scholarly journals Maternal Influenza: Infection, Vaccination, and Compelling Questions

10.5772/64368 ◽  
2016 ◽  
Author(s):  
Jill M. Manske
Keyword(s):  
Influenza Infection ◽  
Maternal Influenza

scholarly journals Paradoxical long-term impact of maternal influenza infection on neonates and infants

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Joon Young Song ◽  
Keon Vin Park ◽  
Sung Won Han ◽  
Min Joo Choi ◽  
Ji Yun Noh ◽  
...  
Keyword(s):  
Influenza Infection ◽  
Long Term Impact ◽  
Neonates And Infants ◽  
Maternal Influenza

Prenatal teratogens and the development of adult mental illness

1999 ◽  
Vol 11 (3) ◽  
pp. 457-466 ◽  
Author(s):  
JENNIFER B. WATSON ◽  
SARNOFF A. MEDNICK ◽  
MATTI HUTTUNEN ◽  
XUEYI WANG
Keyword(s):  
Mental Illness ◽  
Affective Disorder ◽  
Maternal Stress ◽  
Influenza Infection ◽  
Fetal Brain ◽  
Unipolar Depression ◽  
Richter Scale ◽  
Increase Risk ◽  
Increasing Risk ◽  
Maternal Influenza

Our findings in the Helsinki Influenza Study and the Danish Forty Year Study lead us to conclude that a 2nd-trimester maternal influenza infection may increase risk for adult schizophrenia or adult major affective disorder. More recently we have also reported an increase of unipolar depression among offspring who were exposed prenatally to a severe earthquake (7.8 on the Richter scale) in Tangshan, China. Among the earthquake-exposed males (but not the females), we observed a significantly greater depression response for those individuals exposed during the 2nd trimester of gestation. These findings suggest that maternal influenza infection and severe maternal stress may operate (in different ways) as teratogens, disrupting the development of the fetal brain and increasing risk for developing schizophrenia or depression in adulthood.

scholarly journals Assessment of Effectiveness of Seasonal Influenza Vaccination During Pregnancy in Preventing Influenza Infection in Infants in England, 2013–2014 and 2014–2015

2019 ◽  
Author(s):  
Jemma L Walker ◽  
Hongxin Zhao ◽  
Gavin Dabrera ◽  
Nick Andrews ◽  
Sarah L Thomas ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Confidence Interval ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Influenza Infection ◽  
Screening Method ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Uptake Data ◽  
Maternal Influenza

AbstractMaternal influenza vaccination is increasingly recognized to protect infants from influenza infection in their first 6 months. We used the screening method to estimate vaccine effectiveness (VE) against laboratory-confirmed influenza in infants in England, using newly available uptake data from the Clinical Practice Research Datalink pregnancy register, matched on week of birth and region and adjusted for ethnicity. We found VE of 66% (95% confidence interval [CI], 18%–84%) in the 2013–2014 season and 50% (95% CI, 11%–72%) in 2014–2015, with similar VE against influenza-related hospitalization. VE against the dominant circulating influenza strain was higher, at 78% (95% CI, 16%–94%) against H1N1 in 2013–2014, and 60% (95% CI, 16%–81%) against H3N2 in 2014–2015.

Influenza as a Measure of Maternal Immune Activation and Its Effects on the Incidence of Encephalocele and Microtia

FACE ◽  
2020 ◽  
pp. 273250162097302
Author(s):  
Arsh Momin ◽  
Dayton Grogan ◽  
William Carroll ◽  
Daniel Linder ◽  
Jack C. Yu
Keyword(s):  
Strong Correlation ◽  
Influenza Infection ◽  
Enteric Virus ◽  
The United States ◽  
Mixed Effect ◽  
Maternal Immune Activation ◽  
Virus Surveillance ◽  
National Estimates ◽  
Maternal Immune Response ◽  
Maternal Influenza

