scholarly journals VEGF-Mediated Signal Transduction in Tumor Angiogenesis

10.5772/66764 ◽  
2017 ◽  
Author(s):  
Lucia Napione ◽  
Maria Alvaro ◽  
Federico Bussolino
Keyword(s):  
Signal Transduction ◽  
Tumor Angiogenesis

scholarly journals Signal transduction in tumor angiogenesis

2015 ◽  
pp. 861-871
Author(s):  
Timothy Hla ◽  
Nasser Altorki ◽  
Vivek Mittal
Keyword(s):  
Signal Transduction ◽  
Tumor Angiogenesis

Ultrastructural aspects of olfactory signal transduction and its development

1994 ◽  
Vol 52 ◽  
pp. 142-143
Author(s):  
Bert Ph. M. Menco
Keyword(s):  
Signal Transduction ◽  
Olfactory Receptor ◽  
Receptor Cell ◽  
Freeze Substitution ◽  
Luminal Surface ◽  
Tissue Sections ◽  
Olfactory Receptor Cells ◽  
Receptor Cells ◽  
Olfactory Signal ◽  
Odor Molecule

Vertebrate olfactory receptor cells are specialized neurons that have numerous long tapering cilia. The distal parts of these cilia line the interface between the external odorous environment and the luminal surface of the olfactory epithelium. The length and number of these cilia results in a large surface area that presumably increases the chance that an odor molecule will meet a receptor cell. Advanced methods of cryoprepration and immuno-gold labeling were particularly useful to preserve the delicate ultrastructural and immunocytochemical features of olfactory cilia required for localization of molecules involved in olfactory signal-transduction. We subjected olfactory tissues to freeze-substitution in acetone (unfixed tissues) or methanol (fixed tissues) followed by low temperature embedding in Lowicryl K11M for that purpose. Tissue sections were immunoreacted with several antibodies against proteins that are presumably important in olfactory signal-transduction.

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

Signal-regulated oxidation of proteins via MICAL

2020 ◽  
Vol 48 (2) ◽  
pp. 613-620
Author(s):  
Clara Ortegón Salas ◽  
Katharina Schneider ◽  
Christopher Horst Lillig ◽  
Manuela Gellert
Keyword(s):  
Signal Transduction ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Redox Regulation ◽  
Signal Transduction Pathways ◽  
Cellular Functions ◽  
Intracellular Signals ◽  
Amino Acid Side Chains ◽  
Specific Receptors ◽  
Sulfur Containing

Processing of and responding to various signals is an essential cellular function that influences survival, homeostasis, development, and cell death. Extra- or intracellular signals are perceived via specific receptors and transduced in a particular signalling pathway that results in a precise response. Reversible post-translational redox modifications of cysteinyl and methionyl residues have been characterised in countless signal transduction pathways. Due to the low reactivity of most sulfur-containing amino acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail before, the discovery and characterisation of MICAL proteins evinced the first examples of specific oxidases in signal transduction. This article provides an overview of the functions of MICAL proteins in the redox regulation of cellular functions.

Specificity of receptor-mediated signal transduction by E. coli type its heat-labile toxin

2001 ◽  
Vol 120 (5) ◽  
pp. A700-A700
Author(s):  
S WIMERMACKIN ◽  
R HOLMES ◽  
A WOLF ◽  
W LENCER ◽  
M JOBLING
Keyword(s):  
Signal Transduction ◽  
E Coli ◽  
Heat Labile

Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus

2001 ◽  
Vol 120 (5) ◽  
pp. A296-A296
Author(s):  
C DAI ◽  
G STEVENL ◽  
M GEE ◽  
W LEE ◽  
H LEE ◽  
...  
Keyword(s):  
Tumor Angiogenesis ◽  
Colon Tumor ◽  
Mouse Colon

149: The Effect of Denervation on Signal Transduction Mechanisms of M2 and M3 Mediated Bladder Contractile Response

2005 ◽  
Vol 173 (4S) ◽  
pp. 40-40
Author(s):  
Leo R. Doumanian ◽  
Alan S. Braverman ◽  
Amitt S. Tibb ◽  
Michael R. Ruggieri
Keyword(s):  
Signal Transduction ◽  
Contractile Response ◽  
Transduction Mechanisms
Sign in / Sign up

Export Citation Format

Share Document