scholarly journals Maspin Expression and its Metastasis Suppressing Function in Prostate Cancer

10.5772/64336 ◽  
2016 ◽  
Author(s):  
Eswar Shankar ◽  
Mario Candamo ◽  
Gregory T. MacLennan ◽  
Sanjay Gupta
Keyword(s):  
Prostate Cancer ◽  
Maspin Expression

scholarly journals Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer

2020 ◽  
Vol 59 (8) ◽  
pp. 955-966
Author(s):  
Eswar Shankar ◽  
Mitali Pandey ◽  
Shiv Verma ◽  
Ata Abbas ◽  
Mario Candamo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Histone Deacetylases ◽  
Class I ◽  
Maspin Expression

scholarly journals The induction of Maspin expression by a glucosamine-derivative has an antiproliferative activity in prostate cancer cell lines

2019 ◽  
Vol 300 ◽  
pp. 63-72 ◽  
Author(s):  
Rossana Cocchiola ◽  
Mariangela Lopreiato ◽  
Raffaella Guazzo ◽  
Maria Margherita de Santi ◽  
Margherita Eufemi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Maspin Expression

scholarly journals Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis

2003 ◽  
Vol 100 (13) ◽  
pp. 7847-7852 ◽  
Author(s):  
M. L. Cher ◽  
H. R. Biliran ◽  
S. Bhagat ◽  
Y. Meng ◽  
M. Che ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Tumor Growth ◽  
Maspin Expression

scholarly journals Gum mastic increases maspin expression in prostate cancer cells

2007 ◽  
Vol 28 (4) ◽  
pp. 567-572 ◽  
Author(s):  
Mei-lan HE ◽  
Wei-wen CHEN ◽  
Peng-ju ZHANG ◽  
An-li JIANG ◽  
Wei FAN ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Maspin Expression

238: Adeno-Associated Virus 2-Mediated Intratumoral Prostate Cancer Gene Therapy: Long-Term Maspin Expression Efficiently Suppresses Tumor Growth

2005 ◽  
Vol 173 (4S) ◽  
pp. 65-65
Author(s):  
Masami Watanabe ◽  
Yasutomo Nasu ◽  
Norihiro Kusumi ◽  
Atsushi Nagai ◽  
Hiromi Kumon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Tumor Growth ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Adeno Associated Virus ◽  
Maspin Expression

Adeno-Associated Virus 2-Mediated Intratumoral Prostate Cancer Gene Therapy: Long-Term Maspin Expression Efficiently Suppresses Tumor Growth

2005 ◽  
Vol 16 (6) ◽  
pp. 699-710 ◽  
Author(s):  
Masami Watanabe ◽  
Yasutomo Nasu ◽  
Yuji Kashiwakura ◽  
Norihiro Kusumi ◽  
Kenji Tamayose ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Tumor Growth ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Adeno Associated Virus ◽  
Maspin Expression

scholarly journals Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells

2010 ◽  
Vol 17 (1) ◽  
pp. 241-253 ◽  
Author(s):  
Frédéric R Santer ◽  
Kamilla Malinowska ◽  
Zoran Culig ◽  
Ilaria T Cavarretta
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Interleukin 6 ◽  
Thymidine Incorporation ◽  
Proliferative Effect ◽  
Prostate Cells ◽  
Selective Targeting ◽  
Maspin Expression ◽  
And Migration ◽  
Different Content

Interleukin-6 (IL-6) is suggested to have a pathogenic role in the progression of prostate cancer (PC), therefore representing an attractive target for new therapies. However, due to the pleiotropy of this cytokine, targeting IL-6 results in different and unpredictable responses. In order to better understand the mechanisms underlying the different responses to the cytokine, we focused our attention on IL-6 receptors (IL-6Rs) that represent the first element in the cascade of cytokine-activated signalling pathways. IL-6 signal transduction may indeed occur through the membrane IL-6R (classical signalling) and/or through the less studied soluble IL-6R (sIL-6R; IL-6 trans-signalling (IL-6TS)). We provide the first evidence how responses to IL-6 may depend on the different content of IL-6Rs in PC. In particular, the studies of 3H-thymidine incorporation and exploitation of different approaches (i.e. activation or inhibition of IL-6TS in sIL-6R-negative and -positive cell lines and transfection of IL-6R siRNA) allowed us to demonstrate that IL-6TS specifically accounts for an anti-proliferative effect of the cytokine in three PC cell lines that are known to respond differently to IL-6. Additionally, by applying migration-, scratch- and adhesion assays, we show that IL-6TS increases motility and migration and decreases adhesion of prostate cells facilitating thereby processes that determine metastasis initiation and spread. Finally, by western analyses, we uncovered an IL-6- and sIL-6R-dependent downregulation of the tumour suppressor maspin. Collectively, these data suggest that selective targeting of IL-6TS might allow to refine the currently available experimental anti-IL-6 therapies against PC.

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