Objective: Activation of the maternal immune (MIA) system while pregnant can have significant effects on fetal development. Here, the authors sought to examine MIA and its effects on fetal craniofacial formation. As a measure of MIA, data on maternal influenza infection was used, as influenza occurs in a predictive fashion, is not vertically transmitted, and is found to generate a robust maternal immune response. Thus, this study measures the association of the incidence of influenza infection in the United States with the incidence of craniofacial congenital deficits—specifically encephalocele and microtia. Methods: The National Inpatient Sample Database (NIS) was referenced to identify national estimates of infants born with each disease from 2004 to 2013. The gross monthly disease incidences were adjusted based on the number of newborns each month. The National Respiratory and Enteric Virus Surveillance System’s FluView database from the CDC was used to obtain influenza data from 2003 to 2013. Mixed effect logistic regression analyses were conducted to find the association between influenza occurrence and each disease, specifically an odds ratio (OR). Results: There were 2858 infants born with encephalocele and 3371 born with microtia from January 2004 to December 2013. Microtia showed no statistically significant correlation with influenza rates and served as a methodologic control. Encephalocele, however, showed a strong correlation with influenza infection specifically during the eighth month of pregnancy (OR = 34.538, 95% confidence interval: 3.815-312.681). Conclusion: This study shows a strong correlation between maternal influenza infection during the eighth month of pregnancy and encephalocele incidence. This suggests that there is an additional trigger for encephalocele development towards the end of the pregnancy not currently understood in the literature. Although there appears to be a connection between MIA and encephalocele formation, more research is needed to confirm this theory.

scholarly journals Maternal Influenza Infection During Pregnancy Impacts Postnatal Brain Development in the Rhesus Monkey

2010 ◽  
Vol 67 (10) ◽  
pp. 965-973 ◽  
Author(s):  
Sarah J. Short ◽  
Gabriele R. Lubach ◽  
Alexander I. Karasin ◽  
Christopher W. Olsen ◽  
Martin Styner ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Brain Development ◽  
Influenza Infection ◽  
Postnatal Brain ◽  
Maternal Influenza

scholarly journals Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial

2019 ◽  
Vol 220 (6) ◽  
pp. 956-960
Author(s):  
Alastair F Murray ◽  
Janet A Englund ◽  
Jane Kuypers ◽  
James M Tielsch ◽  
Joanne Katz ◽  
...  
Keyword(s):  
Influenza Infection ◽  
Respiratory Illness ◽  
Community Based ◽  
Influenza Immunization ◽  
Pneumococcal Carriage ◽  
Lower Respiratory Tract Disease ◽  
Syncytial Virus ◽  
Tract Disease ◽  
Post Hoc ◽  
Maternal Influenza

Abstract In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.

scholarly journals Childhood seizures after prenatal exposure to maternal influenza infection: a population-based cohort study from Norway, Australia and Canada

2021 ◽  
pp. archdischild-2021-322210
Author(s):  
Laura L Oakley ◽  
Annette K Regan ◽  
Deshayne B Fell ◽  
Sarah Spruin ◽  
Inger Johanne Bakken ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Fixed Effects ◽  
Cox Regression ◽  
Influenza Infection ◽  
International Study ◽  
Febrile Seizures ◽  
First Trimester ◽  
Population Based ◽  
Increased Risk ◽  
Maternal Influenza

ObjectiveTo assess whether clinical and/or laboratory-confirmed diagnosis of maternal influenza during pregnancy increases the risk of seizures in early childhood.DesignAnalysis of prospectively collected registry data for children born between 2009 and 2013 in three high-income countries. We used Cox regression to estimate country-level adjusted HRs (aHRs); fixed-effects meta-analyses were used to pool adjusted estimates.SettingPopulation-based.Participants1 360 629 children born between 1 January 2009 and 31 December 2013 in Norway, Australia (New South Wales) and Canada (Ontario).ExposureClinical and/or laboratory-confirmed diagnosis of maternal influenza infection during pregnancy.Main outcome measuresWe extracted data on recorded seizure diagnosis in secondary/specialist healthcare between birth and up to 7 years of age; additional analyses were performed for the specific seizure outcomes ‘epilepsy’ and ‘febrile seizures’.ResultsAmong 1 360 629 children in the study population, 14 280 (1.0%) were exposed to maternal influenza in utero. Exposed children were at increased risk of seizures (aHR 1.17, 95% CI 1.07 to 1.28), and also febrile seizures (aHR 1.20, 95% CI 1.07 to 1.34). There was no strong evidence of an increased risk of epilepsy (aHR 1.07, 95% CI 0.81 to 1.41). Risk estimates for seizures were higher after influenza infection during the second and third trimester than for first trimester.ConclusionsIn this large international study, prenatal exposure to influenza infection was associated with increased risk of childhood seizures.

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