scholarly journals Severe and Complicated Malaria due to Plasmodium vivax

10.5772/64974 ◽  
2016 ◽  
Author(s):  
Wilmer E. Villamil-Gómez ◽  
Melisa Eyes-Escalante ◽  
Carlos Franco-Paredes
Keyword(s):  
Plasmodium Vivax ◽  
Complicated Malaria

scholarly journals Comparison of clinical profile between Plasmodium vivax and Plasmodium falciparum malaria in children in tertiary care hospital

2018 ◽  
Vol 5 (4) ◽  
pp. 1294
Author(s):  
Vinod Kumar Ravilala ◽  
Shabbeer Ahmed ◽  
Murali Krishna Vanka ◽  
Rajesh Seepana
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Falciparum Malaria ◽  
Uncomplicated Malaria ◽  
Vivax Malaria ◽  
Tertiary Care ◽  
Plasmodium Falciparum Malaria ◽  
Care Hospital ◽  
Peripheral Smear ◽  
Complicated Malaria

Background: The high prevalence of uncomplicated malaria as seen in this study suggests the importance of timely diagnosis and effective treatment and encourages new activities to further decrease complicated malaria cases.Methods: In this study, malaria was diagnosed by conventional thick and thin peripheral smear stained with Leishman stain, examined under oil immersion. The slide was considered negative when there were no parasites in 100 HPF. Rapid diagnostic tests were based on detection of specific plasmodium antigen, LDH (optimal test) for Vivax and HRP2 for falciparum. The mode of presentations like fever, splenomegaly, vomiting, abdominal pain, laboratory investigations and complications were noted. Simple malaria was defined as Plasmodium vivax or Plasmodium falciparum malaria without any complications. All the statistical analysis was done by using SPSS 16 version and in MS Excel. Qualitative variables were expressed as frequencies and percentages. Chi-square was used for examining the categorical data.Results: A total 100 cases of malaria diagnosed by rapid diagnostic test and/or peripheral smear were studied. 69% of the cases were falciparum malaria and 31% of the cases were vivax malaria. Males were more commonly affected than females. Vivax malaria was most common between 5-10 years of age and falciparum malaria was more common in 0-5 years of age. Uncomplicated malaria was seen in 73% of the cases and complicated malaria was seen in 27% of the cases. Incidence of complicated malaria was more common in case of falciparum malaria. Fever, pallor, hepatomegaly and splenomegaly were significant for clinical diagnosis of malaria.  Severe anaemia was the most common presentation of complicated malaria followed by jaundice. Cerebral malaria was more common in case of falciparum malaria. Metabolic acidosis and renal failure were more common in falciparum malaria. Hypoglycemia, significant bleeding and shock were more common in falciparum malaria. ARDS was most common in vivax malaria.Conclusions: This study emphasizes the importance of severity of P. Vivax malaria and recommends further studies to establish mortality and severity predictors specific to it.

scholarly journals Prevalence of Clinical Artesunate Resistance among Cases of Complicated Malaria in Southern Odisha, India

2020 ◽  
Author(s):  
Sindhusuta Das ◽  
Sanghamitra Padhi
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Falciparum Malaria ◽  
Blood Smear ◽  
Core Body Temperature ◽  
Plasmodium Falciparum Malaria ◽  
Response To Therapy ◽  
Malarial Parasite ◽  
Drug Resistant ◽  
Complicated Malaria

Introduction: Drug resistant malaria represents the most challenging health problem worldwide. The major threat to malaria control is the increasing incidence of complicated and drug-resistant cases. Aim: To determine the prevalence of clinical artesunate resistance among complicated malaria cases by invivo method. Materials and Methods: The study included 241 patients with complicated malaria, which showed trophozoites of malarial parasite Plasmodium in the blood smear. They were administered with artesunate monotherapy. They were then followed-up for clinical response to therapy and quantification of parasitaemia levels on day 1, day 2, day 3, day 7, day 14 and day 28. Clinical examination included core body temperature recording, assessment of associated complications like vomiting, altered sensorium, anaemia, bleeding tendencies and investigation of renal parameters, liver function test and hypoglycaemia. Results: Out of 241 complicated malaria cases showing malarial parasite in peripheral blood smear, 204 cases were of Plasmodium falciparum, 32 cases were of Plasmodium vivaxand five were cases of mixed Plasmodium falciparum and Plasmodium vivax infection. Among the 241 malaria positive cases, the most commonly associated complication was severe anaemia in 87 (36.1%) cases. All the 32 cases of Plasmodium vivax malaria and the five cases of mixed infection responded and recovered after administration of artesunate monotherapy. But among the 204 cases of Plasmodium falciparum, clinical artesunate resistance was detected in 6 (2.94%) cases and the rest 198 (97.06%) cases were sensitive to artesunate monotherapy. Conclusion: Clinical artesunate resistance was noticed in 2.94% cases of Plasmodium falciparum malaria. Hence, continuous monitoring of antimalarial therapy is required, especially in complicated cases of Plasmodium falciparum malaria, to prevent the emergence of artesunate resistance.

scholarly journals Altered platelet indices as potential markers of severe and complicated malaria caused by Plasmodium vivax: a cross-sectional descriptive study

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Fábio A Leal-Santos ◽  
Soraya BR Silva ◽  
Natasha P Crepaldi ◽  
Andréia F Nery ◽  
Thamires OG Martin ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Descriptive Study ◽  
Cross Sectional ◽  
Platelet Indices ◽  
Complicated Malaria

Revealing natural antisense transcripts from Plasmodium vivax isolates: Evidence of genome regulation in complicated malaria

2013 ◽  
Vol 20 ◽  
pp. 428-443 ◽  
Author(s):  
P.A. Boopathi ◽  
Amit Kumar Subudhi ◽  
Shilpi Garg ◽  
Sheetal Middha ◽  
Jyoti Acharya ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Antisense Transcripts ◽  
Natural Antisense Transcripts ◽  
Complicated Malaria ◽  
Genome Regulation
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