scholarly journals Mechanism of Hair Loss from the Point of View of Epidermal Cell Polarity

10.5772/66735 ◽  
2017 ◽  
Author(s):  
Shin-Ichi Osada
Keyword(s):  
Cell Polarity ◽  
Epidermal Cell ◽  
Hair Loss ◽  
Point Of View

scholarly journals Pharmaceutico-Analytical study of Karanjadi Taila and its conversion into cream

2020 ◽  
Vol 5 (05) ◽  
pp. 245-249
Author(s):  
Sachin S. Sheth ◽  
Gangaprasad R. Asore ◽  
Kiran Sudhakar Darade
Keyword(s):  
Present Article ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Analytical Study ◽  
Chief Complaint ◽  
Point Of View ◽  
Special Importance ◽  
Analytical Results

Karanjadi Taila is medicated oil used in Ayurveda for Indralupta (Alopecia). Indralupta comes under Kshudra Roga which is characterized by loss of hair it can be correlated with Alopecia areata which is having chief complaint of hair loss on body especially on scalp. The aim of the present study is to do physic-chemical standards for the above Taila and its conversion into Karanjadi Taila cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Tailas or cream. In present article, we are trying to study analytical results of Karanjadi Taila w.s.r. to Karanjadi Taila cream.

scholarly journals Regions within a single epidermal cell of Drosophila can be planar polarised independently

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Miguel Rovira ◽  
Pedro Saavedra ◽  
José Casal ◽  
Peter A Lawrence
Keyword(s):  
Single Cell ◽  
Larval Development ◽  
Cell Polarity ◽  
Epidermal Cell ◽  
Planar Cell Polarity ◽  
Different Types ◽  
Local Comparison ◽  
Epithelial Sheets

Planar cell polarity (PCP), the coordinated and consistent orientation of cells in the plane of epithelial sheets, is a fundamental and conserved property of animals and plants. Up to now, the smallest unit expressing PCP has been considered to be an entire single cell. We report that, in the larval epidermis of Drosophila, different subdomains of one cell can have opposite polarities. In larvae, PCP is driven by the Dachsous/Fat system; we show that the polarity of a subdomain within one cell is its response to levels of Dachsous/Fat in the membranes of contacting cells. During larval development, cells rearrange (<xref ref-type="bibr" rid="bib25">Saavedra et al., 2014</xref>) and when two subdomains of a single cell have different types of neighbouring cells, then these subdomains can become polarised in opposite directions. We conclude that polarisation depends on a local comparison of the amounts of Dachsous and Fat within opposing regions of a cell's membrane.

scholarly journals Barley disease susceptibility factor RACB acts in epidermal cell polarity and positioning of the nucleus

2016 ◽  
Vol 67 (11) ◽  
pp. 3263-3275 ◽  
Author(s):  
Björn Scheler ◽  
Vera Schnepf ◽  
Carolina Galgenmüller ◽  
Stefanie Ranf ◽  
Ralph Hückelhoven
Keyword(s):  
Cell Polarity ◽  
Epidermal Cell ◽  
Disease Susceptibility ◽  
Susceptibility Factor

scholarly journals Antiandrogenic therapy with ciproterone acetate in female patients who suffer from both androgenetic alopecia and acne vulgaris

2014 ◽  
Vol 87 (4) ◽  
pp. 226-234 ◽  
Author(s):  
Andrei Coneac ◽  
Adriana Muresan ◽  
Meda Sandra Orasan
Keyword(s):  
Hair Loss ◽  
Ethinyl Estradiol ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Point Of View ◽  
Androgenetic Alopecia ◽  
Oil Glands ◽  
Clinical Criteria ◽  
Severe Acne ◽  
Antiandrogenic Therapy

