scholarly journals Identification and Validation of Novel Drug Targets for the Treatment of Plasmodium falciparum Malaria: New Insights

10.5772/65659 ◽  
2016 ◽  
Author(s):  
Sergey Lunev ◽  
Fernando A. Batista ◽  
Soraya S. Bosch ◽  
Carsten Wrenger ◽  
Matthew R. Groves
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Drug Targets ◽  
Plasmodium Falciparum Malaria ◽  
Novel Drug ◽  
Novel Drug Targets

An in silico strategy for identification of novel drug targets against Plasmodium falciparum

2017 ◽  
Vol 116 (9) ◽  
pp. 2539-2559 ◽  
Author(s):  
Subhashree Rout ◽  
Namrata Priyadarshini Patra ◽  
Rajani Kanta Mahapatra
Keyword(s):  
Plasmodium Falciparum ◽  
In Silico ◽  
Drug Targets ◽  
Novel Drug ◽  
Novel Drug Targets

scholarly journals Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Silvio Paone ◽  
Sarah D’Alessandro ◽  
Silvia Parapini ◽  
Francesco Celani ◽  
Valentina Tirelli ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Host Cell ◽  
Drug Targets ◽  
Parasitophorous Vacuole ◽  
Erythrocyte Invasion ◽  
Inhibitory Compounds ◽  
Novel Drug ◽  
Novel Drug Targets

AbstractMalaria is still a devastating disease with 228 million cases globally and 405,000 lethal outcomes in 2018, mainly in children under five years of age. The threat of emerging malaria strains resistant to currently available drugs has made the search for novel drug targets compelling. The process by which Plasmodium falciparum parasites invade the host cell has been widely studied, but only a few erythrocyte proteins involved in this process have been identified so far. The erythrocyte protein Rac1 is a GTPase that plays an important role in host cell invasion by many intracellular pathogens. Here we show that Rac1 is recruited in proximity to the site of parasite entry during P. falciparum invasion process and that subsequently localizes to the parasitophorous vacuole membrane. We also suggest that this GTPase may be involved in erythrocyte invasion by P. falciparum, by testing the effect of specific Rac1 inhibitory compounds. Finally, we suggest a secondary role of the erythrocyte GTPase also in parasite intracellular development. We here characterize a new erythrocyte protein potentially involved in P. falciparum invasion of the host cell and propose the human GTPase Rac1 as a novel and promising antimalarial drug target.

Novel drug targets in 2019

2020 ◽  
Vol 19 (5) ◽  
pp. 300-300 ◽  
Author(s):  
Sorin Avram ◽  
Liliana Halip ◽  
Ramona Curpan ◽  
Tudor I. Oprea
Keyword(s):  
Drug Targets ◽  
Novel Drug ◽  
Novel Drug Targets
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