scholarly journals Analysis of 10086 Microarray Gene Expression Data Uncovers Genes that Subclassify Breast Cancer Intrinsic Subtypes

10.5772/66161 ◽  
2017 ◽  
Author(s):  
I-Hsuan Lin ◽  
Ming-Ta Hsu
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Gene Expression Data ◽  
Microarray Gene Expression Data ◽  
Expression Data ◽  
Intrinsic Subtypes ◽  
Microarray Gene Expression ◽  
Microarray Gene

scholarly journals Feature Selection and Classification of MAQC-II Breast Cancer and Multiple Myeloma Microarray Gene Expression Data

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8250 ◽  
Author(s):  
Qingzhong Liu ◽  
Andrew H. Sung ◽  
Zhongxue Chen ◽  
Jianzhong Liu ◽  
Xudong Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Multiple Myeloma ◽  
Feature Selection ◽  
Gene Expression Data ◽  
Microarray Gene Expression Data ◽  
Expression Data ◽  
Microarray Gene Expression ◽  
Microarray Gene

Cox Survival Analysis of Microarray Gene Expression Data Using Correlation Principal Component Regression

2007 ◽  
Vol 6 (1) ◽  
Author(s):  
Qiang Zhao ◽  
Jianguo Sun
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Principal Component Regression ◽  
Predictive Ability ◽  
Principal Component ◽  
Microarray Gene Expression Data ◽  
Expression Data ◽  
Microarray Gene Expression ◽  
New Approach ◽  
Microarray Gene

Statistical analysis of microarray gene expression data has recently attracted a great deal of attention. One problem of interest is to relate genes to survival outcomes of patients with the purpose of building regression models for the prediction of future patients' survival based on their gene expression data. For this, several authors have discussed the use of the proportional hazards or Cox model after reducing the dimension of the gene expression data. This paper presents a new approach to conduct the Cox survival analysis of microarray gene expression data with the focus on models' predictive ability. The method modifies the correlation principal component regression (Sun, 1995) to handle the censoring problem of survival data. The results based on simulated data and a set of publicly available data on diffuse large B-cell lymphoma show that the proposed method works well in terms of models' robustness and predictive ability in comparison with some existing partial least squares approaches. Also, the new approach is simpler and easy to implement.

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