scholarly journals Precision Medicine for Sickle Cell Disease: Discovery of Genetic Targets for Drug Development

10.5772/64817 ◽  
2016 ◽  
Author(s):  
Betty S. Pace ◽  
Nicole H. Lopez ◽  
Xingguo Zhu ◽  
Biaoru Li
Keyword(s):  
Sickle Cell Disease ◽  
Drug Development ◽  
Precision Medicine ◽  
Sickle Cell ◽  
Cell Disease

scholarly journals The trials and hopes for drug development in sickle cell disease

2015 ◽  
Vol 170 (6) ◽  
pp. 768-780 ◽  
Author(s):  
Kenneth I. Ataga ◽  
Jonathan Stocker
Keyword(s):  
Sickle Cell Disease ◽  
Drug Development ◽  
Sickle Cell ◽  
Cell Disease

scholarly journals Sickle Cell Disease among Blacks; the Possible Pivotal Role of Precision Medicine: A Focused Review on Management of Pain

2020 ◽  
Vol 27 (2) ◽  
pp. 142-150
Author(s):  
M.A. Ndakotsu ◽  
S.A. Balarabe
Keyword(s):  
Sickle Cell Disease ◽  
Precision Medicine ◽  
Sickle Cell ◽  
Technological Development ◽  
Poor Quality ◽  
Sub Saharan Africa ◽  
Clinical Event ◽  
Cell Disease ◽  
African Region ◽  
Sub Saharan

Sickle Cell Disease (SCD) occurs commonly in sub- Saharan African region. For instance, out of the estimated 305,800 babies born annually with SCD worldwide about 75% occurred in sub-Saharan Africa (SSA). Vasoocclusive painful crisis is the prototype clinical event among SCD patients with nearly all SCD persons experiencing the episode during their lifetime. Additionally, acute vasooculusive pain crises may eventually progressed to chronic pain, resulting in poor quality of life associated with other morbidities, including anxiety, depression and dependence on pain medications. Transformation and technological development that brought about new clinical approaches and treatments have increased rates of survival in patients with Sickle Cell Disease (SCD). However, the overall life expectancy of such patients remains shorter than other normal populations. Therefore, management of pain should be guided by an individualized précised prescribing and monitoring protocol. To this end, the concept of precision medicine that is predicated on using practical application of human genomics provide an evolving set of translational research goals in the management of pain in sickle cell disease. This review tend to shed light on this new concept, hoping that the review will facilitate improved and more accessible care for all patients leaving with sickle cell disease. Keywords: Sickle cell disease, Precision medicine, Pain management, Sickle cell crisis, Hydroxyurea.

scholarly journals Sickle cell disease in the era of precision medicine: looking to the future

2019 ◽  
Vol 4 (6) ◽  
pp. 357-367
Author(s):  
Martin H Steinberg ◽  
Sara Kumar ◽  
George J. Murphy ◽  
Kim Vanuytsel
Keyword(s):  
Sickle Cell Disease ◽  
Precision Medicine ◽  
Sickle Cell ◽  
Cell Disease ◽  
The Future

Hemolysis in sickle cell disease

1974 ◽  
Vol 133 (4) ◽  
pp. 624-631 ◽  
Author(s):  
T. A. Bensinger
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease

Computerized cognitive training in pediatric sickle cell disease: A randomized controlled pilot study.

2020 ◽  
Vol 8 (4) ◽  
pp. 390-401 ◽  
Author(s):  
Taryn M. Allen ◽  
Lindsay M. Anderson ◽  
Samuel M. Brotkin ◽  
Jennifer A. Rothman ◽  
Melanie J. Bonner
Keyword(s):  
Pilot Study ◽  
Sickle Cell Disease ◽  
Cognitive Training ◽  
Sickle Cell ◽  
Cell Disease ◽  
Computerized Cognitive Training ◽  
Randomized Controlled ◽  
Pediatric Sickle Cell Disease
Sign in / Sign up

Export Citation Format

Share Document