Background. Androgenetic Alopecia in Women (AGA) occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization, caused by androgens. Clinically, AGA is characterized by progressive hair loss, with a marked hair thinning in the fronto-parietal area so that the scalp can be easily seen. Acne vulgaris is androgen-dependent and often affects the skin that has an increased number of oil glands: face, back and chest. Although the sebaceous glands are present on the scalp too, it is very rare to get acne at this site, as the hair acts as a wig and allows the sebum to drain and does not block the pores. Both AGA and Acne Vulgaris are signs of hyperandrogenism. Cyproterone acetate/ethinyl estradiol (2mg/0.035mg) products are authorized for the treatment of androgenetic symptoms in women, such as acne, seborrhea, mild forms of hirsutism and androgenetic alopecia. Our study had a double purpose: - To evaluate the result of the study regimen Melleva 35 (one pill per day, for 3 consecutive months) in patients with moderate to severe acne, suffering also from Androgenetic Alopecia; - To establish the efficacy of the drug on acne and alopecia improvement, both from the doctor’s and patient’s point of view. Patients and methods. After being informed of the aims and procedures of the study, participants provided a written informed consent. A number of 35 female subjects with moderate to severe acne vulgaris remained in the study. The subjects had also been diagnosed as suffering from AGA, on the basis of clinical criteria, including the pattern of hair loss and trichoscopy assessment. Results. 83% of study subjects reported that their hair did not continue to fall after 3 months of antiandrogen therapy. The females were evaluated using trichoscopy and the doctor noticed hair regrowth in 77% of the cases. Regarding the improvement of acne lesions after the treatment, 40% of study subjects recorded good improvement and 26% recorded excellent results with Melleva 35. The acceptance of the treatment was very high, 86% patients were compliant with the study therapy. The rate of adverse events (5 cases) was within the limits of the treatment tested by the study. Almost a third of the total number of subjects (28.5%) reached a good satisfaction level after the treatment, while 37.1% claimed moderate satisfaction. Conclusion. There was no correlation between the age of the subjects and the treatment for acne therefore our first hypothesis was rejected. As a conclusion, antiandrogenic therapy with Melleva 35, 1 pill per day, for 3 consecutive months, shows good results for patients who suffer from both Androgenetic Alopecia and Acne Vulgaris.

scholarly journals Three cases of hair loss analyzed by the point of view of the analytical psychology

2017 ◽  
Vol 9 (4) ◽  
pp. 177
Author(s):  
AdemirCarvalho Leite Júnior ◽  
Tatiele Katzer ◽  
DeniseGimenez Ramos
Keyword(s):  
Hair Loss ◽  
Analytical Psychology ◽  
Point Of View

scholarly journals Type XVII collagen interacts with the aPKC‐PAR complex and maintains epidermal cell polarity

2020 ◽  
Vol 30 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Mika Watanabe ◽  
Hideyuki Kosumi ◽  
Shin‐Ichi Osada ◽  
Shota Takashima ◽  
Yunan Wang ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Epidermal Cell ◽  
Xvii Collagen

scholarly journals Plasticity of both planar cell polarity and cell identity during the development of Drosophila

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Pedro Saavedra ◽  
Jean-Paul Vincent ◽  
Isabel M Palacios ◽  
Peter A Lawrence ◽  
José Casal
Keyword(s):  
Pattern Formation ◽  
Cell Polarity ◽  
Epidermal Cell ◽  
Larval Stage ◽  
Planar Cell Polarity ◽  
Single Cells ◽  
Larval Growth ◽  
Larval Stages ◽  
Larval Moult ◽  
Genetic Mechanisms

Drosophila has helped us understand the genetic mechanisms of pattern formation. Particularly useful have been those organs in which different cell identities and polarities are displayed cell by cell in the cuticle and epidermis (<xref ref-type="bibr" rid="bib27">Lawrence, 1992</xref>; <xref ref-type="bibr" rid="bib5">Bejsovec and Wieschaus, 1993</xref>; <xref ref-type="bibr" rid="bib17">Freeman, 1997</xref>). Here we use the pattern of larval denticles and muscle attachments and ask how this pattern is maintained and renewed over the larval moult cycles. During larval growth each epidermal cell increases manyfold in size but neither divides nor dies. We follow individuals from moult to moult, tracking marked cells and find that, as cells are repositioned and alter their neighbours, their identities change to compensate and the pattern is conserved. Single cells adopting a new fate may even acquire a new polarity: an identified cell that makes a forward-pointing denticle in the first larval stage may make a backward-pointing denticle in the second and third larval stages.

The Geosciences Applied to Lunar Exploration

1962 ◽  
Vol 14 ◽  
pp. 169-257 ◽  
Author(s):  
J. Green
Keyword(s):  
Lunar Surface ◽  
Probable Mechanism ◽  
Point Of View ◽  
Lunar Exploration ◽  
Geological Model ◽  
Apply Geophysics ◽  
Surface Features ◽  
The Impact

The term geo-sciences has been used here to include the disciplines geology, geophysics and geochemistry. However, in order to apply geophysics and geochemistry effectively one must begin with a geological model. Therefore, the science of geology should be used as the basis for lunar exploration. From an astronomical point of view, a lunar terrain heavily impacted with meteors appears the more reasonable; although from a geological standpoint, volcanism seems the more probable mechanism. A surface liberally marked with volcanic features has been advocated by such geologists as Bülow, Dana, Suess, von Wolff, Shaler, Spurr, and Kuno. In this paper, both the impact and volcanic hypotheses are considered in the application of the geo-sciences to manned lunar exploration. However, more emphasis is placed on the volcanic, or more correctly the defluidization, hypothesis to account for lunar surface features.

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