scholarly journals Vitamin D and Female Reproduction

10.5772/64502 ◽  
2017 ◽  
Author(s):  
Heba Elhusseini ◽  
Daria Lizneva ◽  
Larisa Gavrilova-Jordan ◽  
Noura Eziba ◽  
Mohamed Abdelaziz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Female Reproduction

Role of vitamin D in female Reproduction

2016 ◽  
Vol 455 ◽  
pp. 33-38 ◽  
Author(s):  
Seyedeh Zahra Shahrokhi ◽  
Firouzeh Ghaffari ◽  
Faranak Kazerouni
Keyword(s):  
Vitamin D ◽  
Female Reproduction

scholarly journals The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1567
Author(s):  
Irene Moridi ◽  
Alice Chen ◽  
Oded Tal ◽  
Reshef Tal
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Ovarian Reserve ◽  
Potential Benefit ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Human Reproduction ◽  
Female Reproduction ◽  
The Relationship

Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

scholarly journals A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elham Karimi ◽  
Arman Arab ◽  
Masoumeh Rafiee ◽  
Reza Amani
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Ovarian Reserve ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Normal Body Mass Index ◽  
Adult Women ◽  
Female Reproduction ◽  
Serum Vitamin D ◽  
Vitamin D Levels

AbstractIt is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD − 0.65; 95% CI − 1.28 to − 0.01; P = 0.04; I2 = 0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P = 0.031; I2 = 9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher’s Z: − 0.18; 95% CI − 0.37 to − 0.008; P = 0.041; I2 = 51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.

scholarly journals Vitamin D and women’s reproductive health (literature review)

2018 ◽  
pp. 164-172 ◽  
Author(s):  
Ya. Z. Zaydieva ◽  
V. E. Balan
Keyword(s):  
Vitamin D ◽  
Reproductive Health ◽  
Literature Review ◽  
Polycystic Ovary ◽  
Review Literature ◽  
Female Reproduction ◽  
Metabolic Disturbances ◽  
Health Literature ◽  
Women’S Reproductive Health ◽  
Women's Reproductive Health

Vitamin D and women’s reproductive health (literature review). Literature search the relationship between vitamin D and fertility in women рerformed in Pubmed. The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis. 

Current Understanding of the Molecular Actions of Vitamin D

1998 ◽  
Vol 78 (4) ◽  
pp. 1193-1231 ◽  
Author(s):  
GLENVILLE JONES ◽  
STEPHEN A. STRUGNELL ◽  
HECTOR F. DeLUCA
Keyword(s):  
Vitamin D ◽  
Parathyroid Gland ◽  
Active Form ◽  
Current Understanding ◽  
Target Cells ◽  
Female Reproduction ◽  
Physiological Level ◽  
Dihydroxyvitamin D ◽  
Hydroxylation Reaction

Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193–1231, 1998. — The important reactions that occur to the vitamin D molecule and the important reactions involved in the expression of the final active form of vitamin D are reviewed in a critical manner. After an overview of the metabolism of vitamin D to its active form and to its metabolic degradation products, the molecular understanding of the 1α-hydroxylation reaction and the 24-hydroxylation reaction of the vitamin D hormone is presented. Furthermore, the role of vitamin D in maintenance of serum calcium is reviewed at the physiological level and at the molecular level whenever possible. Of particular importance is the regulation of the parathyroid gland by the vitamin D hormone. A third section describes the known molecular events involved in the action of 1α,25-dihydroxyvitamin D3 on its target cells. This includes reviewing what is now known concerning the overall mechanism of transcriptional regulation by vitamin D. It describes the vitamin D receptors that have been cloned and identified and describes the coactivators and retinoid X receptors required for the function of vitamin D in its genomic actions. The presence of receptor in previously uncharted target organs of vitamin D action has led to a study of the possible function of vitamin D in these organs. A good example of a new function described for 1α,25-dihydroxyvitamin D3 is that found in the parathyroid gland. This is also true for the role of vitamin D hormone in skin, the immune system, a possible role in the pancreas, i.e., in the islet cells, and a possible role in female reproduction. This review also raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout. The final section reviews some interesting analogs of the vitamin D hormone and their possible uses. The review ends with possible ideas with regard to future directions of vitamin D drug design.

Association of vitamin D receptor genotypes with early onset rheumatoid arthritis

2001 ◽  
Vol 28 (1) ◽  
pp. 89-93 ◽  
Author(s):  
J. R. Garcia-Lozano ◽  
M. F. Gonzalez-Escribano ◽  
A. Valenzuela ◽  
A. Garcia ◽  
A. Nunez-Roldan
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Early Onset

803: Interactions Between Ultraviolet Radiation and Polymorphisms in the Vitamin D Receptor Gene Mediate Prostate Cancer Susceptibility

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Nicholas J. Rukin ◽  
Samuel J. Moon ◽  
Dhaval Bodiwala ◽  
Christopher J. Luscombe ◽  
Mark F. Saxby ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Ultraviolet Radiation ◽  
Vitamin D Receptor ◽  
Cancer Susceptibility ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Prostate Cancer Susceptibility
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