(s):  
Sprouting Angiogenesis ◽  
Coronary Collateral ◽  
Adult Mice ◽  
Collateral Growth ◽  
Coronary Collateral Growth

Abstract 592: Cardioprotection During Ischemia by Induced Coronary Collateral Growth

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Anurag Jamaiyar ◽  
Cody Juguilon ◽  
Devan Cumpston ◽  
Weiguo Wan ◽  
Tao Wang ◽  
...  
Keyword(s):  
Coronary Collateral ◽  
Collateral Growth ◽  
Coronary Collateral Growth

scholarly journals MMPs 2 and 9 are essential for coronary collateral growth and are prominently regulated by p38 MAPK

2011 ◽  
Vol 51 (6) ◽  
pp. 1015-1025 ◽  
Author(s):  
Tracy Dodd ◽  
Rashmi Jadhav ◽  
Luke Wiggins ◽  
James Stewart ◽  
Erika Smith ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Coronary Collateral ◽  
Collateral Growth ◽  
Coronary Collateral Growth

scholarly journals miR-21-mediated decreased neutrophil apoptosis is a determinant of impaired coronary collateral growth in metabolic syndrome

2015 ◽  
Vol 308 (11) ◽  
pp. H1323-H1335 ◽  
Author(s):  
Rebecca Hutcheson ◽  
Russell Terry ◽  
Brenda Hutcheson ◽  
Rashmi Jadhav ◽  
Jennifer Chaplin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Cytochrome C ◽  
Stress Generation ◽  
Neutrophil Apoptosis ◽  
Cytochrome C Release ◽  
Coronary Collateral ◽  
Sd Rats ◽  
Collateral Growth ◽  
Coronary Collateral Growth

Coronary collateral growth (CCG) is impaired in metabolic syndrome. microRNA-21 (miR-21) is a proproliferative and antiapoptotic miR, which we showed to be elevated in metabolic syndrome. Here we investigate whether impaired CCG in metabolic syndrome involved miR-21-mediated aberrant apoptosis. Normal Sprague-Dawley (SD) and metabolic syndrome [J. C. Russel (JCR)] rats underwent transient, repetitive coronary artery occlusion [repetitive ischemia (RI)]. Antiapoptotic Bcl-2, phospho-Bad, and Bcl-2/Bax dimers were increased on days 6 and 9 RI, and proapoptotic Bax and Bax/Bax dimers and cytochrome- c release concurrently decreased in JCR versus SD rats. Active caspases were decreased in JCR versus SD rats (∼50%). Neutrophils increased transiently on day 3 RI in the collateral-dependent zone of SD rats but remained elevated in JCR rats, paralleling miR-21 expression. miR-21 downregulation by anti-miR-21 induced neutrophil apoptosis and decreased Bcl-2 and Bcl-2/Bax dimers (∼75%) while increasing Bax/Bax dimers, cytochrome- c release, and caspase activation (∼70, 400, and 400%). Anti-miR-21 also improved CCG in JCR rats (∼60%). Preventing neutrophil infiltration with blocking antibodies resulted in equivalent CCG recovery, confirming a major role for deregulated neutrophil apoptosis in CCG impairment. Neutrophil and miR-21-dependent CCG inhibition was in significant part mediated by increased oxidative stress. We conclude that neutrophil apoptosis is integral to normal CCG and that inappropriate prolonged miR-21-mediated survival of neutrophils plays a major role in impaired CCG, in part via oxidative stress generation.

scholarly journals Ischemia-Induced Coronary Collateral Growth Is Dependent on Vascular Endothelial Growth Factor and Nitric Oxide

Circulation ◽  
2000 ◽  
Vol 102 (25) ◽  
pp. 3098-3103 ◽  
Author(s):  
Toshiro Matsunaga ◽  
David C. Warltier ◽  
Dorothee W. Weihrauch ◽  
Melinda Moniz ◽  
John Tessmer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Coronary Collateral ◽  
Collateral Growth ◽  
Coronary Collateral Growth ◽  
Endothelial Growth Factor

scholarly journals Stimulation of Coronary Collateral Growth by Granulocyte Stimulating Factor

2009 ◽  
Vol 29 (11) ◽  
pp. 1817-1822 ◽  
Author(s):  
Ana Catarina R. Carrão ◽  
William M. Chilian ◽  
June Yun ◽  
Christopher Kolz ◽  
Petra Rocic ◽  
...  
Keyword(s):  
Coronary Collateral ◽  
Collateral Growth ◽  
Coronary Collateral Growth ◽  
Stimulating Factor ◽  
Stimulation Of
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