scholarly journals Coexistence of the Aortic Aneurysm with the Main Vein Anomalies: Its Potential Clinical Implications and Vascular Complication

10.5772/66768 ◽  
2017 ◽  
Author(s):  
Michal Polguj ◽  
Katarzyna Stefanczyk ◽  
Ludomir Stefanczyk
Keyword(s):  
Aortic Aneurysm ◽  
Vascular Complication ◽  
Clinical Implications ◽  
Main Vein

Abstract 12726: Crucial Role of Jak2 V617f-positive Myeloproliferative Neoplasm in the Development of Aortic Aneurysm

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Tetsuro Yokokawa ◽  
Tomofumi Misaka ◽  
Yusuke KIMISHIMA ◽  
Kento Wada ◽  
Keiji Minakawa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Angiotensin Ii ◽  
Aortic Aneurysm ◽  
Mrna Expression ◽  
Abdominal Aorta ◽  
Myeloproliferative Neoplasms ◽  
Myeloproliferative Neoplasm ◽  
Jak2 V617f ◽  
Vascular Complication ◽  
The Impact

Objective: To investigate the impact of hematopoietic JAK2V617F, which causes myeloproliferative neoplasms (MPNs), on the development of aortic aneurysm (AA). Approach and Results: We applied a bone marrow transplantation (BMT) strategy using the donor cells from Jak2 V617F transgenic (JAK2 V617F ) mice into the lethally irradiated apolipoprotein E-deficient mice. To induce the AA formation and progression, the recipient mice (BMT mice) were subjected to continuous angiotensin II infusion. Abdominal aortic diameter in JAK2 V617F -BMT mice was significantly enlarged compared to the control wild-type (WT)-BMT mice in response to angiotensin II. The incidence of abdominal AA was significantly higher in JAK2 V617F -BMT mice than in WT-BMT mice. Hematopoietic JAK2V617F accelerated aortic elastic lamina degradation as well as activation of matrix metalloproteinase (MMP)-2 and MMP-9 in the abdominal aorta. The numbers of CD68 + macrophages and Ly6B.2 + neutrophils and cytokine expressions such as Ccl6 and Tgfb1 were significantly increased in the abdominal aorta of JAK2 V617F -BMT mice accompanied by STAT3 activation. Bone marrow-derived macrophages carrying JAK2V617F showed elevations of both Mmp2 and Mmp9 mRNA expression. Finally, we found that 23% of MPN patients with JAK2 V617F mutation showed the presence of AA and increases in TGFB3 and IL-8 mRNA expression of the peripheral leukocytes. Conclusions: Hematopoietic JAK2V617F was involved in the development of AA through increases in the infiltration of inflammatory cells and MMP activation. Our findings provide a novel feature of vascular complication of AA in MPNs due to constitutive activation of the hematopoietic JAK-STAT pathway.

scholarly journals Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications

Aorta ◽  
2019 ◽  
Vol 07 (04) ◽  
pp. 099-107 ◽  
Author(s):  
Thais Faggion Vinholo ◽  
Adam J. Brownstein ◽  
Bulat A. Ziganshin ◽  
Mohammad A. Zafar ◽  
Helena Kuivaniemi ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Natural History ◽  
Molecular Genetics ◽  
Thoracic Aortic Aneurysm ◽  
Surgical Intervention ◽  
Pathogenic Mutation ◽  
Clinical Implications ◽  
Aortic Aneurysm And Dissection

AbstractThoracic aortic aneurysm is a typically silent disease characterized by a lethal natural history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection (TAAD) almost 2 decades ago, our understanding of the genetics of this disorder has undergone a transformative amplification. To date, at least 37 TAAD-causing genes have been identified and an estimated 30% of the patients with familial nonsyndromic TAAD harbor a pathogenic mutation in one of these genes. In this review, we present our yearly update summarizing the genes associated with TAAD and the ensuing clinical implications for surgical intervention. Molecular genetics will continue to bolster this burgeoning catalog of culprit genes, enabling the provision of personalized aortic care.

Models of Abdominal Aortic Aneurysm: Characterization and Clinical Applications

Vascular ◽  
2006 ◽  
Vol 14 (6) ◽  
pp. 343-352 ◽  
Author(s):  
Rabih A. Chaer ◽  
Brian G. DeRubertis ◽  
Robert Hynecek ◽  
K. Craig Kent ◽  
Peter L. Faries
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Animal Models ◽  
Aortic Aneurysm ◽  
Abdominal Aortic Aneurysms ◽  
Clinical Applications ◽  
Aortic Aneurysms ◽  
Clinical Implications ◽  
Scientific Assessment ◽  
Abdominal Aortic ◽  
Considerable Morbidity

Abdominal aortic aneurysms (AAAs) are responsible for considerable morbidity, mortality, and cost to society. The pathogenesis of AAA formation, however, remains poorly understood. Animal models have been used in a range of experiments designed to provide further objective scientific assessment of the pathogenesis as well as the treatment of AAA. The purpose of this manuscript is to review the current models of AAA and their potential clinical implications.

scholarly journals Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications

Aorta ◽  
2018 ◽  
Vol 06 (01) ◽  
pp. 013-020 ◽  
Author(s):  
Adam Brownstein ◽  
Valentyna Kostiuk ◽  
Bulat Ziganshin ◽  
Mohammad Zafar ◽  
Helena Kuivaniemi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Aortic Aneurysm ◽  
General Population ◽  
Thoracic Aortic Aneurysm ◽  
Pathogenic Mutation ◽  
Aortic Aneurysms ◽  
Clinical Implications ◽  
Thoracic Aortic Aneurysms ◽  
Exponential Increase ◽  
Aortic Aneurysm And Dissection

AbstractThoracic aortic aneurysms, with an estimated prevalence in the general population of 1%, are potentially lethal, via rupture or dissection. Over the prior two decades, there has been an exponential increase in our understanding of the genetics of thoracic aortic aneurysm and/or dissection (TAAD). To date, 30 genes have been shown to be associated with the development of TAAD and ∼30% of individuals with nonsyndromic familial TAAD have a pathogenic mutation in one of these genes. This review represents the authors' yearly update summarizing the genes associated with TAAD, including implications for the surgical treatment of TAAD. Molecular genetics will continue to revolutionize the approach to patients afflicted with this devastating disease, permitting the application of genetically personalized aortic care.

scholarly journals Mycotic Aortic Aneurysm and Infected Aortic Graft After Intravesical Bacillus Calmette-Guérin Treatment for Bladder Cancer

2018 ◽  
Vol 53 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Fabien Lareyre ◽  
Julie Reverso-Meinietti ◽  
Joseph Carboni ◽  
Alice Gaudart ◽  
Réda Hassen-Khodja ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Aortic Aneurysm ◽  
Current Knowledge ◽  
Early Stage ◽  
Graft Infection ◽  
Infectious Complications ◽  
Vascular Complication ◽  
Intravesical Therapy ◽  
Bacillus Calmette Guerin ◽  
Aortic Graft

Although intravesical therapy with bacillus Calmette-Guérin (BCG) has proven its efficiency in the treatment of early-stage bladder cancer, infectious complications can occur and mycotic aneurysms represent a rare but life-threatening complication. Here, we report the case of an aortic graft infection in a patient with abdominal aortic aneurysm who received BCG instillations for the treatment of bladder cancer. Based on the current knowledge on this rare vascular complication, we discuss factors that may have contributed to its occurrence and review issues to optimize its management and early detection.

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

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