scholarly journals X‐Ray Scattering Techniques Applied in the Development of Drug Delivery Systems

10.5772/65326 ◽  
2017 ◽  
Author(s):  
Margareth Kazuyo Kobayashi Dias Franco ◽  
Daniele Ribeiro de Araújo ◽  
Eneida de Paula ◽  
Leide Cavalcanti ◽  
Fabiano Yokaichiya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

Structural Development of Self Nano Emulsifying Drug Delivery Systems (SNEDDS) During In Vitro Lipid Digestion Monitored by Small-angle X-ray Scattering

2007 ◽  
Vol 24 (10) ◽  
pp. 1844-1853 ◽  
Author(s):  
Dimitrios G. Fatouros ◽  
G. Roshan Deen ◽  
Lise Arleth ◽  
Bjorn Bergenstahl ◽  
Flemming Seier Nielsen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Angle ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Structural Development ◽  
Lipid Digestion ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

Water–Tween 40®/Imwitor 308®–isopropyl myristate microemulsions as delivery systems for ketoprofen: Small-angle X-ray scattering study

2006 ◽  
Vol 327 (1-2) ◽  
pp. 170-177 ◽  
Author(s):  
Matija Tomšič ◽  
Filip Podlogar ◽  
Mirjana Gašperlin ◽  
Marija Bešter-Rogač ◽  
Andrej Jamnik
Keyword(s):  
Small Angle ◽  
Delivery Systems ◽  
Isopropyl Myristate ◽  
X Ray ◽  
X Ray Scattering ◽  
Scattering Study ◽  
Tween 40 ◽  
Ray Scattering

scholarly journals Characterization of Phases and Interactions Among Lipids Involved in Drug Delivery: An NMR and Small-Angle X-Ray Scattering Study

2018 ◽  
Vol 114 (3) ◽  
pp. 16a
Author(s):  
Miranda L. Schmidt ◽  
Bashe Y.M. Bashe ◽  
Iulia Bodnariuc ◽  
Joanne E. Mercer ◽  
Sherry S.W. Leung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Angle ◽  
X Ray ◽  
X Ray Scattering ◽  
Scattering Study ◽  
Ray Scattering

Montmorillonite Intercalated Norfloxacin and Tobramycin for New Drug-Delivery Systems

2020 ◽  
Vol 20 (8) ◽  
pp. 5246-5251
Author(s):  
El-Refaie Kenawy ◽  
Nehal O. Shaker ◽  
Mohamed Azaam ◽  
Aya S. Lasheen ◽  
Jianjian Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Fourier Transforms ◽  
Xrd Analysis ◽  
Delivery Systems ◽  
Release Behavior ◽  
X Ray Diffraction ◽  
Release Rates ◽  
X Ray ◽  
Ft Ir

The urgent need of safe, therapeutically and patient-compliant drug delivery systems (DDSs) continuously stimulates researchers to explore novel tools and strategies to monitor the loading and release of drugs. In this context, this study demonstrates that montmorillonite clay (MMT) is an appropriate material for changing the release behavior of Tobramycin and Norfloxacin drugs into medium. The DDSs were prepared by the intercalation of Tobramycin or Norfloxacin between MMT layers. The MMT-drug systems were analyzed using X-ray diffraction (XRD) analysis, scanning electron microscope (SEM), and Fourier transforms infrared (FT-IR). After insertion of the drugs between the layers of MMT, the periodicity in c-axis changed because of the formation of layered hybrid structures. The release of drugs was investigated using UV-spectrophotometer. The release rates are found to be dependent on pH of the medium. Moreover, we found that the percentage of release increases as the pH increases, however the release rate is low. These findings would be beneficial for controlled release of drugs for prolonged time in the future.

scholarly journals Restoring structural parameters of lipid mixtures from small-angle X-ray scattering data

2021 ◽  
Vol 54 (1) ◽  
pp. 169-179 ◽  
Author(s):  
Petr V. Konarev ◽  
Andrey Yu. Gruzinov ◽  
Haydyn D. T. Mertens ◽  
Dmitri I. Svergun
Keyword(s):  
Form Factor ◽  
Small Angle ◽  
Structural Parameters ◽  
Lipid Vesicles ◽  
Delivery Systems ◽  
Scattering Data ◽  
X Ray ◽  
X Ray Scattering ◽  
Lipid Mixtures ◽  
Ray Scattering

Small-angle X-ray scattering (SAXS) is widely utilized to study soluble macromolecules, including those embedded into lipid carriers and delivery systems such as surfactant micelles, phospholipid vesicles and bilayered nanodiscs. To adequately describe the scattering from such systems, one needs to account for both the form factor (overall structure) and long-range-order Bragg reflections emerging from the organization of bilayers, which is a non-trivial task. Presently existing methods separate the analysis of lipid mixtures into distinct procedures using form-factor fitting and the fitting of the Bragg peak regions. This article describes a general approach for the computation and analysis of SAXS data from lipid mixtures over the entire angular range of an experiment. The approach allows one to restore the electron density of a lipid bilayer and simultaneously recover the corresponding size distribution and multilamellar organization of the vesicles. The method is implemented in a computer program, LIPMIX, and its performance is demonstrated on an aqueous solution of layered lipid vesicles undergoing an extrusion process. The approach is expected to be useful for the analysis of various types of lipid-based systems, e.g. for the characterization of interactions between target drug molecules and potential carrier/delivery systems.

scholarly journals Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0242565
Author(s):  
Cristiane Savicki ◽  
Nelson Heriberto Almeida Camargo ◽  
Enori Gemelli
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Calcium Phosphates ◽  
High Vacuum ◽  
Delivery Systems ◽  
Bone Diseases ◽  
Burst Release ◽  
X Ray ◽  
Vacuum Method

Drug delivery systems are a new approach to increase therapeutic efficacy and to reduce the side effects of traditional treatments. Calcium phosphates (CaPs) have been studied as drug delivery systems, especially in bone diseases. However, each system has some particularities that depend on the physical and chemical characteristics of the biomaterials and drug interaction. In this work, granulated CaPs were used as a matrix for loading the anticancer drug carboplatin using the high-vacuum method. Five compositions were applied: hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), biphasic HAp 60%/β-TCP 40% (BCP), β-TCP/MgO nanocomposite, and β-TCP/SiO2 nanocomposite. Carboplatin drug in 50, 60, and 70 mg/g was precipitated on the surface of CaPs. Morphological, chemical and surface modifications in the carboplatin-CaPs were investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), backscattered electron microscopy (BSE), X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), Fourier transform infrared (FT-IR), and Raman spectroscopy. The characterization of the CaP-carboplatin biomaterials showed heterogeneous crystalline precipitation of the drug, and no morphological modifications of the CaPs biomaterials. The in vitro release profile of carboplatin from CaPs was evaluated by the ultraviolet-visible (UV-Vis) method. The curves showed a burst release of upon 60% of carboplatin loaded followed by a slow-release of the drug for the time of the study. The results were typical of a low-interaction system and physisorption mechanism. The high-vacuum method permitted to load the high amount of carboplatin drug on the surface of the biomaterials despite the low interaction between carboplatin and CaPs.

Sign in / Sign up

Export Citation Format

Share Document