scholarly journals Antibody Responses after Influenza Vaccination in Elderly People: Useful Information from a 27-Year Study (from 1988– 1989 to 2014–2015)

10.5772/64405 ◽  
2016 ◽  
Author(s):  
Barbara Camilloni ◽  
Emilia Nunzi ◽  
Michela Basileo ◽  
Anna Maria Iorio
Keyword(s):  
Influenza Vaccination ◽  
Elderly People ◽  
Antibody Responses

scholarly journals Antibody-dependent cell-mediated cytotoxicity antibody responses to inactivated and live-attenuated influenza vaccination in children during 2014–15

Vaccine ◽  
2020 ◽  
Vol 38 (8) ◽  
pp. 2088-2094
Author(s):  
Kelsey Florek ◽  
James Mutschler ◽  
Huong Q. McLean ◽  
Jennifer P. King ◽  
Brendan Flannery ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Antibody Responses ◽  
Dependent Cell

Mortality benefits of influenza vaccination in elderly people

2008 ◽  
Vol 8 (8) ◽  
pp. 460-461 ◽  
Author(s):  
Carel Thijs ◽  
Walter EP Beyer ◽  
Phile ME Govaert ◽  
Marc JW Sprenger ◽  
Geert-Jan Dinant ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Elderly People

scholarly journals Influenza Vaccination in Elderly People Who Has it and Why?

1998 ◽  
Vol 27 (suppl 1) ◽  
pp. P38-P39
Author(s):  
M.A. Gosney ◽  
V. Clark
Keyword(s):  
Influenza Vaccination ◽  
Elderly People

The Effect of Influenza Vaccination History on Changes in Hemagglutination Inhibition Titers After Receipt of the 2015–2016 Influenza Vaccine in Older Adults in Hong Kong

2019 ◽  
Vol 221 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Tiffany W Y Ng ◽  
Ranawaka A P M Perera ◽  
Vicky J Fang ◽  
Emily M Yau ◽  
J S Malik Peiris ◽  
...  
Keyword(s):  
Older Adults ◽  
Hong Kong ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Hemagglutination Inhibition ◽  
Age Groups ◽  
Antibody Responses ◽  
Serum Samples ◽  
Vaccination History ◽  
Antibody Titers

Abstract Background Immune responses to influenza vaccination can be weaker in older adults than in other age groups. We hypothesized that antibody responses would be particularly weak among repeat vaccinees when the current and prior season vaccine components are the same. Methods An observational study was conducted among 827 older adults (aged ≥75 years) in Hong Kong. Serum samples were collected immediately before and 1 month after receipt of the 2015–2016 quadrivalent inactivated influenza vaccine. We measured antibody titers with the hemagglutination inhibition assay and compared the mean fold rise from prevaccination to postvaccination titers and the proportions with postvaccination titers ≥40 or ≥160. Results Participants who reported receipt of vaccination during either of the previous 2 years had a lower mean fold rise against all strains than with those who did not. Mean fold rises for A(H3N2) and B/Yamagata were particularly weak after repeated vaccination with the same vaccine strain, but we did not generally find significant differences in the proportions of participants with postvaccination titers ≥40 and ≥160. Conclusions Overall, we found that reduced antibody responses in repeat vaccinees were particularly reduced among older adults who had received vaccination against the same strains in preceding years.

scholarly journals Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination

2020 ◽  
Vol 7 (5) ◽  
Author(s):  
Nathalie Loeb ◽  
Melissa K Andrew ◽  
Mark Loeb ◽  
George A Kuchel ◽  
Laura Haynes ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Hemagglutination Inhibition ◽  
Influenza A ◽  
Standard Dose ◽  
Geometric Mean ◽  
Frailty Index ◽  
Antibody Responses ◽  
High Dose ◽  
Antibody Titers ◽  
The Impact

Abstract Background Although high-dose (HD) vaccines have been reported to stimulate higher antibody responses compared with standard-dose (SD) influenza vaccines, there have been limited studies on the impact of frailty on such responses. Methods We conducted a randomized, double-blind trial (2014/2015 to 2017/2018) of SD versus HD trivalent split-virus vaccine (Fluzone) in 612 study participants aged 65+ over 4 influenza seasons. Hemagglutination inhibition antibody titers for influenza H1N1, H3N2, and B vaccine subtypes were measured at baseline and at 4, 10, and 20 weeks postvaccination and frailty was measured using a validated frailty index. Results Geometric mean antibody titers were significantly higher in HD compared with SD vaccine recipients for all influenza subtypes at all time points postvaccination. However, frailty was positively correlated with 4-week titers and was associated with increased odds of being a vaccine responder. For influenza A subtypes, this was mostly limited to HD recipients. Conclusions Frailty was associated with higher titers and increased antibody responses at 4 weeks after influenza vaccination, which was partially dependent on vaccine dosage. Chronic inflammation or dysregulated immunity, both of which are commonly observed with frailty, may be responsible, but it requires further investigation.

scholarly journals Impact of Mixed Equine Influenza Vaccination on Correlate of Protection in Horses

Vaccines ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 71 ◽  
Author(s):  
Mohamed Dilai ◽  
Mohammed Piro ◽  
Mehdi El Harrak ◽  
Stéphanie Fougerolle ◽  
Mohammed Dehhaoui ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Poor Response ◽  
Primary Vaccination ◽  
Vaccination Schedule ◽  
Antibody Responses ◽  
Equine Influenza ◽  
Correlate Of Protection ◽  
Humoral Immune ◽  
Clinical Protection ◽  
One Year

To evaluate the humoral immune response to mixed Equine Influenza vaccination, a common practice in the field, an experimental study was carried out on 42 unvaccinated thoroughbred weanling foals divided into six groups of seven. Three groups were vaccinated using a non-mixed protocol (Equilis® Prequenza-Te, Proteqflu-Te® or Calvenza-03®) and three other groups were vaccinated using a mix of the three vaccines mentioned previously. Each weanling underwent a primary EI vaccination schedule composed of two primary immunisations (V1 and V2) four weeks apart followed by a third boost immunisation (V3) six months later. Antibody responses were monitored until one-year post-V3 by single radial haemolysis (SRH). The results showed similar antibody responses for all groups using mixed EI vaccination and the group exclusively vaccinated with Equilis® Prequenza-TE, which were significantly higher than the other two groups vaccinated with Proteqflu-TE® and Calvenza-03®. All weanlings (100%) failed to seroconvert after V1 and 21% (9/42) still had low or no SRH antibody titres two weeks post-V2. All weanlings had seroconverted and exceeded the clinical protection threshold one month after V3. The poor response to vaccination was primarily observed in groups exclusively vaccinated with Proteqflu-Te® and Calvenza-03®. A large window of susceptibility (3–4.5-month duration) usually called immunity gap was observed after V2 and prior to V3 for all groups. The SRH antibody level was maintained above the clinical protection threshold for three months post-V3 for the groups exclusively vaccinated with Proteqflu-Te® and Calvenza-03®, and six months to one year for groups using mixed EI vaccination or exclusively vaccinated with Equilis® Prequenza-Te. This study demonstrates for the first time that the mix of EI vaccines during the primary vaccination schedule has no detrimental impact on the correlate of protection against EIV infection.

Negative effect on immune response of repeated influenza vaccination and waning effectiveness in interseason for elderly people

Vaccine ◽  
2020 ◽  
Vol 38 (21) ◽  
pp. 3759-3765
Author(s):  
Yoshiyuki Sugishita ◽  
Tetsuo Nakayama ◽  
Tamie Sugawara ◽  
Yasushi Ohkusa
Keyword(s):  
Immune Response ◽  
Influenza Vaccination ◽  
Elderly People ◽  
Negative Effect

Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population

Vaccine ◽  
2001 ◽  
Vol 19 (32) ◽  
pp. 4610-4617 ◽  
Author(s):  
Elizabeth M. Gardner ◽  
Erica D. Bernstein ◽  
Sandra Dran ◽  
Gary Munk ◽  
Peter Gross ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Elderly Population ◽  
Antibody Responses ◽  
Healthy Elderly

scholarly journals Non‐neutralizing antibody responses following A(H1N1)pdm09 influenza vaccination with or without AS03 adjuvant system

2020 ◽  
Vol 15 (1) ◽  
pp. 110-120
Author(s):  
Damien Friel ◽  
Mary Co ◽  
Thierry Ollinger ◽  
Bruno Salaun ◽  
Anne Schuind ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Adjuvant System

scholarly journals Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A

Blood ◽  
2016 ◽  
Vol 127 (26) ◽  
pp. 3439-3449 ◽  
Author(s):  
Jesse D. Lai ◽  
Paul C. Moorehead ◽  
Kate Sponagle ◽  
Katharina N. Steinitz ◽  
Birgit M. Reipert ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza Vaccination ◽  
Hemophilia A ◽  
Antibody Responses ◽  
Inhibitor Development ◽  
Key Points ◽  
Antigenic Competition ◽  
Cell Chemotaxis

Key Points Vaccination against influenza, with and without the adjuvant MF59, decreases the risk of inhibitor development in HA mice. Decreased FVIII immunogenicity may be attributed to antigenic competition via T-cell chemotaxis toward the site of vaccination.

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